Clinical evaluation of lipids, lipoproteins and red blood cells sodium and potassium in patients with different grades of hypertension

Aribi, Mourad; Merzouk, Hafida; Haddouche, Mustapha; Benyoucef, Mohammed; Taleb, A.; Kendouci-Tani, Mohammed; Merzouk, Sid Ahmed; Meziane, Abderrahim

doi:10.1016/j.clinbiochem.2010.05.012

Cited by 5 publications

(4 citation statements)

References 49 publications

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“…The bulk concentrations used in the simulation for Na + , K + , and Cl – are shown in Table . The sodium and potassium concentrations in the intracellular and extracellular environments as well as intracellular chloride are in accordance with the experimental data obtained by Funder and Wieth , and Aribi and collaborators . The chloride concentration in the extracellular environment was obtained through the principle of electroneutrality.…”

Section: Modeling and Theorysupporting

confidence: 87%

“…The sodium and potassium concentrations in the intracellular and extracellular environments as well as intracellular chloride are in accordance with the experimental data obtained by Funder and Wieth 41,42 and Aribi and collaborators. 43 The chloride concentration in the extracellular environment was obtained through the principle of electroneutrality. As we consider only the presence of chloride anion in the extracellular environment, this concentration must be equal to the sum of the concentrations of all cations in the extracellular environment.…”

Section: Modeling and Theorymentioning

confidence: 99%

“… a From refs and . b From ref . c According to the principle of electroneutrality in an extracellular environment. …”

Section: Modeling and Theorymentioning

confidence: 99%

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Membrane Potential and Ion Partitioning in an Erythrocyte Using the Poisson–Boltzmann Equation

et al. 2015

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In virtually all mammal cells, we can observe a much higher concentration of potassium ions inside the cell and vice versa for sodium ions. Classical theories ignore the specific ion effects and the difference in the thermodynamic reference states between intracellular and extracellular environments. Usually, this differential ion partitioning across a cell membrane is attributed exclusively to the active ion transport. Our aim is to investigate how much the dispersion forces contribute to active ion pumps in an erythrocyte (red blood cell) as well as the correction of chemical potential reference states between intracellular and extracellular environments. The ionic partition and the membrane potential in an erythrocyte are analyzed by the modified Poisson-Boltzmann equation, considering nonelectrostatic interactions between ions and macromolecules. Results show that the nonelectrostatic potential calculated by Lifshitz theory has only a small influence with respect to the high concentration of K(+) in the intracellular environment in comparison with Na(+).

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Section: Modeling and Theorysupporting

confidence: 87%

Section: Modeling and Theorymentioning

confidence: 99%

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Membrane Potential and Ion Partitioning in an Erythrocyte Using the Poisson–Boltzmann Equation

et al. 2015

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“…In contrast, heavy drinking was related to a higher risk of IS [ 50 ]. Patients with hypertension have increased LDL-C levels [ 51 ] and normal or reduced levels of HDL-C [ 51 , 52 ]. It has been shown that statins can reduce blood pressure when they are taken for lipid-lowering therapy [ 53 ], indicating that hypertension is closely related to dyslipidaemia.…”

Section: Discussionmentioning

confidence: 99%

LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study

et al. 2020

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Background This study explored the relationships between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in patients with non-valvular atrial fibrillation (NVAF) in Xinjiang. The findings could provide a theoretical and therapeutic basis for NVAF patients. Methods NVAF patients who were admitted to 10 medical centres across Xinjiang were divided into stroke (798 patients) and control (2671 patients) groups according to the occurrence of first acute IS. Univariate and multivariate logistic regression analysis were used to examine the independent risk factors for IS in NVAF patients. Factor analysis and principal component regression analysis were used to analyse the main factors influencing IS. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminatory ability of LDL-C/HDL-C for predicting the occurrence of IS. Results The stroke group had an average age of 71.64 ± 9.96 years and included 305 females (38.22%). The control group had a mean age of 67.30 ± 12.01 years and included 825 females (30.89%). Multivariate logistic regression showed that the risk of IS in the highest LDL-C/HDL-C quartile (≥2.73) was 16.23-fold that of the lowest quartile (< 1.22); IS risk was 2.27-fold higher in obese patients than in normal-weight subjects; IS risk was 3.15-fold higher in smoking patients than in non-smoking patients. The area under the ROC curve of LDL-C/HDL-C was 0.76, the optimal critical value was 2.33, the sensitivity was 63.53%, and the specificity was 76.34%. Principal component regression analysis showed that LDL-C/HDL-C, age, smoking, drinking, LDL-C and hypertension were risk factors for IS in NVAF patients. Conclusions LDL-C/HDL-C > 1.22, smoking, BMI ≥24 kg/m2 and CHA2DS2-VASc score were independent risk factors for IS in NVAF patients; LDL-C/HDL-C was the main risk factor.

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Effect of Selenium on Selenoprotein Expression in the Adipose Tissue of Chickens

Yang

Lin

Wang

et al. 2014

Biol Trace Elem Res

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This study describes the effects of selenium (Se) deficiency on the messenger ribonucleic acid (mRNA) expression of 25 selenoproteins (Sels) (including glutathione peroxidases (GPx1-GPx4), thioredoxin reductases (TrxR1-TrxR3), iodothyronine deiodinases (ID1-ID3), selenophosphate synthetase 2 (SPS2), 15-kDa Sel (Sel15), SelH, SelI, SelK, SelM, Sepn1, SelO, Sepx, Selpb, SelS, SelT, SelW, Sepp1, and SelU in the adipose tissues (subcutaneous adipose, visceral adipose, and articular adipose) of chickens. One hundred and fifty 1-day-old chickens were randomly assigned to two groups of 75 each and were fed a low-Se diet (0.032 mg/kg Se) or a control diet (0.282 mg/kg Se). The expression levels of 25 Sel mRNAs were determined on days 35, 45, and 55 from three parts (subcutaneous adipose, visceral adipose, and articular adipose) of the chicken adipose tissues. The results showed that the expression levels of the 25 Sel mRNAs were significantly lower (P < 0.05) in the low-selenium group than in the control group. In addition, the Sel mRNA expression levels in the three adipose tissues were observed to decrease in a time-dependent manner with increasing feeding time.

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Clinical evaluation of lipids, lipoproteins and red blood cells sodium and potassium in patients with different grades of hypertension

Cited by 5 publications

References 49 publications

Membrane Potential and Ion Partitioning in an Erythrocyte Using the Poisson–Boltzmann Equation

Membrane Potential and Ion Partitioning in an Erythrocyte Using the Poisson–Boltzmann Equation

LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study

Effect of Selenium on Selenoprotein Expression in the Adipose Tissue of Chickens

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