Clinical experience with induction chemotherapy with TPP (THP-ADM, CDDP, PEP), TPF (THP-ADM, CDDP, 5-FU) and docetaxel for oral squamous cell carcinomas.

Abstract

We designed chemotherapeutic regimens combining docetaxel (TXT) and TPP (THP-ADM, CDDP, PEP) or TXT and TPF (THP-ADM, CDDP, 5 FU) for the treatment of oral squamous cell carcinomas and evaluated their primary effects. Nine patients were treated. Forty milligrams of TXT per square meter was administered on day 2 intravenously. The patients were 6 men and 2 women 43 to 55 years of age (mean age, 50) years at presentation. The primary site was the tongue in 6 patients and the mandibular gingiva in 2. TNM classification was T 2 in 4 patients, T 3 in 2, T 4 in 2, and N 2 b in 2. All cases were M 0.The response rate with a combination of TXT and TPP was 100% (CR 50%, PR 50%) and that with a combination of TXT and TPF was also 100% (CR 50%, PR 50% ) . Among the 5 patients who additionally received surgery, the Ohboshi & Shimozato classification was II B in 3 and N B in 2.The main side effects were febrile neutropenia, anorexia, and stomatitis, but there was no effect on subsequent treatment.We conclude that our chemotherapeutic regimens are effective against oral squamous cell carcinoma.