Clinical evaluation of polyethersulfone high‐flux hemodialysis membrane compared to other membranes

Su, Baihai; Shi, Yunying; Fu, Ping; Tao, Ye; Nie, Shengqiang; Zhao, Changsheng

doi:10.1002/app.35589

Cited by 10 publications

(7 citation statements)

References 26 publications

(21 reference statements)

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“…This finding is similar to an earlier study that concluded a pore density of 10% in Hemophan membrane [18]. A recent study of polyethersulfone (PES) [1] demonstrated the unsatisfactory pore shape of the PES membrane. The study did not estimate the pore density, however.…”

Section: Discussionsupporting

confidence: 90%

Morphological Characterization of the Polyflux 210H Hemodialysis Filter Pores

Hedayat

Szpunar

Kumar

et al. 2012

International Journal of Nephrology

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Background. Morphological characterization of hemodialysis membranes is necessary to improve pore design. Aim. To delineate membrane pore structure of a high flux filter, Polyflux 210H. Methods. We used a Joel JSM-6010LV scanning electron microscope (SEM) and a SU6600 Hitachi field emission scanning electron microscope (FESEM) to characterize the pore and fiber morphology. The maximal diameters of selected uremic toxins were calculated using the macromolecular modeling Crystallographic Object-Oriented Toolkit (COOT) software. Results. The mean pore densities on the outermost and innermost surfaces of the membrane were 36.81% and 5.45%, respectively. The membrane exhibited a tortuous structure with poor connection between the inner and outer pores. The aperture's width in the inner surface ranged between 34 and 45 nm, which is 8.76–11.60 times larger than the estimated maximum diameter of β2-microglobulin (3.88 nm). Conclusion. The results suggest that the diameter size of inner pore apertures is not a limiting factor to middle molecules clearance, the extremely diminished density is. Increasing inner pore density and improving channel structure are strategies to improve clearance of middle molecules.

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Section: Discussionsupporting

confidence: 90%

Morphological Characterization of the Polyflux 210H Hemodialysis Filter Pores

Hedayat

Szpunar

Kumar

et al. 2012

International Journal of Nephrology

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“…The most important advantages that make PSf useful in HD are: -high biocompatibility; -high permeability for low molecular-weight proteins; -high retention of endotoxins; -the possibility of trouble-free sterilization. 10 Such membranes also have some disadvantages. They can cause protein accumulation on the surface of the membrane, which results in reduced flow and changes in membrane selectivity.…”

Section: Chemical Composition and Its Influence On Membrane Performancementioning

confidence: 99%

Dialysis membranes: A 2018 update

Olczyk¹,

Małyszczak²,

Kusztal³

2018

Polim. Med.

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Dialysis membranes are the basic element of a hemodialyzer. Synthetic and natural materials characterized by various fiber arrangements are used in their production. The most up-to-date ones are made of synthetic polymers such as polyamide, phosphatidylserine (PS), polyacrylonitrile-based fiber (PAN), polyarylethersulfone, polyethersulfone, or polymethylmethacrylate. Dialysis membranes are characterized by the ability to remove uremic molecules, which can be divided into small water-soluble compounds, protein-bound compounds and larger "middle molecules". Newer membranes such as medium cut off membranes (MCO) allow the removal of a wider spectrum of uremic molecules, which reduces the risk of late complications of dialysis. Dialysis membranes are used in therapy methods such as low flux, high flux or HDx therapy. An important aim in dialysis membrane development is to increase their biocompatibility. Insufficient biocompatibility can result in complement activation or platelet activation, which can lead to an increased risk of cardiovascular complications. The aim of the study is to discuss the latest reports on dialysis membranes.

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“…With very large molecular size, vitamin B 12 might hinder creatinine and urea to enter the membrane pores [13][14]. The competition of the three metabolites to approach the membrane surface may also cause additional collision between the molecules, so that it is difficult for creatinine and urea to enter the membrane pores which lead to so longer transport time.…”

Section: The Effects Of Vitamin B 12 On the Transport Of Creatinine Amentioning

confidence: 99%

THE INFLUENCE OF PVA.cl.CITRIC ACID/CHITOSAN MEMBRANE HYDROPHICILITY ON THE TRANSPORT OF CREATININE AND UREA

Lusiana¹,

Siswanta²,

Mudasir³

et al. 2013

Indones. J. Chem.

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The influence of cross-linking and membrane hydrophilicity on the transport rate had been studied using a membrane prepared from a mixture of chitosan/PVA cross-linked citric acid (PVA.cl.CA) for creatinine and urea transport. The optimum mole ratio of PVA:citric acid as well as the best composition of chitosan:PVA.cl.CA were determined using creatinine transport study. Using the optimum compositions, further study was done using different thickness of the membrane in transporting creatinine, urea and a mixture of 3 species (creatinine, urea and vitamin B 12

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Clinical evaluation of polyethersulfone high‐flux hemodialysis membrane compared to other membranes

Cited by 10 publications

References 26 publications

Morphological Characterization of the Polyflux 210H Hemodialysis Filter Pores

Morphological Characterization of the Polyflux 210H Hemodialysis Filter Pores

Dialysis membranes: A 2018 update

THE INFLUENCE OF PVA.cl.CITRIC ACID/CHITOSAN MEMBRANE HYDROPHICILITY ON THE TRANSPORT OF CREATININE AND UREA

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