Clinical Examination of Tissue Eosinophilia in Patients with Chronic Rhinosinusitis and Nasal Polyposis

Gitomer, Sarah A.; Fountain, Cynthia R.; Kingdom, Todd T.; Getz, Anne E.; Sillau, Stefan; Katial, Rohit; Ramakrishnan, Vijay R.

doi:10.1177/0194599816637856

Cited by 34 publications

(47 citation statements)

References 42 publications

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“…The eosinophil count (70 cells/HPF) used in this study as the definition of ECRS is considerably higher than in earliest studies . On the other hand, it was reported that tissue eosinophilia did not predict disease severity in the retrospective analysis of CRSwNP patients . Therefore, there are no clear criteria for tissue eosinophilic infiltration for use in diagnosing ECRS.…”

Section: Discussionmentioning

confidence: 99%

Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non‐eosinophilic chronic rhinosinusitis

Okada

Nakayama

Asaka

et al. 2018

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 99%

Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non‐eosinophilic chronic rhinosinusitis

Okada

Nakayama

Asaka

et al. 2018

Int Forum Allergy Rhinol

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“…The authors concluded that patients with more than 10% of eosinophils in their peripheral blood had a significantly higher disease recurrence rate than those with up to 10% of eosinophils. Gitomer et al . assessed a series of patients treated for CRSwNP from 2008 to 2010, and found that serum eosinophilia did not predict disease severity.…”

Section: Discussionmentioning

confidence: 99%

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Brescia

Barion

Zanotti

et al. 2016

Int Forum Allergy Rhinol

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“…In fact, eosinophilia was a reliable marker for severe and refractory sinusitis. Some studies focusing on the degree of tissue eosinophilia in chronic sinusitis and its bearing on the severity of CRS, which revealed the presence of peripheral eosinophilia in patients with sinusitis, indicated a high likelihood of extensive disease [9], but neither serum nor tissue eosinophilia predicted disease severity in CRSwNP patients [10, 11]. Sinonasal tissue eosinophilia is present in the majority of CRSwNP patients but it is currently more common in the West than in the East [12].…”

Section: Introductionmentioning

confidence: 99%

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

Chen

Qiao

et al. 2019

Int Arch Allergy Immunol

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Background: Nasal polyps are a common health problem that can significantly impact the quality of life. Objective: To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. Methods: A retrospective cohort of 323 patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP in Xijing Hospital was studied between January 5, 2011, and January 4, 2015. All of the patients underwent an allergen skin prick test and peripheral blood EOS inspection. Detailed information regarding the impact of allergy and EOS on the morbidity of CRSwNP was collected. Potential risk factors associated with nasal polyps were explored using logistic regression analysis. Multivariate logistic regression was performed to identify independent risk factors. Results: The results revealed that EOS is an important risk factor for nasal polyps. In the univariate analysis, the adjusted OR was 2.01 (95% CI 1.08–3.72; p = 0.027). In the multivariate analysis, the adjusted OR was 2.02 (95% CI 1.08–3.76; p = 0.027). Compared to allergic rhinitis and normal EOS levels, nonallergic rhinitis and elevated EOS levels constituted a risk factor for CRSwNP (OR = 2.70; 95% CI 1.32–5.50). Compared to allergen-positive and EOS-normal status, allergen-negative and elevated-EOS status constituted a risk factor for CRSwNP (OR = 2.95; 95% CI 1.38–6.33). Conclusion: EOS is a significant factor related to the morbidity of CRSwNP in Northwest China. Elevated EOS levels occurring in the context of nonallergic rhinitis constitute a risk factor for CRSwNP. Similarly, elevated EOS levels occurring in the context of allergen-negative rhinitis are also an important risk factor for morbidity of CRSwNP.

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Clinical Examination of Tissue Eosinophilia in Patients with Chronic Rhinosinusitis and Nasal Polyposis

Abstract: Higher serum eosinophil levels may indicate more extensive mucosal disease as measured on CT scan. Neither serum nor tissue eosinophilia predicted disease severity in our retrospective analysis of CRSwNP patients, and serum eosinophil level did not serve as a marker of tissue eosinophilia.

Cited by 34 publications

References 42 publications

Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non‐eosinophilic chronic rhinosinusitis

Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non‐eosinophilic chronic rhinosinusitis

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

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