Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye

Christensen, Mike; Cohen, Steven B.; Rinehart, John J.; Akers, Frank; Pemberton, Bart; Bloomenstein, Marc R.; Lesher, Mark P.; Kaplan, David J.; Meadows, David; Meuse, Patricia; Hearn, Charles; Stein, Jerry

doi:10.1076/ceyr.28.1.55.23495

Cited by 97 publications

(121 citation statements)

References 10 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…This approach attempts to coat the ocular surface and integrate the artificial tear with the existing tear film to provide protection. This protection may be enhanced with new technologies that provide longer retention times for the tear substitutes on the ocular surface [34]. An effective artificial tear should provide an environment in which the damaged corneal epithelium can be repaired and recover its normal function.…”

Section: Discussionmentioning

confidence: 99%

“…It also provides an effective mucomimetic artificial tear product [35]. Systane, the first eye drop to incorporate HPG, designed to develop into a soft gel when placed on the eye allows cell repair in an ocular surface microenvironment [34, 35]. Systane contains the active ingredients PEG and PG.…”

Section: Discussionmentioning

confidence: 99%

“…There are several studies that report improvement with the use of HPG on the ocular surface in patients with dry eye disease. In a study by Christensen et al [34], 87 patients were randomized to receive PG-HPG or 0.5% carboxymethyl cellulose (CMC) for 6 weeks. The results of this study suggested that PG-HPG provided superior relief of dry eye signs and symptoms compared to 0.5% CMC.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Lubricating Eye Drop Containing Hydroxypropyl Guar on Perimetry Results of Patients with Glaucoma and Trachomatous Dry Eye

Güzey¹,

Satici²,

Karaman³

et al. 2009

Ophthalmologica

View full text Add to dashboard Cite

Purpose: To evaluate the effects of a mid-viscosity mucomimetic lubricant eye drop containing hydroxypropyl guar (HPG) as a gelling agent on computerized perimetry FASTPAC test results of primary open-angle glaucoma (POAG) patients with trachomatous dry eye. Methods: Both eyes of 33 patients with bilateral POAG and trachomatous dry eye were included in the study. They were treated with the same antiglaucomatous eye drop and underwent computerized perimetry. Before and after the treatment with lubricant eye drop (Systane™) for 8 weeks, tear function tests (Schirmer test with topical anesthesia, fluorescein staining and tear film break-up time) and FASTPAC test with computerized perimetry were performed. Pre- and posttreatment tear functions, visual field test global indices, reliability indices, test duration and numbers of depressed points in pattern deviation plots were compared. Results: We found significant improvements in tear function tests results, in computerized perimetry FASTPAC test indices, test duration and the number of depressed points in pattern deviation plots in the posttreatment evaluations. Conclusion: This study indicates that there was a benefit of mid-viscosity lubricant eye drop containing HPG treatment on computerized perimetry FASTPAC test performance in POAG subjects with trachomatous dry eye. We assume that the positive effect of this therapy is probably due to a better tear film stability, resulting in a higher optical quality of the repaired anterior corneal surface.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Lubricating Eye Drop Containing Hydroxypropyl Guar on Perimetry Results of Patients with Glaucoma and Trachomatous Dry Eye

Güzey¹,

Satici²,

Karaman³

et al. 2009

Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…Esto es debido a que la fluorofotometría es la única técnica objetiva para valorar la función barrera del epitelio corneal. La fluorofotometría ha sido empleada para el estudio de la permeabilidad del epitelio en múltiples circunstancias: autofluorescencia (17,18), en usuarios de lentes de contacto (19)(20)(21), en tratamientos tópicos con y sin conservantes (22)(23)(24)(25)(26)(27)(28)(29), después de un tratamiento quirúrgico, en pacientes con ojo seco de diversa etiología (30,31), en patologías sistémicas (32-35) y para estudios de fisiología corneal (36)(37)(38)(39)(40)(41). En un trabajo nuestro anterior observamos que el valor de permeabilidad epitelial corneal en sujetos normales es 34,4±23,5 ng/ml (27).…”

Section: Discussionunclassified

“…El HP-Guar presenta actividad mucomimética, protege el epitelio corneal a largo plazo y favorece además su función de barrera al facilitar la regeneración epitelial (9,40). Este principio esta acompañado de los demulcentes polietilenglicol 400 (PEG 400) y propilenglicol, y hay que considerar el conjunto de los 3 como el «principio activo» del producto.…”

Section: Discussionunclassified

Reducción de la permeabilidad corneal en pacientes tratados con HP-Guar: estudio fluorofotométrico

Sáenz-Francés-San-Baldomero

Benítez-del-Castillo

et al. 2006

Arch Soc Esp Oftalmol

View full text Add to dashboard Cite

Over the counter (OTC) artificial tear drops for dry eye syndrome

Pucker

Marrone

Nichols

2012

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Background-Over the counter (OTC) artificial tears historically have been the first line of treatment for dry eye syndrome and dry eye-related conditions like contact lens discomfort, yet currently we know little regarding the overall efficacy of individual, commercially available artificial tears. This review provides a much needed meta-analytical look at all randomized and quasi-randomized clinical trials that have analyzed head-to-head comparisons of OTC artificial tears.Objectives-To evaluate the effectiveness and toxicity of OTC artificial tear applications in the treatment of dry eye syndrome compared with another class of OTC artificial tears, no treatment, or placebo. Search methods-We searched CENTRAL (which contains the Cochrane Eyes and VisionTrials Register) (2015, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE and the US Food and Drugs Administration (FDA) website (www.fda.gov). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 4 December 2015. We searched reference lists of included trials for any additional trials not identified by the electronic searches.Selection criteria-This review includes randomized controlled trials with adult participants who were diagnosed with dry eye, regardless of race and gender. We included trials in which the age of participants was not reported, and clinical trials comparing OTC artificial tears with another class of OTC artificial tears, placebo, or no treatment. This review did not consider head-to-head comparisons of artificial tears with another type of dry-eye therapy.Data collection and analysis-We followed the standard methodological procedures expected by Cochrane. Two authors independently screened the search results, reviewed full-text copies for eligibility, examined risk of bias, and extracted data. We performed meta-analysis for trials that compared similar interventions and reported comparable outcomes with sufficient data. We summarized all other included trial results in the text.Main results-We included 43 randomized controlled trials (3497 participants with dry eye). Due to the heterogeneity of study characteristics among the included trials with respect to types of diagnostic criteria, interventions, comparisons, and measurements taken, our ability to perform meta-analyses was limited. The review found that, in general, there was uncertainty whether different OTC artificial tears provide similar relief of signs and symptoms when compared with each other or placebo. Nevertheless, we found that 0.2% polyacrylic acid-based artificial tears were consistently more effective at treating dry eye symptoms than 1.4% polyvinyl alcohol-based artificial tears in two trials assessing this comparison (175 participants). All other included artificial tears produced contradictory between-group results or found no between-group differences. Our review also found that OTC artificial tears may be generally safe, bu...

show abstract

Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye

Abstract: The Test Product was more effective at reducing both the signs and symptoms of dry eye compared to the carboxymethylcellulose containing Control.

Cited by 97 publications

References 10 publications

The Effect of Lubricating Eye Drop Containing Hydroxypropyl Guar on Perimetry Results of Patients with Glaucoma and Trachomatous Dry Eye

The Effect of Lubricating Eye Drop Containing Hydroxypropyl Guar on Perimetry Results of Patients with Glaucoma and Trachomatous Dry Eye

Reducción de la permeabilidad corneal en pacientes tratados con HP-Guar: estudio fluorofotométrico

Over the counter (OTC) artificial tear drops for dry eye syndrome

Contact Info

Product

Resources

About