Clinical evaluation of a portable lactate meter in type I glycogen storage disease

Saunders, A.; Feldman, Henry A.; Correia, Catherine E.; Weinstein, David A.

doi:10.1007/s10545-005-0090-1

Cited by 42 publications

(24 citation statements)

References 12 publications

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“…8 There were no restrictions on tourniquet use. Research assistants placed 5 lL of blood on the meter's test strip, ran the meter, and recorded the result on a data collection form placed in a locked box.…”

Section: Methodsmentioning

confidence: 99%

The Utility of Early Lactate Testing in Undifferentiated Pediatric Systemic Inflammatory Response Syndrome

Scott

Donoghue

Gaieski

et al. 2012

Academic Emergency Medicine

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Objectives: Failure to recognize shock contributes to inadequate early resuscitation in many children with sepsis. Serum lactate levels are used to identify adult patients with septic shock, but physical examination diagnosis alone is recommended in pediatric sepsis. The authors sought to test the utility of lactate testing in pediatric emergency department (ED) patients with systemic inflammatory response syndrome (SIRS). The hypothesis was that early hyperlactatemia (serum lactate 4.0 mmol/L) would be associated with increased risk of organ dysfunction.Methods: This was a prospective cohort study of children younger than 19 years with SIRS presenting to a pediatric ED. The primary outcome was organ dysfunction within 24 hours of triage; secondary outcomes included disposition, serious bacterial infection (SBI), treatments, and mortality. Study personnel measured venous lactate level on a point-of-care meter, with clinicians blinded to results, and patients received usual care.Results: A total of 239 subjects were enrolled; 18 had hyperlactatemia. The hyperlactatemia group had a relative risk of 5.5 (95% confidence interval [CI] = 1.9 to 16.0) of developing 24-hour organ dysfunction. As a test for organ dysfunction, hyperlactatemia had a positive likelihood ratio of 5.0, a sensitivity of 31% (95% CI = 13% to 58%), and specificity of 94% (95% CI = 90% to 96%). Subjects with hyperlactatemia were significantly more likely to receive intravenous (IV) antibiotics and fluid boluses; despite increased therapy, they were at significantly increased risk for intensive care unit (ICU) admission and bacterial infection.Conclusions: Among undifferentiated children with SIRS, early hyperlactatemia is significantly associated with increased risk of organ dysfunction, resuscitative therapies, and critical illness. The addition of serum lactate testing to the currently recommended clinical assessment may improve early identification of pediatric sepsis requiring resuscitation.

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Section: Methodsmentioning

confidence: 99%

The Utility of Early Lactate Testing in Undifferentiated Pediatric Systemic Inflammatory Response Syndrome

Scott

Donoghue

Gaieski

et al. 2012

Academic Emergency Medicine

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“…The lactate meter has been found more useful in GSD Ia as compared with GSD Ib in one study. 102 Continuous blood glucose monitoring system. Another tool that is often considered for monitoring and managing BG control in GSD is the continuous glucose monitoring system.…”

Section: Genetics In Medicinementioning

confidence: 99%

Diagnosis and management of glycogen storage disease type I: a practice guideline of the American College of Medical Genetics and Genomics

Kishnani

Austin

Abdenur

et al. 2014

Genetics in Medicine

359

554

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“…Three minutes after the end of each exercise set, a fingertip blood sample (5 l) was collected, and blood lactate concentration ([La] b) was determined (Lactate Pro; Arkray, Kyoto, Japan) (44). The accuracy of the analyzer was checked before each test using standards.…”

Section: Experimental Designmentioning

confidence: 99%

Parasympathetic reactivation after repeated sprint exercise

Buchheit

Laursen²,

Ahmaidi³

2007

American Journal of Physiology-Heart and Circulatory Physiology

233

301

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Buchheit M, Laursen PB, Ahmaidi S. Parasympathetic reactivation after repeated sprint exercise. Am J Physiol Heart Circ Physiol 293: H133-H141, 2007. First published March 2, 2007; doi:10.1152/ajpheart.00062.2007.-The purpose of this study was to examine the effects of muscular power engagement, anaerobic participation, aerobic power level, and energy expenditure on postexercise parasympathetic reactivation. We compared the response of heart rate (HR) after repeated sprinting with that of exercise sessions of comparable net energy expenditure and anaerobic energy contribution. Fifteen moderately trained athletes performed 1) 18 maximal all-out 15-m sprints interspersed with 17 s of passive recovery (RS), 2) a moderate isocaloric continuous exercise session (MC) at a level of mean oxygen uptake similar to that of the RS trial, and 3) a high-intensity intermittent exercise session (HI) conducted at a level of anaerobic energy expenditure similar to that of the RS trial. Subjects were immediately seated after the exercise trials, and beatto-beat HR was recorded for 10 min. Parasympathetic reactivation was evaluated through 1) immediate postexercise HR recovery, 2) the time course of the root mean square for the successive R-R interval difference between successive 30-s segments (RMSSD30s) and 3) HR variability vagal-related indexes calculated for the last 5-min stationary period of recovery. RMSSD30s increased during the 10-min period after the MC trial, whereas RMSSD 30s remained depressed after both the RS and HI trials. Parasympathetic reactivation indexes were similar for the RS and HI trials but lower than for the MC trial (P Ͻ 0.001). When data of the three exercise trials were considered together, only anaerobic contribution was related to HR trial-derived indexes. Parasympathetic reactivation is highly impaired after RS exercise and appears to be mainly related to anaerobic process participation.heart rate recovery; vagal-related indexes; autonomic activity; sprint interval training REPEATED SPRINT (RS) training, characterized by recurring sessions of brief repeated bouts of supramaximal exercise, may be a time-efficient strategy for inducing metabolic adaptations in human skeletal muscle (15). Adaptations shown after a short time course of RS training include increased resting glycogen content (20), increased maximal activities of various enzymes involved in glycolytic (31) and oxidative energy provision (10,20), an increased H ϩ buffer capacity (17,20), and decreased cycling time-trial performance (10,15,20). As a result, RS training has been proposed as a viable alternative to classically prescribed submaximal endurance training (10,17,20).Today, there are growing social and psychological reasons to encourage RS training within clinical populations. First, RS training is remarkably time efficient and more compatible with the Western world's time-poor modern lifestyle. Second, the concept of RS training may also be more attractive than continuous exercise for sedentary individuals who have difficulty han...

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Clinical evaluation of a portable lactate meter in type I glycogen storage disease

Cited by 42 publications

References 12 publications

The Utility of Early Lactate Testing in Undifferentiated Pediatric Systemic Inflammatory Response Syndrome

The Utility of Early Lactate Testing in Undifferentiated Pediatric Systemic Inflammatory Response Syndrome

Diagnosis and management of glycogen storage disease type I: a practice guideline of the American College of Medical Genetics and Genomics

Parasympathetic reactivation after repeated sprint exercise

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