Clinical Evaluations of a Histologic Examination of the Side Effects of Myelographic Contrast Media

Abstract

Side effects following myelography with positive contrast media have been reported with varying frequency and have usually been ascribed to meningeal reaction. An experimental histologic examination of the spinal cord, nerve roots and meninges after myelography with iodophendylate and methiodal was undertaken.The results of this investigation will be briefly summarized with special reference to the roentgenologic findings. Comparison will be made to complications in myelography in human subjects and precautions necessary in this procedure will be suggested. ResultsIodophendylate. Thirty-four rats weighing 250 ± 40 g were injected with 0.15 ml iodophendylate (Pantopaque) by suboccipital puncture. The amount was calculated to the proportional weight of the spinal cord in rats and men and

Potential complications in myelography: I. Technical considerations

“…The literature is replete with various theories on possibl e mechanisms for production of arachnoiditis includ ing hypersensitivity, chemi cal irritation, infection, spinal anesthetics , surgical procedures, hemorrhage , etc. [4][5][6][7][8][10][11][12][13][14][15]. Bergeron et al [11] implicated retained Pantopaque in the production of arac hnoid al reaction.…”

Arachnoiditis and epidural fibrosis: the Relationship to chronic pain

“…Jakobsen [65] produced arachnoiditis in rats using iophendylate with and without blood, and followed the animals for up to 120 days. He noted: "the rats were clinically inactive the first days after the injection of contrast medium, but were without any signs of paralysis and without any further signs during the rest of the experimental period.…”