Clinical Evaluation of an Intraoral Device for the Controlled Release of Fluoride

Mirth, Dale B.; Shern, R.J.; Emilson, Claes‐Göran; Adderly, Donna D.; Li, Shou-Hua; Gomez, Irma; Bowen, William H.

doi:10.14219/jada.archive.1982.0481

Cited by 60 publications

(58 citation statements)

References 30 publications

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“…The direct comparison of the finding of this research is with the studies of Mirth et al 13,14 who showed that the use of an F containing co-polymer membrane device could release F and inhibit dental caries. However, the SFG described herein, produced a significant rise in saliva F concentrations for over 18 months.…”

Section: Discussionsupporting

confidence: 70%

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In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

Curzon

Toumba

2004

Br Dent J

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AimsThe aims were to evaluate a) whether a slow release fluorideglass pellet (SFG) would be retained in the mouth and release fluoride (F) over a long period of time, b) what concentrations of F in the glass would provide ideal intra-oral saliva F concentrations and c) whether an SFG would affect blood plasma concentrations of F after swallowing compared with ingestion of a commercial NaF tablet. Methods a) A prototype SFG was attached to a maxillary molar of a volunteer. Baseline saliva F concentrations were measured prior to glass placement, daily in week one; one day a week for weeks two to three and then one day a month up to18 months. Four subjects had the SFG for six months with saliva F concentration assessments at periodic intervals. b) SFGs containing F at 13.3%, 18.3% and 21.9%, and an improved solubility, were tested using three volunteers and saliva F concentrations measured. c) Five volunteers each swallowed either a SFG or a NaF tablet. Blood plasma samples were taken at baseline and F measured at time intervals of 2. 5,5,10,20, 30, 45, 60, 90 and 120 mins post-ingestion. Results a) The prototype SFG were successfully retained and released F into saliva; mean concentrations of 0.035 mg L -1 were achieved lasting for over 18 months.

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Section: Discussionsupporting

confidence: 70%

“…Intraoral devices, such as in the form of co-polymer membranes, retained on the teeth, have more recently been shown to be effective. Raised intra-oral F salivary concentrations have been achieved in humans 13 and animals. 14 In humans the salivary F concentrations have been associated with a reduction in new carious lesions.…”

Section: N B R I E Fmentioning

confidence: 99%

In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

Curzon

Toumba

2004

Br Dent J

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“…Available evidence shows clearly that the cariostatic effect of fluoride is heavily dependent on its ambient levels in the mouth (Larson and Mellberg, 1977;Mirth et al , 1982Mirth et al , , 1983Corpron et al , 1986). These observations suggest that low levels of fluoride constantly present in the mouth are critical for the expression of its maximum effect (Duckworth et al , 1987;Meyerowitz and Watson, 1998).…”

Section: Enhancing the Effects Of Fluoridementioning

confidence: 99%

Do We Need to be Concerned about Dental Caries in the Coming Millennium?

Bowen

2002

Critical Reviews in Oral Biology & Medicine

Self Cite

201

109

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ABSTRACT:Dental caries continues to be a pubic health problem despite claims that 50% of schoolchildren are caries-free. There are widespread variations in the prevalence of caries worldwide. Caries lesions are the clinical manifestation of a pathogenic process that may have been occurring on the tooth surface for months or years. Acid production by bacteria embedded in a biofilm termed "dental plaque" is a key aspect of the pathogenesis of dental caries; nevertheless, the ability of micro-organisms to survive in a hostile acid milieu and the influence of fluoride and additional agents on this acid tolerance receive scant attention. Study of cariogenic micro-organisms largely has been limited to observations made on them in the planktonic state; clearly dental caries is essentially a surface phenomenon, and micro-organisms behave distinctively when grown on a surface. Although significant progress has been made in our understanding of the etiology, pathogenesis, and prevention of dental caries, it still remains a scientific and clinical enigma worthy of the attention of the best scientists.

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“…A suggested protocol involves the daily application of neu tral sodium fluoride gel (5,000 ppm) in vacuform custom carriers, 43 or the use of intraoral fl uoride-releasing systems. [44][45][46] Periodontal, conservative and endodontic treatment Mandibular hypomobility will quite often limit the length of time treat ment can be undertaken for a patient in a session; frequent breaks, moments of aspirator; however, use of smaller diam eter or additional saliva ejectors or aspi rators may be more appropriate. If the mandibular hypomobility is severe, it may not be possible to use suction at all, and treatment will need to be stopped and the patient instructed to expecto rate/rinse.…”

Section: Prevention Self-care and Oral Hygienementioning

confidence: 99%

Management of patients with reduced oral aperture and mandibular hypomobility (trismus) and implications for operative dentistry

2008

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Clinical Evaluation of an Intraoral Device for the Controlled Release of Fluoride

Cited by 60 publications

References 30 publications

In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

In vitro and in vivo assessment of a glass slow fluoride releasing device: a pilot study

Do We Need to be Concerned about Dental Caries in the Coming Millennium?

Management of patients with reduced oral aperture and mandibular hypomobility (trismus) and implications for operative dentistry

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