Clinical evaluation of injectable platelet‐rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial

Türer, Onur Uçak; Özcan, Mustafa; Alkaya, Bahar; Surmeli, Seren; Şeydaoğlu, Gülşah; Haytaç, M. Cenk

doi:10.1111/jcpe.13193

Cited by 31 publications

(35 citation statements)

References 43 publications

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“…The combination has shown benefits, such as improved angiogenesis and handling ability by combining the small bone granules into a bulk material to use in bone grafting surgery [ 9 , 10 , 11 ]. Further use of i-PRF demonstrated that it was effective in regaining gingival thickness, reducing periodontal pocket depth, and attachment loss in periodontal tissue regeneration [ 12 , 13 ]. Although a few cases have reported an encouraging outcome, there has been a paradigm shift concerning the use of i-PRF in clinical bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation

Thanasrisuebwong

Kiattavorncharoen

Surarit

et al. 2020

IJMS

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The biological benefits of using two fractions derived from injectable platelet-rich fibrin (i-PRF) in bone regeneration remain unclear. Thus, the current study examined two fractionation protocols producing yellow i-PRF and red i-PRF on periodontal ligament stem cells (PDLSCs). The i-PRF samples from five donors were harvested from two different levels, with and without a buffy coat layer, to obtain red and yellow i-PRF, respectively. The PDLSCs were isolated and characterized before their experimental use. The culture medium in each assay was loaded with 20% of the conditioned medium containing the factors released from the red and yellow i-PRF. Cell proliferation and cell migration were determined with an MTT and trans-well assay, respectively. Osteogenic differentiation was investigated using alkaline phosphatase and Alizarin red staining. The efficiency of both i-PRFs was statistically compared. We found that the factors released from the red i-PRF had a greater effect on cell proliferation and cell migration. Moreover, the factors released from the yellow i-PRF stimulated PDLSC osteogenic differentiation earlier compared with the red i-PRF. These data suggest that the red i-PRF might be suitable for using in bone regeneration because it induced the mobilization and growth of bone regenerative cells without inducing premature mineralization.

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Section: Introductionmentioning

confidence: 99%

Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation

Thanasrisuebwong

Kiattavorncharoen

Surarit

et al. 2020

IJMS

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“…The observation of augmentation of WKG is in agreement with earlier reports. 24,25 It is known that the genetic information from the connective tissue will determine the character of surface epithelium. The biologic characteristics of PRF with the growth factors influencing tissue proliferation may to certain extent explain the above observations.…”

Section: Discussionmentioning

confidence: 99%

Platelet Rich Fibrin (PRF) along with Coronally Repositioned Flap (CRF) compared with that of CRF alone in the management of isolated Miller class-I gingival recession defects: A non-randomized controlled clinical trial

J¹,

Rm²,

Narayan³

2021

IJPI

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Background: Periodontal plastic surgical techniques for root coverage are aimed to attain optimal results with less patient discomfort. Platelet-rich fibrin (PRF) containing a wide array of growth factors within fibrin network has shown beneficial results in healing of tissues. Aims: Study evaluated clinical effects of PRF along with Coronally Repositioned Flap (CRF), test group, and compared it with CRF alone, control group, in the treatment of Miller Class I gingival recession. Setting and Design: From the subjects who attended the out-patients clinic, a non-randomized controlled clinical study was done on those who satisfied the inclusion criteria. Materials and Methods: In the control group 29 patients and in the test group 27 patients completed six months of study period. Clinical parameters pertaining to periodontal health and recession anatomy were recorded. Statistical Analysis: Student t-test was used for intra and inter-group comparison. Multiple linear regression model was developed using three predictor variables. Results: Mean root cover percentage in PRF and CRF groups were 96.25±6.89 and 94.59±10.31 respectively. PRF group showed reduction in gingival thickness at sixth month. Linear regression model showed a negative association of baseline gingival recession value with complete root coverage. Conclusion: CRF+PRF as well as CRF alone are equally effective in attaining >90% root coverage in Miller Class I gingival recession. The observed clinical benefits along with less invasive procedure involved in PRF technique, shows that it is a promising biomaterial in terms of objective appraisal. However, additional studies overcoming the limitations noticed are needed to ascertain the findings.

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“…The results also revealed that the first step in non-surgical approaches for enhancing and improving gingival thickness can be thought of as a combination of injectable platelet-rich fibrin and micro-needling [ 25 ]. Turer et al, in 2020, stated that gingival recession decreases more in group applied I-PRF in operations with coronally advanced flap with a connective tissue graft [ 26 ].…”

Section: Reviewmentioning

confidence: 99%

Injectable Platelet-Rich Fibrin - A Revolution in Periodontal Regeneration

Gollapudi¹,

Bajaj²,

Oza³

2022

Cureus

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As of a few years ago, platelet concentrates have been applied in a variety of medical and dental procedures. A notable aspect is that platelet-rich fibrin (PRF) is the most commonly utilized platelet concentrate in the field of dentistry. The most significant modification that was used over the years but had the biggest impact was injectable platelet-rich fibrin (I-PRF), which has more special properties. Additionally, the results of this I-PRF have been useful. The solid platelet-rich fibrin (PRF), which is a noticeable feature and has a low speed and duration in centrifugation, is the main advantage of I-PRF. I-PRF is primarily found in liquid form as PRF. It facilitates the quickening of increased vascularization and aids in accelerating the healing of wounds. An autologous blood concentration known as I-PRF has been known for many years.The advantage of I-PRF is that it exhibits constant release of growth factors and promotes cell migration by announcing the expression of type I collagen and transforming growth factor mRNA. The majority of the time, plastic and orthopedic operations use injectable platelet aggregates. It also reduces adverse reactions to transplanted material as compared to other grafting techniques. Additionally, it makes numerous other operations, like regenerative ones, much better options. In circumstances where it has been noticed, I-PRF is helpful and crucial in periodontics for bone regeneration and wound healing. It is therefore not difficult to predict that this fully autologous blood concentrate, which is now being utilized in numerous applications and requires little invasiveness, will become even more frequently used in the future. This review paper contains the differences between platelet-rich plasma (PRP) and PRF, the development of diverse platelets, and the use of I-PRF in periodontal therapy.

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Clinical evaluation of injectable platelet‐rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial

Cited by 31 publications

References 43 publications

Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation

Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation

Platelet Rich Fibrin (PRF) along with Coronally Repositioned Flap (CRF) compared with that of CRF alone in the management of isolated Miller class-I gingival recession defects: A non-randomized controlled clinical trial

Injectable Platelet-Rich Fibrin - A Revolution in Periodontal Regeneration

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