Clinical evaluation of medications on oral and dental health

Peker, İlkay; Alkurt, Meryem Toraman; Usalan, Gülten

doi:10.1111/j.1875-595x.2008.tb00352.x

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…This study confirmed the results of a previous study by the same investigators conducting this study [31]. Conversely, Janket et al, [65] found no significant increase in coronal caries prevalence among 345 male veterans taking xerostomic medications versus those taking non-xerostomic medications. However, Janket and colleagues did not confirm the presence of saliva hypofunction in either the xerostomic or non-xerostomic medications groups in this veteran's administration's outpatient population.…”

Section: Discussionsupporting

confidence: 83%

“…Peker et al, [65] compared a medicated to a non-medicated group that exhibited statistically significant differences (p<0.05) between the groups for dental caries, amalgam, fixed and removable prosthetic restorations and missing teeth. This study confirmed the results of a previous study by the same investigators conducting this study [31].…”

Section: Discussionmentioning

confidence: 99%

“…Similar to Thomson et al, finding, proton pump inhibitors also demonstrated a high level of total carious lesions, which is consistent with data reported for both Australian and Swedish populations [23,64]. A contributor to the caries prevalence in this group may be related to gastroesophageal reflux, which is known to cause demineralization of the teeth and should be further assessed.Peker et al, [65] compared a medicated to a non-medicated group that exhibited statistically significant differences (p<0.05) between the groups for dental caries, amalgam, fixed and removable prosthetic restorations and missing teeth. This study confirmed the results of a previous study by the same investigators conducting this study [31].…”

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confidence: 99%

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Prevalence of Dental Carious Lesions with Different Classes of Medications

Singh¹

2015

GGM

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Background: Past research has produced conflicting results concerning the usage of medications and the associated oral health consequences. The authors examined non-cavitated and cavitated coronal and root carious lesions among subjects taking a variety of medications compared to those taking no medications to assess whether the effects of taking multiple medications had on carious lesion prevalence.Objective: The objective of this study was to assess how the different classes of medication adversely affected the oral cavity, specifically in the formation of dental carious lesions.Methods: A representative sample of 1028 volunteers aged 40-80 from the Greater Boston area, with at least 10 natural teeth were included in this study. After disqualifying subjects on medications with autoimmune conditions known to cause xerostomia, or a previous history of radiation to the head and neck area, 882 volunteers on medications known to cause salivary hypofunction and 146 volunteers taking no medications were enrolled. Non-cavitated and cavitated carious lesions were examined by a single calibrated dental examiner using visual and tactile methods. Major medication groups included psychiatric (N=258), single antihypertensive (N=180), multiple antihypertensive including cardiac medications (N=145), a combination of antihypertensive and psychiatric medications (N=85), anti-asthma medications (N=67), Non-Steroidal Anti-Inflammatory (NSAIDs) (N= 34) and all other medications (N=113).Results: Subjects on psychiatric medications had the highest number of total carious lesions (5.4±4.94) while those taking no medications had the least (2.6±2.92). Subjects on a combination of antihypertensive and psychiatric medications had the highest number of carious root surface lesions (1.18±4.06). Those subjects on anti-asthma medications exhibited the highest number of cavitated coronal surface lesions (1.41±2.06). Conclusion:This study found xerostomic medications vary in their deleterious effects on dental carious lesions. A combination of antihypertensive and psychiatric medications is the most detrimental, as evidenced by a higher prevalence of carious lesions in those participants taking them.Clinical significance: As usage of concomitant xerogenic medications is likely to continue to increase, educating clinicians and the general public about the effects on oral health is essential to limiting dental carious lesions by instituting appropriate preventive protocols. Keywords: Dental carious lesions; Medications; Side effectsCitation: Singh M, Papas AS, Papas AN, Barker ML, Biesbrock A (2015) [7,13,14,[21][22][23][24][25][26][27][28][29][30][31].Past research has produced conflicting results concerning a link between asthma medications and caries incidence. Meldrum et al., [32] found no significant differences in caries increment between asthma-free and asthma subjects. However, only 42.4% of the asthma subjects used anti-asthma medications, indicating that the medication rather than the condition may play a role. Consistent wi...

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Prevalence of Dental Carious Lesions with Different Classes of Medications

Singh¹

2015

GGM

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“…Patients presenting for dental care frequently use medications that have potentially negative effects on oral health or on the dental provider's plan of care. Medications may affect oral health through their orofacial effects (causing xerostomia, mouth ulceration, oral candidiasis, etc.)…”

Section: Introductionmentioning

confidence: 99%

Medication discrepancies in the dental record and impact of pharmacist-led intervention

Choi

Stewart

2017

International Dental Journal

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“…In a randomized controlled trial, Peker et al (2009) compared healthy patients not taking medication with patients taking medications, and found that the population on medications had statistically significant bleeding and dryness, which Paker et al associated with the increased amount of missing teeth when compared to the population not taking medications. 17,18 On the other hand there are drugs that have a favorable biological effect on bone height, such as antibiotics. Metformin is another drug associated with PD reduction and CAL gain when it was used in addition to scaling and root planning.…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between periodontal conditions and number of medications among the elderly?

Natto¹,

Aladmawy²,

Alshaeri³

et al. 2016

Ghana Medical Journal

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SUMMARYObjective: To investigate possible correlations of clinical attachment level and pocket depth with number of medications in elderly individuals. Methods: Intra-oral examinations for 139 patients visiting Tufts dental clinic were done. Periodontal assessments were performed with a manual UNC-15 periodontal probe to measure probing depth (PD) and clinical attachment level (CAL) at 6 sites. Complete lists of patients' medications were obtained during the examinations. Statistical analysis involved Kruskal-Wallis, chi square and multivariate logistic regression analyses. Results: Age and health status attained statistical significance (p< 0.05), in contingency table analysis with number of medications. Number of medications had an effect on CAL: increased attachment loss was observed when 4 or more medications were being taken by the patient. Number of medications did not have any effect on periodontal PD. In multivariate logistic regression analysis, 6 or more medications had a higher risk of attachment loss (>3mm) when compared to the no-medication group, in crude OR (1.20, 95% CI:0.22-6.64), and age adjusted (OR=1.16, 95% CI:0.21-6.45), but not with the multivariate model (OR=0.71, 95% CI:0.11-4.39). Conclusion: CAL seems to be more sensitive to the number of medications taken, when compared to PD. However, it is not possible to discriminate at exactly what number of drug combinations the breakdown in CAL will happen. We need to do further analysis, including more subjects, to understand the possible synergistic mechanisms for different drug and periodontal responses.

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Clinical evaluation of medications on oral and dental health

Abstract: There was a statistically significant difference for self-reported oral dryness and gingival bleeding and these factors may have been influenced by the increased rate of missing teeth and prosthetic restorations in the medication group.

Cited by 13 publications

References 19 publications

Prevalence of Dental Carious Lesions with Different Classes of Medications

Prevalence of Dental Carious Lesions with Different Classes of Medications

Medication discrepancies in the dental record and impact of pharmacist-led intervention

Is there a relationship between periodontal conditions and number of medications among the elderly?

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