Clinical Evaluation of Reduced Field-of-View Diffusion-Weighted Imaging of the Cervical and Thoracic Spine and Spinal Cord

Andre, Jalal B.; Zaharchuk, Greg; Sarıtaş, Emine Ülkü; Komakula, S.; Shankaranarayan, A.; Banerjee, Suchandrima; Rosenberg, Jarrett; Nishimura, Dwight G.; Fischbein, Nancy J.

doi:10.3174/ajnr.a3134

Cited by 36 publications

(27 citation statements)

References 19 publications

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“…The ADC values of thyroid glands calculated based on the rFOV DWI images in our study were significantly lower than those calculated based on fFOV DWI images, unlike some previous studies in the spine that did not find a significant difference in ADC values between the rFOV and fFOV DWI techniques 16, 19 . However, in a study of pretreatment DWI of breast cancer, significantly lower values of the 15 th -percentile tumor ADC (p=0.03) were found in rFOV DWI 20 .…”

Section: Discussioncontrasting

confidence: 99%

“…The susceptibility artifacts were dramatically decreased in rFOV DWI images. Similar findings have been reported that recommend a strong preference for rFOV DWI on the basis of reduction of susceptibility artifacts 16, 19 .…”

Section: Discussionsupporting

confidence: 89%

“…The rFOV DWI technique was originally applied in spinal cord diffusion imaging 16, 19 and then extended to other anatomies 20 . In order to translate the technique into clinical and quantitative investigation on thyroid patients, a comprehensive evaluation of its repeatability is warranted.…”

Section: Discussionmentioning

confidence: 99%

“…The reduced field-of-view (rFOV) DWI technique using two-dimensional spatially selective excitation, which excites only the region of interest (ROI), has shown its effectiveness in providing high quality images with less artifacts, and therefore supplying more reliable QIBs 15–19 . This technique has been assessed previously in several human organs, such as spinal cords 15, 16, 19 , pancreas 18 and breasts 17, 20, 21 . In order to translate the technique into clinical application and quantitative investigation in thyroid glands, a comprehensive evaluation of its repeatability is imperative.…”

Section: Introductionmentioning

confidence: 99%

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Repeatability Investigation of Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging on Thyroid Glands

Hatzoglou

Banerjee

et al. 2015

Journal of Computer Assisted Tomography

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Objective To investigate the repeatability of the quantitative magnetic resonance imaging (MRI) metric (apparent diffusion coefficient (ADC)) derived from reduced field-of-view diffusion-weighted (rFOV DWI) on thyroid glands in a clinical setting. Materials and Methods Ten healthy human volunteers were enrolled in MRI studies performed on a 3T MRI scanner. Each volunteer was designed to undergo 3 longitudinal exams (2 weeks apart) with 2 repetitive sessions within each exam, which included rFOV and conventional full field-of-view (fFOV) DWI scans. DWI images were assessed and scored based on image characteristics. ADC values of thyroid glands from all subjects were calculated based on regions of interest. Repeatability analysis was performed based on the framework proposed by the Quantitative Imaging Biomarker Alliance (QIBA), generating four repeatability metrics: within-subject variance (σw2), repeatability coefficients (RC), intraclass correlation coefficient (ICC) and within-subject coefficient of variation (wCV). Student t test was employed to compare the performance difference between rFOV and fFOV DWI. Results The overall image quality from rFOV DWI was significantly higher than that from fFOV DWI (p=0.04). The ADC values calculated from rFOV DWI were significantly lower than corresponding values from fFOV DWI (p<0.001). There was no significant difference in ADC values across sessions and exams in either rFOV or fFOV DWI (p>0.05). rFOV DWI had lower values of σw2, RC, and wCV and a higher value of ICC compared to fFOV DWI either across sessions and exams. Conclusion This study demonstrated that rFOV DWI produced more superior quality DWI images and more repeatable ADC measurements compared to fFOV DWI, thus providing a feasible quantitative imaging tool for investigating thyroid glands in clinical settings.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Repeatability Investigation of Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging on Thyroid Glands

Hatzoglou

Banerjee

et al. 2015

Journal of Computer Assisted Tomography

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“…This sequence permits decreasing the required readout duration for ss-EPI, thereby showing better anatomical details and obtaining better diffusion-weighted (DW) images [10]. The FOCUS technique has been shown to decrease image distortion and adding diagnostic value in adult spinal cord, breast, and prostate [11][12][13].…”

Section: Introductionmentioning

confidence: 98%

Comparison of field-of-view (FOV) optimized and constrained undistorted single shot (FOCUS) with conventional DWI for the evaluation of prostate cancer

et al. 2015

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MRI in transverse myelitis

Goh

Desmond

Phal

2014

Magnetic Resonance Imaging

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Transverse myelitis is an acute inflammatory disease of the spinal cord, characterized by rapid onset of bilateral neurological symptoms. Weakness, sensory disturbance, and autonomic dysfunction evolve over hours or days, most progressing to maximal clinical severity within 10 days of onset. At maximal clinical severity, half will have a paraparesis, and almost all patients have sensory disturbance and bladder dysfunction. Residual disability is divided equally between severe, moderate and minimal or none. The causes of transverse myelitis are diverse; etiologies implicated include demyelinating conditions, collagen vascular disease, and parainfectious causes, however, despite extensive diagnostic work-up many cases are considered idiopathic. Due to heterogeneity in pathogenesis, and the similarity of its clinical presentation with those of various noninflammatory myelopathies, transverse myelitis has frequently been viewed as a diagnostic dilemma. However, as targeted therapies to optimize patient outcome develop, timely identification of the underlying etiology is becoming increasingly important. In this review, we describe the imaging and clinical features of idiopathic and disease-associated transverse myelitis and its major differentials, with discussion of how MR imaging features assist in the identification of various sub-types of transverse myelitis. We will also discuss the potential for advanced MR techniques to contribute to diagnosis and prognostication.

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Clinical Evaluation of Reduced Field-of-View Diffusion-Weighted Imaging of the Cervical and Thoracic Spine and Spinal Cord

Abstract: BACKGROUND AND PURPOSE: DWI has the potential to improve the detection and evaluation of spine and spinal cord pathologies. This study assessed whether a recently described method (rFOV DWI) adds diagnostic value in clinical patients.

Cited by 36 publications

References 19 publications

Repeatability Investigation of Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging on Thyroid Glands

Repeatability Investigation of Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging on Thyroid Glands

Comparison of field-of-view (FOV) optimized and constrained undistorted single shot (FOCUS) with conventional DWI for the evaluation of prostate cancer

MRI in transverse myelitis

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