Quaranta A, Scaringi A, Sallustio V, Quaranta N. Cochlear function in ears with immunomediated inner ear disorder. Acta Otolaryngo l 2002; Suppl 548: 15 -19.The aim of the presen t study was to evaluat e the performance of ears with inner ear disorder , responsive to immunosupp ressive drugs, in advanced tests designed to assess primary cochlea r functions (temporal integration, frequency selectivity, cochlear mechanics). The results of this study suggest that immunomedia ted inner ear disease results, in the acute clinical stage, in the developmen t of endolymphat ic hydrops, which increases the stiffness of the vibrating structures within the inner ear and causes dysfunction s of the outer hair cells. Our patients presented with upsloping or at sensorineura l hearing loss, absence of evoked otoacoustic emissions and distortion-product otoacoustic evoked emissions and abnorma l temporal integration, frequency selectivity and cochlea r mechanics. F ollowing immunosupp ressive treatment, hydrop s recovered , hearing subsequently returned to normal, the audiometr ic curve became at at low-to-middle frequencies and primary cochlea r function tended to normalize. This study seems to suppor t the usefulness of testing primary cochlea r function s in order to monitor the clinical course of immunomediated inner ear disorders.