Clinical evaluation of efficacy of triamcinolone acetonide with tacrolimus in the management of oral lichen planus: A pilot prospective observational study

Walia, Cheshta; Rallan, Mandeep; Premkumar, Anu; Roy, Sudip

doi:10.4103/ccd.ccd_899_20

Cited by 3 publications

(2 citation statements)

References 26 publications

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“… Skin thinning 27 Triamcinolone acetonide Prevent erythema and ulceration. Inflammation of hair follicles 28 Fluocinonide Prevents itching, burning, and discomfort. Loss of skin pigmentation 29 Betamethasone Anti-inflammatory and immunosuppressive to OLP.…”

Section: Methodsmentioning

confidence: 99%

Impact of exosomes in oral lichen planus: A review with insights into pathogenesis and biomarkers

Ram Kumar,

Joghee,

Puttaraju

2024

Journal of Dental Sciences

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Section: Methodsmentioning

confidence: 99%

Impact of exosomes in oral lichen planus: A review with insights into pathogenesis and biomarkers

Ram Kumar,

Joghee,

Puttaraju

2024

Journal of Dental Sciences

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“…18 Topical corticosteroids are also commonly prescribed in dentistry as triamcinolone which is used for achieving relief from symptoms of mouth sores due to injury and autoimmune lesions as oral lichen planus, oral candidiasis was the most frequently reported oral side effect, with swelling, bruising or discoloration, slow wound healing and itching all being observed less commonly. 19 Prednisolone and Prednisone are also commonly used as a systemic medication for the treatment of severe allergies, inflammatory and auto-immune conditions, and their use was associated with increased risk of infections; additionally, ulcerations; particularly with the adjunct use of an NSAID is another common finding. Bone thinning, bruising and slower wound healing can also be seen less commonly.…”

Section: Steroidalmentioning

confidence: 99%

Side Effects of Steroidal and Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity.

Ghazi,

Rasul,

Hamad

et al. 2024

EDJ

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Background and objectives: The steroidal and Non-Steroidal Anti-Inflammatory drugs (NSAIDs) are widely used classes of medications for their anti-inflammatory and analgesic effects and are associated with the risk of many oral side effects and which might be presented with variable degrees of severity. The main objective of this research was to identify oral side effects that could be associated with using Steroidal or NSAIDs. Patients and Methods: A total number of 82 patients who were attending the teaching clinics at the College of Dentistry and were using steroids or NSAIDs participated in this study and they were interviewed and examined clinically for the presence of any abnormal oral presentation. The data were all recorded on a pre-designed questionnaire. The data was expressed as a percentage and analyzed statistically using ANOVA and t-test. Results: The data showed that a majority of NSAIDs users complained of gingival bleeding (39%) and Xerostomia (32%), while corticosteroid users complained of fungal infection (50%), gingival inflammation (25%) and other less frequent side effects. Drugs that were associated with the most oral side effects were aspirin, ibuprofen, mefenamic acid and prednisolone. Conclusion: Data analysis showed that many oral side effects might be related to steroidal and NSAIDs. It is important to consider that drugs in general may cause oral side effects at different doses, dosage forms and durations of use and may have a variety of clinical presentation. The dentists have a crucial role in identifying these drug-related oral side effects through their clinical practices in order to provide the proper management for the patients. Keywords: Side effects, steroids, NSAIDs, xerostomia, Ulcers.

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Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

Saeed

Choudhury²,

Ahmad

et al. 2022

Biomedicines

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Oral lichen planus (OLP) is a chronic mucocutaneous condition that affects up to 2% of the general population, and typically presents with long-standing, non-responsive lesions, with episodes of exacerbation and remissions. The etiopathogenesis of OLP is still unclear, although, it has been postulated that it is most likely a T-cell-mediated condition of an unknown antigen. The treatment remains a challenge with no defined treatment strategy. Vitamin D has anti-inflammatory and immunomodulatory properties, along with its regulatory effect on keratinocyte proliferation and differentiation; thus, suggesting its possible role in the treatment of OLP. This systematic review aims to evaluate the therapeutic role of vitamin D in OLP treatment. We searched PubMed/MEDLINE, and Google scholar search engines for studies evaluating vitamin D as a treatment modality in OLP from January 2000 to August 2022. Articles were searched with the combination of Medical Subject Heading (MeSH) terms. A web platform for visualizing risk-of-bias assessment was used in this review, and descriptive statistics were calculated. Out of the seventeen retrieved studies, five articles meeting the inclusion criteria were considered in this systematic review. All the included studies demonstrated significant amelioration in the OLP symptoms in patients who were given vitamin D supplements as an adjuvant to the conventional steroid therapy and or placebo. This systematic review signifies the role of vitamin D as adjuvant therapy for OLP. However, more studies with larger sample size are required to validate these results.

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Clinical evaluation of efficacy of triamcinolone acetonide with tacrolimus in the management of oral lichen planus: A pilot prospective observational study

Cited by 3 publications

References 26 publications

Impact of exosomes in oral lichen planus: A review with insights into pathogenesis and biomarkers

Impact of exosomes in oral lichen planus: A review with insights into pathogenesis and biomarkers

Side Effects of Steroidal and Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity.

Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review

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