Clinical Evaluation of Demineralized Freeze‐Dried Bone Allograft With and Without Enamel Matrix Derivative for the Treatment of Periodontal Osseous Defects in Humans

Hoidal, Matt J.; Grimard, Brently A.; Mills, Michael P.; Schoolfield, John; Mellonig, James T.; Mealey, Brian L.

doi:10.1902/jop.2008.080259

Cited by 45 publications

(59 citation statements)

References 34 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conventional open‐flap debridement (OFD) falls short of regenerating tissues destroyed by the disease, and current regenerative procedures offer a limited potential toward attaining a complete periodontal restoration 3 . Various biomaterials 4‐10 based on endogenous regenerative technology (ERT) have been used for periodontal tissue regeneration in addition to autogenous 11,12 and allogenic bone grafts, 13,14 but there is not a single graft material that is considered a gold standard in the treatment of intrabony defects (IBDs).…”

mentioning

confidence: 99%

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Sharma

Pradeep

2011

Journal of Periodontology

173

168

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Sharma

Pradeep

2011

Journal of Periodontology

173

168

View full text Add to dashboard Cite

show abstract

“…Flap collapse may subsequently lead to limitation of the space available for regeneration, thus limiting clinical outcomes 28,29 . To overcome this potential drawback and improve the clinical results obtained with EMD, recent attempts at combining DFDBA with EMD have been investigated 14,16,18,30‐32 . Whereas a small number of clinical and animal studies reveals a potential benefit for their combination, 14,18,31,32 others have failed to demonstrate an advantage 16,30 …”

mentioning

confidence: 99%

In Vitro Evaluation of Demineralized Freeze‐Dried Bone Allograft in Combination With Enamel Matrix Derivative

Miron

Bosshardt

Laugisch

et al. 2013

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…Two studies [10,12] were included to assess the effectiveness of EMD when used along with DFDBA and were compared to use of DFDBA alone. One study by Aspriello et al with parallel design of randomized controlled clinical trial with 12 month follow-up was included for evaluating the effectiveness on EMD with DFDBA.…”

Section: Discussionmentioning

confidence: 99%

Efetividade da utilização de enxertos ósseos desmineralizados liofilizados no tratamento de defeitos intraósseos – uma revisão sistemática

Parthasarathy

Jayakumar²,

Sankari³

et al. 2016

Rev. Odonto Ciênc. (Online)

View full text Add to dashboard Cite

Objective: To systematically evaluate the effect of adjuncts with demineralized freeze dried bone in the treatment of intrabony defects in terms of clinical and radiological outcomes. Methods: A search was conducted for randomized controlled trials in cases of chronic periodontitis to evaluate the effect of adjuncts with demineralized freeze dried bone in the treatment of intrabony defects. The electronic databases like PUBMED and the Cochrane Central Register of Controlled Trials were used as data sources. Gain in clinical attachment level was considered as the primary outcome variable while Pocket depth reduction and Radiological bone fill were considered to be the secondary outcome variables. Results: Of all the articles screened, seven controlled human clinical trials met the eligibility criteria and provided clinical and radiological outcome data on the effectiveness of adjuncts with Demineralized Freeze Dried Bone Allograft (DFDBA) in the treatment of intrabony defects. Amongst the above mentioned seven trials, three controlled clinical trial showed significant results while four controlled clinical trials did not show significant results. From this systematic review, it can be concluded that the treatment with Autologous Platelet Concentrate (PRP) in combined with DFDBA showed significant results in probing pocket depth reduction and clinical attachment level gain. Cyclosporine A in combination with DFDBA showed significant radiological bone fill and Enamel Matrix Derivative (EMD) in combination with DFDBA with 12 months followup showed significant soft tissue and hard tissue healing. Conclusion: PRP in combination with DFDBA showed significant results in probing pocket depth reduction and clinical attachment level gain. Cyclosporine with DFDBA showed significant radiological bone fill and EMD in combination to DFDBA with 12 months follow-up showed significant soft tissue and hard tissue healing. However, long term studies are needed to clarify the effectiveness of adjuncts with DFDBA in the treatment of intrabony defect.Key words: Demineralized freeze dried bone allograft; Chronic periodontitis; Intrabony defect; Guided tissue regeneration; Antimicrobials; Immunosuppressive agents; Autologous platelet concentrate and Enamel matrix derivative Efetividade da utilização de enxertos ósseos desmineralizados liofilizados no tratamento de defeitos intraósseos -uma revisão sistemática Resumo Objetivo: Avaliar de forma sistemática o efeito da utilização de enxertos ósseos desmineralizados liofilizados, com adjuvante, no tratamento de defeitos intraósseos, com desfechos clínicos e radiográficos. Métodos: Foi realizada uma busca por ensaios controlados e randomizados em casos de periodontite crônica para avaliar os efeitos da utilização de enxertos ósseos desmineralizados liofilizados como adjuntos no tratamento de defeitos ósseos. Para tal, foram utilizadas as bases de dados PUBMED e COCHRANE. O ganho nos níveis de inserção clínica foi considerado como a variável primária no desfecho, enquanto a redução da...

show abstract

Clinical Evaluation of Demineralized Freeze‐Dried Bone Allograft With and Without Enamel Matrix Derivative for the Treatment of Periodontal Osseous Defects in Humans

Abstract: Both treatments were shown to be safe and effective therapy for periodontal defects; however, the addition of EMD to DFDBA provided no statistically significant improvement to the soft and hard tissue parameters measured.

Cited by 45 publications

References 34 publications

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

Treatment of 3‐Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet‐Rich Fibrin: A Randomized Controlled Clinical Trial

In Vitro Evaluation of Demineralized Freeze‐Dried Bone Allograft in Combination With Enamel Matrix Derivative

Efetividade da utilização de enxertos ósseos desmineralizados liofilizados no tratamento de defeitos intraósseos – uma revisão sistemática

Contact Info

Product

Resources

About