Clinical evaluation of urolithiasis in Crohn's disease

Abstract

Objectives:To investigate the characteristics of urolithiasis associated with Crohn's disease in a Japanese population. Methods: We studied 98 patients with Crohn's disease: 39 with urolithiasis and 59 without urolithiasis. Patients were treated at the Social Insurance Central General Hospital, or at the Toho University Omori, Ohashi, or Sakura Medical Centers. Results: Calculi were more frequent in men (n = 30) than women (n = 9). Mean time from diagnosis of Crohn's disease to diagnosis of calculi was 8.8 years (range 0 to 22 years). Calculi were present on the right side in 19 patients and the left side in 19 patients. Stone were composed of calcium oxalate in nine patients, calcium oxalate and calcium phosphate in two patients, and ammonium urate in five patients. The rate of concurrent calculi was significantly higher in ileostomates. The probability of developing calculi was approximately eight times higher for patients with a urine pH of Յ6.0 than for those with a urine pH of Ն6.5. Conclusions: The rate of concurrent urolithiasis was higher in patients with a urine pH of Յ6.0, ileostomy, or two or more bowel resections. To prevent formation of calculi, Crohn's disease patients require regular urological examination including urinalysis, ultrasonography, and kidney ureter bladder X-ray.

Crohn’s disease: prevalence of intestinal and extraintestinal manifestations detected by computed tomography enterography with water enema

“…The prevalence of nephrolithiasis in CD patients compared to the general population is increased, with a reported incidence of 5%-19% [32]. We found a prevalence of 4% and no cases of hydroureteronephrosis.…”

Urolithiasis in inflammatory bowel disease and bariatric surgery

“…The commonest type of stone was calcium oxalate. The probability of developing calculi was approximately eight times higher for patients with a urine pH of ≤ 6.0 than for those with a urine pH of ≥ 6.5[13]. …”

Incidence and Risk Factors for Urolithiasis in Patients with Crohn's Disease

“…The lifetime prevalence is estimated to be 5-10% [8,9,10]. Because of the increasing number of patients with CD in Asia, the prevalence of urolithiasis in patients with CD is anticipated to grow [11]. Pardi et al [12] reported the risk of developing urolithiasis in patients with CD is 10-100 times greater than the risk for general hospital patients.…”