Clinical Experience with Frame Based Stereotactic Biopsy for Intracranial Space Occupying Lesion

Abstract

Introduction: Preoperative diagnosis of intracranial space occupying lesion based solely on clinical and neuroimaging evaluation may not be sufficient to institute treatment plan without histopathological certainty. Frame based stereotactic biopsy is a technique of retrieving biopsy specimen to determine the histopathology. The aim of this study is to assess the efficacy and accuracy of frame based technique.Methods: This is a cross-sectional study conducted among 80 patients who underwent computed tomography guided frame based stereotactic biopsy during a period of 6 years. All operations were performed under local anesthesia. Histopathology reports were retrieved and accuracy of biopsy technique analyzed. Results:Out of 80 patients, 58 were male with male to female ratio of 2.6:1. Median age of patients were 50 years with range from 16 to 75 years. Most lesions were in deeper location 49 (61.3%). Most common location was Parietal, 15 (18.8%) followed by Thalamic, 12 (15%). Mean size of lesion was 2.88±0.71cms ranged from 2 to 5cms. Biopsy was accurate to retrieve target in 74 (92.5%) patients. Histopathology revealed glial tumor in 41 (51.2%) of cases. Overall morbidity was observed in 3 (5.5%) patients. There is no procedure related mortality in this study during study period. Conclusions:Frame based biopsy of intracranial space occupying lesion is safe and efficacious procedure with high diagnostic yield.

Indicators of correct targeting in stereotactic biopsy of intracranial lesions

“…[2,12,16,21,22,23,27,34,52,51,53] is result may be related to the relatively great number of samples (n = 12) collected during the procedure, contrarily to others who usually harvest four samples or less. [3,4,7,[10][11][12][13]18,[20][21][22][23][24]27] On the other hand, the collection of a greater number of samples may theoretically increase the chance of bleeding complications. However, intralesional hemorrhage occurred in a single occasion in this series (3.4%), which fortunately was asymptomatic and did not produce any mass effect (diameter = 10 mm).…”