Clinical Experience With N-Butyl Cyanoacrylate Tissue Adhesive in Corneal Perforations Secondary to Herpetic Keratitis

Moorthy, Sonia; Jhanji, Vishal; Constantinou, Marios; Beltz, Jacqueline; Graue-Hernández, Enrique O; Vajpayee, Rasik B

doi:10.1097/ico.0b013e3181cbfa13

Cited by 34 publications

(21 citation statements)

References 13 publications

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“…[1][2][3][4][14][15][16][17][18][19] Failure to diagnose and treat a perforation early can lead to further corneal damage, cataract formation, secondary glaucoma due to formation of peripheral anterior synechiae, and loss of the eye, especially if the inflammatory response is marked. 15 Further, a delay in the management could result in amblyopia of the affected eye, especially when the central cornea is involved.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 In one such series of 46 eyes of 46 patients, only 2 were children and both had therapeutic PKP; 1 child had a failed PKP but was 6 months old and another child (5 years old) had successful PKP after initial glue for perforation due to HSK. 18 In one of the largest pediatric specific series of microbial keratitis, only 2 patients out of 78 presented with perforation.…”

Section: Discussionmentioning

confidence: 99%

“…Although the literature has reports about management of bacterial and fungal keratitis in mixed cohorts of adults and children, 2,[14][15][16][17][18] especially in developing countries, there is little about the management of protozoal or viral keratitis and even less about non-infectious keratitis leading to perforation in children.…”

Section: Introductionmentioning

confidence: 99%

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Management of inflammatory corneal melt leading to central perforation in children: a retrospective study and review of literature

Medsinge

Gajdošová

Moore

et al. 2016

Eye

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Purpose To assess the outcome of early therapeutic penetrating keratoplasty (PKP) for corneal melt leading to perforation in children.Methods Case notes of all the consecutive patients presenting with acute corneal perforation that underwent urgent therapeutic PKP between 2000 and 2010 to the practice of one of the authors, both NHS at Great Ormond Street Hospital for Children and private, were retrospectively reviewed. Onset of perforation, underlying cause, medical and surgical treatment, pre-and post-operative visual acuity, graft clarity, length of followup, and post-operative complications were recorded. Results Four eyes of four consecutive patients (mean age of 9.5 years and median 8.5 years, range 4-17 years) were treated for acquired acute onset corneal perforations. There were three females and one male.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Management of inflammatory corneal melt leading to central perforation in children: a retrospective study and review of literature

Medsinge

Gajdošová

Moore

et al. 2016

Eye

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“…A little over one third of their patients healed with glue application alone and slightly more than half went on to have a subsequent therapeutic keratoplasty. (16) Furthermore, Garg et al were able to show that cyanoacrylate can also be useful when treating fungal keratitis (17). 42 of 66 eyes treated with glue led to resolution of keratomycosis with subsequent scar formation.…”

Section: Corneal Gluingmentioning

confidence: 99%

Surgical management of corneal infections

Tuli

Gray

2016

Current Opinion in Ophthalmology

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Purpose of review The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of corneal infections. While the mainstay of treatment of corneal infections is topical antimicrobial agents, surgical intervention may be necessary in a number of cases. These include advanced disease at presentation, resistant infections, and progressive ulceration despite appropriate treatment. Prompt and appropriate treatment can make the difference between a good outcome and loss of vision or the eye. Recent findings There are a number of surgical therapies available for corneal infections. Preferred therapeutic modalities differ based on the size, causation, and location of the infection but consist of either replacement of the infected tissue or structural support of the tissue to allow healing. While there are no completely novel therapies that have been developed recently, there have been incremental improvements in the existing treatment modalities making them more effective, easier, and safer. Summary Several options are available for surgically managing corneal infections. Ophthalmologists should select the optimal procedure based on the individual patient’s situation.

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“…Although the tissue adhesives cyanoacrylate and fibrin glue are widely used in smaller corneal perforations, they cannot be sustained in the defect site as a filling material [6]. The success rate decreases to 37% with cyanoacrylate application alone in corneal perforations associated with herpetic keratitis [7]. …”

Section: Introductionmentioning

confidence: 99%

Simplified Technique for Sealing Corneal Perforations Using a Fibrin Glue-Assisted Amniotic Membrane Transplant-Plug

Kara

Arıkan

Erşan

et al. 2014

Case Reports in Ophthalmological Medicine

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Purpose. To describe a surgical technique using amniotic membrane transplant (AMT) with fibrin glue (FG) for treating smaller corneal perforations more practically and appropriately filling the defect. Method. A patient with noninfectious central corneal perforation, in 1 mm in diameter, was treated with FG-assisted AMT-plug. An AMT was folded in on itself twice by using FG then a small piece of this FG-AMT mixture was cut to maintain an appropriate plug for the site of the corneal perforation. The FG-assisted AMT-plug was placed in the perforation area by using FG. An amniotic membrane patch was placed over the plug, which was then secured by a bandage contact lens. Result. Surgery to restore corneal stromal thickness without recurrence of perforation. Conclusion. The FG-assisted AMT-plug allowed a successful repair of 1 mm in diameter corneal perforation. This technique was easily performed, thus seeming to be a good alternative to treat corneal perforations with restoring corneal thickness.

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Clinical Experience With N-Butyl Cyanoacrylate Tissue Adhesive in Corneal Perforations Secondary to Herpetic Keratitis

Abstract: Corneal perforations associated with herpetic keratitis may not heal with glue application alone, and corneal transplantation surgery may be required to maintain the ocular structural integrity.

Cited by 34 publications

References 13 publications

Management of inflammatory corneal melt leading to central perforation in children: a retrospective study and review of literature

Management of inflammatory corneal melt leading to central perforation in children: a retrospective study and review of literature

Surgical management of corneal infections

Simplified Technique for Sealing Corneal Perforations Using a Fibrin Glue-Assisted Amniotic Membrane Transplant-Plug

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