Clinical evaluation of platelet‐rich plasma and bioactive glass in the treatment of intra‐bony defects

Abstract

It is suggested that both PRP/BG combination and BG alone are effective in the treatment of intra-bony defects. The results also showed that using PRP with BG has no additional benefit in the reduction of pocket depth, clinical attachment gain and defect fill.

Comparative evaluation of bioactive glass bone graft material with platelet rich fibrin and bioactive glass bone graft material alone for the treatment of periodontal intrabony defects: a clinical and radiographic study

“…4,22 It was with these factors keeping in mind that the present study was planned to evaluate, and to compare the clinical and radiographic outcomes obtained by a combination of bioactive glass bone Graft with PRF and bioactive glass Bone Graft alone in treatment of periodontal intrabony defects. Twenty defects were randomly allocated in the test and control group.…”

“…Among the grafts, only autogenous bone grafts provide viable osteogenic cells. 2,4 However, the routine use of autografts in regenerative periodontal treatment is limited. To overcome these problems, use of other materials such as allografts, xenografts or alloplasts have been proposed.…”

“…Clinical and histological studies have indicated that bioactive glass not only results in gain in clinical attachment and radiographic fill of osseous defects, but may also act as a barrier retarding the down growth of the epithelium. 4,5 Growth factors that seem to play an important role in periodontal and bone wound healing are platelet derived growth factor (PDGF), insulin-like growth factor (IGF) combined with PDGF and transforming growth factor ß (TGF-ß). 1,7 Platelet-rich fibrin (PRF) can stimulate cell proliferation.…”

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

“…But when the local conditions are not optimum, PRP gels alone are not strong enough to promote a clinical filling equivalent to the dense bone filling reached with a bone substitute [50]. Most of the randomized controlled clinical trials(RCTs) demonstrated that the addition of PRP to certain regenerative materials, doi: 10.7243/2050-1218-2-11 namely bioactive glass [51], b-TCP [52], BM and e-PTFE membranes [53], b-TCP and e-PTFE membranes [54], BM and collagen membranes [23] and BM and EMD [55], failed to confer statistically significant additive benefits in the therapy of periodontal intraosseous defects. However, according to other RCTs such adjunctive positive outcomes may result from other combinations of PRP, namely together with BM [28], DFDBA [56] and hydroxyapatite [22].…”

Efficacy of Periodontal Stem Cell Transplantation in the Treatment of Advanced Periodontitis

“…tissue regeneration (GTR), topical application of enamel matrix derivative (EMD), or various growth factors can partially regenerate periodontal tissues (8,10,11,14,15, Oral diseases are included among the World Health Organization (WHO) definition of chronic diseases, and 27,30). The results in clinical applications vary greatly, depending on the different characteristics of the defects the associations between oral health status and chronic systemic diseases have been observed recently (48,49).…”