Clinical Experience With Chlorpropamide and Comparative Evaluation With Tolbutamide

Fineberg, S. K.

doi:10.1111/j.1532-5415.1960.tb00408.x

Cited by 9 publications

(2 citation statements)

References 4 publications

(6 reference statements)

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“…Taking the types of patients into account, with all the attendant difficulties, a satisfactory response to chlorpropamide therapy in 56.6 per cent seems good enough to justify continued use of this oral hypoglycemic agent. This is a good response, even though it is lower proportionately than the good responses reported by others, such as Fineberg (8) (76 per cent favorable results), and Boyd and Grant (9) (71 per cent favorable results).…”

Section: Discussionmentioning

confidence: 49%

A Two and a Half Year Study of Chlorpropamide in a Large Outpatient Clinic

Parker

1963

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 49%

A Two and a Half Year Study of Chlorpropamide in a Large Outpatient Clinic

Parker

1963

J American Geriatrics Society

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“…The choice of drug is a matter of individual preference and judgment. It is incontrovertible that chlorpropamide is the most potent, and therefore the most effective, oral hypoglycemic agent available at present (29–31), but it carries slightly more risk of side‐effects than tolbutamide. For diabetes which is genuinely uncontrollable by diet alone, the greater potency of chlorpropamide is usually required.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Application of Newer Concepts in Diabetes*

Fineberg

1966

J American Geriatrics Society

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The changing definition of diabetes, brought up to date, includes the concepts of premellitus as well as mellitus, and of an enzymatically impaired or otherwise ineffective insulin as the possible cause of the full syndrome. Another current concept holds that an increased amount of this lipogenically active but glycolytically impaired insulin is the mechanism producing obesity in diabetes as a premellitic sign. Despite changed concepts the importance and effectiveness of prophylactic weight control in the premellitic stage, and as the fundamental treatment in all stages of obesity-diabetes remains the same. The order of preference in the addition of specific drugs to the dietary treatment of obesity-diabetes is anorexigenic agents, phenformin, single sulfonylureas, and combined chlorpropamide-phenformin. Insulin is the therapy of last resort in this usually mild form of diabetes. There is great potential usefulness for oral hypoglycemic combination therapy (with steroids temporarily if necessary) as a replacement for insulin in the treatment of immunologically-produced insulin resistance.

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An Evaluation of Long-Term Chlorpropamide Therapy

Benner¹

1965

JAMA

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Clinical Experience With Chlorpropamide and Comparative Evaluation With Tolbutamide

Cited by 9 publications

References 4 publications

A Two and a Half Year Study of Chlorpropamide in a Large Outpatient Clinic

A Two and a Half Year Study of Chlorpropamide in a Large Outpatient Clinic

Application of Newer Concepts in Diabetes*

An Evaluation of Long-Term Chlorpropamide Therapy

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