Clinical experience and safety using phosphatidylcholine injections for the localized reduction of subcutaneous fat: a multicentre, retrospective UK study

Palmer, Mark L.; Curran, John S.; Bowler, Patrick J

doi:10.1111/j.1473-2165.2006.00257.x

Cited by 46 publications

(30 citation statements)

References 22 publications

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“…The patient who developed diarrhea was injected with 1000mg dermastabilon / session. Similar results were reported by Palmer et al (38) Recommendation Research is still needed to determine whether an abbreviated behavioral intervention is efficacious.…”

Section: Resultssupporting

confidence: 78%

Assessment of Some Approaches for Weight Reduction Among Adult Females;an Interventional Study at Zagazig University Hospital

.Sheref

Salama

Sreaa

et al. 2014

Zagazig University Medical Journal

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Background: Obesity and overweight are growing global epidemic,Resulting in significant morbidity and mortality and reduce quality of life Managing one's weight is one factor in preventing chronic diseases Aim & Objectives: Assessment of some approaches for weight reduction to decrease the prevalence of obesity to avoid its inherent hazards ,through the following objectives1-To assess overweight and local obesity .2-To educate participants about healthy lifestyle(dietary habits).3-To apply diet restriction ,acupuncture and mesotherapy Courses . 4-to assess the effect of the previous approaches in preventing obesity. Subjects & Methods: An interventional study was conducted in obesity clinics at Zagazig University Hospital during the academic year between 2011 and 2012.This study designed to compare the weight reduction effects of 3 approaches (mesotherapy, acupuncture and diet restriction) versus control for 460 adult women with body mass index BMI <35, treated for 8 successive weeks and obesity indexes including body weight, BMI and waist/hip ratio(WHR) were evaluated. Versus baseline, The study was carried out through 3 phases Results:. the obesity indexes decreased at the end of each treatment course (diet and acupuncture)(p < 0.05), while no decrease at BMI at the end of the mesotherapy course(p>0.05) with significant reduction at WHR (p<0.01). Conclusion: This study revealed that, that acupuncture then dietary caloric restriction reduced body weight while mesotherapy are effective body contouring approaches .

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Section: Resultssupporting

confidence: 78%

Assessment of Some Approaches for Weight Reduction Among Adult Females;an Interventional Study at Zagazig University Hospital

.Sheref

Salama

Sreaa

et al. 2014

Zagazig University Medical Journal

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“…Sollte sich dabei eine lymphogene Metastasierung bestätigen, scheint die radikale Lymphknotendissektion mit konsekutiver Radiatio das rezidivfreie Überleben zu verlängern. Evidente Daten zu einer adjuvanten Chemotherapie oder zu alternativen Therapieoptionen (hypertherme Extremitätenperfusion) liegen aktuell noch nicht vor und sind somit Patienten mit Rezidiven respektive Organmetastasen vorbehalten [1,6].…”

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Schwere toxische Dermatitis nach Injektionslipolyse

et al. 2012

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The subcutaneous injection of phosphatidylcholine-containing substances is a frequently used method to reduce small localized fat deposits. Even though injection lipolysis is generally safe and free of complications, there have been rare reports on poor results, hematoma, infection or localized skin and tissue necrosis. A 28-year-old woman presented with an extensive toxic dermatitis characterized by well defined, erythematous, partly livid plaques as well as severe edema and strong pain about eighteen days after injection lipolysis on the thighs and knees.

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“…Adipocytolysis by Phosphatidylcholine 39 vey of 10,518 treatments [20]. Unfortunately, no efficacy data were provided in this report, and no histological findings analyzed.…”

Section: Discussionmentioning

confidence: 77%

Compounds Used for ‘Injection Lipolysis’ Destroy Adipocytes and other Cells Found in Adipose Tissue

Janke¹,

Engeli²,

Gorzelniak³

et al. 2009

Obes Facts

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Background: A widely applied technique to reduce subcutaneous fat pad size involves subcutaneous injection of a phosphatidylcholine preparation (‘injection lipolysis’). As the mode of action is mostly unknown, we planned to study cellular effects of the particular drug used in Germany (Lipostabil®). Methods: Human preadipocytes, adipocytes, vascular and skeletal muscle cells as well as renal epithelial cells were incubated in the compound, morphological changes were described, and cell vitality was measured. Results: A strong cytolytic effect of the compound was signified by lipid release and acridine orange staining of dying adipocyte nuclei. When the undiluted compound was used, more than 90% of cell death occurred after 90 s in preadipocytes, after 6 min in vascular smooth muscle cells, skeletal myotubes and renal epithelial cells, and after 15 min in adipocytes. Dilution slowed down cytolysis, but still >50% of the cells disappeared during 30 min incubation. Neither osmotic effects nor differences in medium acidity were responsible for cell death. Conclusion: Injection lipolysis with phosphatidylcholine as the major injected compound reduces subcutaneous fat pad size through cell and tissue destruction. Beside the lack of a clear risk-benefit analysis, applying this technique represents off-label drug use and application of a drug by a contraindicated route.

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Clinical experience and safety using phosphatidylcholine injections for the localized reduction of subcutaneous fat: a multicentre, retrospective UK study

Abstract: This treatment appears to be associated with minimal risks when used by specifically trained and experienced doctors. The possible risks associated with this treatment should be balanced against the risks of other treatment options.

Cited by 46 publications

References 22 publications

Assessment of Some Approaches for Weight Reduction Among Adult Females;an Interventional Study at Zagazig University Hospital

Assessment of Some Approaches for Weight Reduction Among Adult Females;an Interventional Study at Zagazig University Hospital

Schwere toxische Dermatitis nach Injektionslipolyse

Compounds Used for ‘Injection Lipolysis’ Destroy Adipocytes and other Cells Found in Adipose Tissue

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