Clinical evaluation of the zona‐free hamster egg penetration test in the management of the infertile couple. Prospective and retrospective studies

Irvine, D. Stewart; Aitken, R. John

doi:10.1111/j.1365-2605.1986.tb00948.x

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…, 1987; Soffer et al. , 1992) and the achievement of spontaneous pregnancy in long‐term prospective studies involving patients exhibiting unexplained infertility (Irvine & Aitken, 1986a,b; Shy et al. , 1988; Aitken et al.…”

Section: The Zona‐free Hamster Oocyte Penetration Assaymentioning

confidence: 99%

Sperm function tests and fertility

2006

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Traditionally, the diagnosis of male infertility has depended upon a descriptive evaluation of human semen with emphasis on the number of spermatozoa that are present in the ejaculate, their motility and their morphology. The fundamental tenet underlying this approach is that male fertility can be defined by reference to a threshold concentration of motile, morphologically normal spermatozoa that must be exceeded in order to achieve conception. Many independent studies have demonstrated that this fundamental concept is flawed and, in reality, it is not so much the absolute number of spermatozoa that determines fertility, but their functional competence. In the light of this conclusion, a range of in vitro tests have been developed to monitor various aspects of sperm function including their potential for movement, cervical mucus penetration, capacitation, zona recognition, the acrosome reaction and sperm-oocyte fusion. Such functional assays have been found to predict the fertilizing capacity of human spermatozoa in vitro and in vivo with some accuracy. Recent developments in this field include the introduction of tests to assess the degree to which human spermatozoa have suffered oxidative stress as well as the integrity of their nuclear and mitochondrial DNA. Such assessments not only yield information on the fertilizing capacity of human spermatozoa but also their ability to support normal embryonic development.

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Section: The Zona‐free Hamster Oocyte Penetration Assaymentioning

confidence: 99%

Sperm function tests and fertility

2006

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“…There are several explanations as to why slow or sluggish linear or nonlinear motility is superior. Recent work with photomicrography (Cohen et al, 1982;Aitken et al, 1984;Irvine & Aitken, 1986a& 1986b has suggested that very rapid linear spermatozoal motion may be less effective. This might be explained owing to an association between a low amplitude of lateral head displacement and very rapid linear spermatozoal velocity (David et al,,198 1).…”

Section: Discussionmentioning

confidence: 99%

The importance of employing stringent methods to recruit fertile male controls

et al. 2009

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Two methods of recruiting fertile male controls were evaluated and compared. The first group was recruited from the partners of women attending an antenatal clinic without obtaining details of their reproductive history. The second group was recruited after obtaining a detailed reproductive history from the couple and employing stringent entry criteria. Entry criteria for the second group included a length of exposure to the risk of pregnancy of not more than 12 months and no previous episode of involuntary infertility for either partner. There were significant differences between the distributions of semen parameters obtained from the two groups, indicating that the selection criteria for "fertile" men significantly influence results obtained and therefore that it is important to employ stringent criteria for the recruitment of fertile male controls. The group which was recruited by stringent criteria (mean length of exposure to the risk of pregnancy of 3 months) was characterised by a significantly higher median concentration of spermatozoa which exhibited slow linear or nonlinear motility. This confirms the findings of a previous study which suggested that slow linear or nonlinear motility are superior forms of spermatozoal motion.

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Donor Insemination

Irvine¹,

Templeton²

1994

Male Infertility

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Clinical evaluation of the zona‐free hamster egg penetration test in the management of the infertile couple. Prospective and retrospective studies

Cited by 5 publications

References 28 publications

Sperm function tests and fertility

Sperm function tests and fertility

The importance of employing stringent methods to recruit fertile male controls

Donor Insemination

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