Clinical Evaluation of Calcium Metabolism in Adult T-Cell Leukemia/Lymphoma

Fukumoto, Seiji; Matsumoto, Toshio; Ikeda, Kyoji; Yamashita, Takayuki; Watanabe, Toshiki; Yamaguchi, Kazunari; Kiyokawa, Tetsuyuki; Takatsuki, Kiyoshi; Shibuya, Naohiko; Ogata, Etsuro

doi:10.1001/archinte.1988.00380040161023

Cited by 80 publications

(16 citation statements)

References 26 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,12,13 Several cytokines, such as interleukin-1 (IL-1), 14 transforming growth factor ␤, 15 and parathyroid hormone-related protein (PTH-rP) 16 have been implicated in ATL-associated hypercalcemia. Among these factors, PTH-rP is considered to play an important role by stimulating OCLs, resulting in increased bone resorption.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor κB ligand on adult T-cell leukemia cells

Nosaka

Miyamoto

Sakai

et al. 2002

Blood

155

118

View full text Add to dashboard Cite

Hypercalcemia is one of the most frequent and serious complications in patients with adult T-cell leukemia (ATL) and is due to marked bone resorption by accumulation of osteoclasts (OCLs). Although several cytokines such as interleukin 1 and parathyroid hormone-related protein are thought to be involved in the development of high serum Ca ؉؉ levels, its precise underlying mechanism remains unknown. This study analyzed the expression of various genes that are thought to regulate serum Ca ؉؉ levels in ATL and showed that the overexpression of the receptor activator of nuclear factor

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor κB ligand on adult T-cell leukemia cells

Nosaka

Miyamoto

Sakai

et al. 2002

Blood

155

118

View full text Add to dashboard Cite

show abstract

“…The present case involved ATLwith severe hypercalcemia, complicated by respiratory insufficiency due to metastatic calcification in the lungs. Hypercalcemia has been reported to be a commoncomplication ofATL, with an incidence of40% to 70% (10)(11)(12)(13)(14)(15)20). At autopsy, proliferation of osteoclasts with extensive bone resorption has been observed in cases with ATL(21).…”

Section: Discussionmentioning

confidence: 99%

“…At autopsy, proliferation of osteoclasts with extensive bone resorption has been observed in cases with ATL(21). This hypercalcemia was closely associated with elevated nephrogenous cyclic adenosine monophosphate and reduced serum 1, 25-dihydroxyvitamin D3 concentration with a low to normal immunoreactive PTH level (20). The humoral factor, PTHrP produced by tumor cells in ATL, is believed to play an important role in the development of hypercalcemia by stimulating osteoclastic bone resorption (9,15,18,(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Adult T-cell Leukemia with Hypercalcemia-induced Metastatic Calcification in the Lungs Due to Production of Parathyroid Hormone-related Protein.

et al. 2001

View full text Add to dashboard Cite

A 60-year-old manwas diagnosed as adult T-cell leukemia with severe hypercalcemia because of production of parathyroid hormone-related protein. After admission, the patient had respiratory insufficiency with an infiltrative shadow in his lungs suggestive of pneumonia. However, neither improvement in respiratory function nor disappearance of the abnormal chest shadowwas observed with administration of various antibiotics. Anautopsy demonstrated the chest shadow had been caused by metastatic calcification associated with hypercalcemia due to production of parathyroid hormone-related protein. The possibility of metastatic calcification should be considered in patients with adult T-cell leukemia and hypercalcemia who have an abnormal chest shadow. (Internal Medicine 40: 409-413, 2001)

show abstract

“…56 Patients present with typical symptoms of hypercalcemia, such as lethargy, constipation, confusion, dehydration, and polyuria.37 54-5' The hypercalcemia may be unresponsive to treatment with standard measures until chemotherapy for ATLL is instituted. Not infrequently, hypercalcemia is associated with the terminal phase of the disease and may be a cause ofearly death.…”

Section: Special Complicationsmentioning

confidence: 99%

Adult T Cell Leukemia/Lymphoma

2016

The Cutaneous Lymphoid Proliferations

View full text Add to dashboard Cite

Clinical Evaluation of Calcium Metabolism in Adult T-Cell Leukemia/Lymphoma

Cited by 80 publications

References 26 publications

Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor κB ligand on adult T-cell leukemia cells

Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor κB ligand on adult T-cell leukemia cells

Adult T-cell Leukemia with Hypercalcemia-induced Metastatic Calcification in the Lungs Due to Production of Parathyroid Hormone-related Protein.

Adult T Cell Leukemia/Lymphoma

Contact Info

Product

Resources

About