Clinical Evaluation of the Tolerability and Efficacy of Trovafloxacin Compared with Sparfloxacin in the Treatment of Lower Respiratory Tract Infections

Abstract

Trovafloxacin is well tolerated and effective in the treatment of lower respiratory tract infections in a dosage of 200mg daily. It was observed that the efficacy and tolerability of trovafloxacin is comparable to that of sparfloxacin (200mg daily, with a loading dose of 400mg on the first day) in the treatment of lower respiratory tract infections. However, further studies are needed to confirm this.

Chemistry and biological activities of 1,8-naphthyridines

“…In 70% DMF, the ionisation constants of naphthyridones 175a,b depend on the size of the saturated cyclic fragments of the molecules, which is associated with steric factors, such as a change in steric accessibility of the polar groups of the cationic (A) and anionic (B) forms to solvation. 404 1,8-Naphthyridinones were also synthesised starting from 6-aminopyridin-2-one (176). 405 Its condensation with enones 177 in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in DMF afforded ethyl 2-oxo-1,8-naphthyridine-6-carboxylate (178).…”