Clinical evaluation of dexmedetomidine on haemodynamic stress response during laryngoscopy and intubation: A randomized double blind parallel group placebo controlled study

Shah, Komal S; Bhut, Chandrika; Gaukr, Naveen

doi:10.18231/2394-4994.2019.0004

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…After laryngoscopy, blood pressure and heart rate will start to rise within 5 seconds and peak after 30-45 seconds. These alterations are usually temporary and well tolerated by healthy people, but they can be disastrous in people with high blood pressure, coronary artery disease, or cerebrovascular illness and may trigger pulmonary edema, acute left ventricular failure, intraoperative myocardial infarction (6) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Remifentanil Bolus vs Fentanyl in Attenuating Hemodynamic Response in Videolaryngoscopic Endotracheal Intubation

Jalal,

Khudadad

2023

JSMC

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Background Elevation of blood pressure and pulse rate are hemodynamic changes that occur during general anesthesia as a consequence of laryngoscopy and endotracheal intubation ETI, different laryngoscopies and many drugs have been tried to reduce these changes. Objectives To evaluate and compare the efficacy of minimum dose of fentanyl and comparable remifentanil bolus dose during videolaryngoscopic ETI. Patients and MethodsA triple blind randomized clinical trial implemented on 224 patients of age group between 16-65 years of either sex (ASA I and ASA II) scheduled for elective operation under general anesthesia with endotracheal intubation, they are randomly assigned into two groups, group A and group B representing both fentanyl and remifentanil as the drug preparation was unknown neither by the patient nor by the researcher and nor by the data analyser, in addition propofol two mg/kg and rocuronium 0.8 mg/kg were given then systolic blood pressure SBP, diastolic blood pressure DBP, mean arterial blood pressure MAP and heart rate HR were recorded in five different occasions as (T0) for baseline preinduction, (T1) one minute before ETI, (T2) one minute after ETI, (T3) three minutes after ETI and (T4) five minutes after ETI. ResultsThere was a significant difference in the mean value of HR, SBP, DBP, MAP in both groups before, one, three and five minutes after endotracheal intubation with King vision videolaryngoscope KVVL and one μg/kg remifentanil bolus administration (group B) effectively showed substantial reduction in all hemodynamic parameters with significant statistical result (P < 0.05) when compared to intravenous IV fentanyl one μg/kg (group A). ConclusionRemifentanil bolus of one μg/kg is better than intravenous fentanyl one μg/kg in attenuating hemodynamic response to ETI when KVVL used.

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Section: Introductionmentioning

confidence: 99%