Clinical Evaluation of a New Multiparameter Neuromonitoring Device: Measurement of Brain Tissue Oxygen, Brain Temperature, and Intracranial Pressure

Abstract

Combining 3 different neuromonitoring functions in 1 probe might ease monitoring by making a second (ptiO2) probe unnecessary. Interpretation of our data is limited by several factors: (1) monocentric study; (2) reduced mechanical probe stability, handling difficulties with the double lumen bolt; (3) design changes to improve mechanical stability will require further study; (4) conflict of interest with Raumedic because of its support for the study. The conclusion drawn from our study is that the new multiparameter probe evaluated does measure ICP, TBr, and ptiO2. But all the initial data given in this paper have to be interpreted cautiously. A new study will be necessary when the mechanical stability of the new probe has been improved.

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

“…A one-on-one direct intraparenchymal comparison between Licox and Neurovent in 33 patients showed no relevant differences between the Licox (19.5±7.1 mmHg) and Neurovent multiparameter probe derived values (21.7±9.5 mmHg) [71]. This was not confirmed in a preliminary report in 11 mixed TBI and SAH patients [261].…”

“…It has also been used in patients with spontaneous intraparenchymal hemorrhage [69][70][71][72][73][74][75][76], ischemic stroke in children and adults [36,71,77], severe haemorrhagic stroke [78], and in silent infarcts after subarachnoid hemorrhage [79].…”

“…PbtO2 monitoring technology has also been used in brain tumor surgery [71,73,87,88], and for continued postoperative monitoring in awake patients [89]. It has also been used for Normal Pressure Hydrocephalus management in awake patients [90,91].…”

“…PbtO2 is calculated from the fading properties of the fluorescent dye, so called "luminescense quenching". Its sampling area is around 22mm 2 [71].…”

Brain Tissue Oxygen Monitoring and the Intersection of Brain and Lung: A Comprehensive Review

“…Again, with the Neurovent-PTO, higher P btO 2 values were noted, especially when testing in high P aO 2 situations. 27,40,41 Differences between the probes exist and have been partially attributed to the different sampling sizes of the probes. 40,41 The Licox has a sampling size of 13 mm 2 , whereas the Neurovent-PTO samples 22 mm 2 of the surrounding brain tissue.…”