Clinical evaluation of a new collagen sponge and silicone bilayer "artificial mucuos membrane" for the resection of oral tumors.

Kawabe, Ryoichi; Mizuki, Nobuyuki; Usui, Sadahiko; Saito, Tomokatsu; Miyazaki, Chika; Horimoto, Susumu; Umino, Satoshi; Omura, Susumu; Fujita, Kiyohide

doi:10.5981/jjhnc1974.21.219

Cited by 2 publications

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“…While the collagen sponge is gradually decomposed and absorbed, new collagen is produced by the proliferating fibroblasts and is replaced by a new dermis-like tissue in 2 to 3 weeks [ 17 ]. AD-T has shown excellent clinical outcomes not only in skin defect wounds but also in oral mucosal defects [ 15 , 17 , 19 , 20 , 21 , 22 ]. Furthermore, since the silicon membrane attached to AD-T is processed using a polyester mesh, it can be sutured and fixed to the surrounding tissue [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model

et al. 2022

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In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis ® Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm 2 wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti-cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material.

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