Clinical evaluation of leukocyte filtration as an alternative anti-inflammatory strategy to aprotinin in high-risk patients undergoing coronary revascularization

Farsak, Bora; Günaydın, Serdar; Yildiz, Ülkü; Sarı, Tamer; Zorlutuna, Yaman

doi:10.1007/s00595-011-0012-9

Cited by 3 publications

(1 citation statement)

References 25 publications

(22 reference statements)

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“…These potentially adverse influences on a patient’s outcome could be minimized by using (for example) leucocyte filters, heparin coated circuits, or tubes coated with certain polymers [63]. A recently published study compared the beneficial effects of leucocyte depletion in combination with polymer-coated tubes and it was demonstrated that patients of this study arm compared to control patients had a significantly reduced risk of postoperative bleeding, atrial fibrillation, less need for catecholamine therapy, and a shorter period of mechanical ventilation [64]. Renal or neurological complications were slightly but not significantly reduced.…”

Section: Apparative Methods For Brain Protectionmentioning

confidence: 99%

Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass

Salameh

Dhein

Dähnert

et al. 2016

IJMS

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Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain.

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Section: Apparative Methods For Brain Protectionmentioning

confidence: 99%