Clinical evaluation for sublingual immunotherapy with Dermatophagoides farinae drops in adult patients with allergic asthma

Zhong, Cheng; Yang, Weidong; Li, Y; Zou, Linglong; Deng, Zhihui; Liu, M; Huang, Xianbo

doi:10.1007/s11845-017-1685-x

Cited by 11 publications

(12 citation statements)

References 32 publications

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“…Dermatophagoides Farinae Drops, a sublingual immunotherapy drug, has been shown to be effective and safe in preschool and school-age patients with house dust mites- (HDMs-) induced AR and adult patients with AA [ 10 , 11 ]. Though the effectiveness of sublingual specific immunotherapy (SLIT) has been reported [ 12 ], there are relatively few data about the efficacy of sublingual Dermatophagoides Farinae Drops in the treatment of multiple and single respiratory allergic diseases in children.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Wang

Luo

et al. 2020

Canadian Respiratory Journal

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Objective. To evaluate the efficiency of sublingual immunotherapy with Dermatophagoides Farinae Drops in children with single and multiple respiratory allergic diseases. Methods. Seventy-one children with allergic respiratory diseases who had been treated with Dermatophagoides Farinae Drops for one year or more were divided into a single allergic group (12 cases) and multiple allergic group (59 cases). The rhinitis score, daytime and night symptom score of asthma, VAS score, drug score, pulmonary function, and FeNO level before and after treatment were evaluated and compared between the two groups. Results. The rhinitis score, night symptom score, VAS score, and drug score in the single allergic group after treatment were significantly lower than those before treatment ( p < 0.05 ), but there was no significant difference in the daytime symptom score before and after treatment ( p > 0.05 ). The rhinitis score, VAS score, and drug score in the multiple allergic group after treatment were significantly lower than those before treatment ( p < 0.05 ), but there was no significant difference in the scores of daytime symptoms and nighttime symptoms before and after treatment ( p > 0.05 ). In both the single allergic group and multiple allergic group, the pulmonary function indexes of the patients were significantly improved after treatment, and the FeNO after treatment was significantly lower than that before treatment ( p < 0.05 ). There was no significant difference in scores, pulmonary function, and FeNO between the two groups ( p > 0.05 ). Conclusion. Sublingual specific immunotherapy is effective in treating multiple and single allergic respiratory diseases in children.

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Section: Introductionmentioning

confidence: 99%

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Wang

Luo

et al. 2020

Canadian Respiratory Journal

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“…More importantly, the HDM-SLIT tablet is the first allergy immunotherapy to be tested prospectively in a well-designed RCT in patients with HDM allergy-related asthma not well controlled by ICS or combination products and to favorably modify patient relevant end points such as time to first moderate or severe asthma exacerbation upon ICS reduction and reduced risk of an exacerbation with deterioration in asthma symptoms [25]. The potential value of HDM-specific AIT to help step down ICS dosage from GINA step-care levels 3 or 4 [112] and a significantly higher asthma control (p < 0.001) and PEF% (p < 0.05) has also been observed in HDM-allergic asthma patients treated with SLIT compared with usual treatment [113]. Consequently, GINA 2017 reports SLIT as a possible add-on option for adults with asthma and AR sensitized to HDM with exacerbations despite low to high doses of inhaled corticosteroids (ICS) provided [73].…”

Section: Does Slit Reduce Asthma Symptoms Asthma Exacerbations or Asthma Medication In Comparison To Placebo Or Symptomatic Treatment?mentioning

confidence: 96%

Recent Advances in Allergen-Specific Immunotherapy as Treatment for Allergic Asthma: A Practical Overview

Tabar

Delgado

González-Mancebo

et al. 2021

Int Arch Allergy Immunol

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The Global Initiative for Asthma Report updated in 2019 stated that potential benefits of allergen immunotherapy (AIT), compared to pharmacological and avoidance options, must be weighed against the risk of adverse effects and the inconvenience and cost of the prolonged course of therapy in asthma. Thus, with the aim of clarifying some aspects with regard to the possible use of AIT in allergic asthma treatment armamentarium, a group of expert allergists from the Spanish Allergy and Clinical Immunology Scientific Society (SEAIC), particularly from the Immunotherapy and Asthma Interest Groups developed a frequently asked questions in clinical practice. This document updates relevant topics on the use of AIT in asthma and could facilitate physician clinical decisions and improve health outcomes for individual patients.

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“…Vor allem wurde die HSM-SLIT mit Tabletten als erste Allergie-Immuntherapie in einer prospektiven, gut aufgebauten RCT bei Patienten mit HSM-allergiebedingtem, durch IKS oder Kombinationspräparate nicht ausreichend kontrolliertem Asthma untersucht und zeigte dort eine günstige Beeinflussung patientenrelevanter Endpunkte wie der Zeit bis zur ersten mittelschweren bis schweren Asthmaexazerbation nach IKS-Reduktion oder dem Risiko einer Exazerbation mit Verschlechterung der Asthmasymptome [25]. Der potenzielle Wert der HSM-spezifischen AIT im Hinblick auf die Herabstufung der IKS-Dosis von GINA-Level 3 oder 4 [112] sowie signifikant bessere Asthmakontrolle ( p < 0,001) und PEF% ( p < 0,05) zeigte sich auch bei Patienten mit HSM-Allergie und Asthma, welche mit SLIT behandelt wurden, im Vergleich zur Standardtherapie [113]. Entsprechend wurde die SLIT als mögliche Zusatzoption für Erwachsene mit Asthma und AR, die gegen HSM sensibilisiert sind und trotz niedriger bis hoher Dosen IKS Exazerbationen bekommen, in die GINA-Leitlinie 2017 aufgenommen [73].…”

Section: Wirksamkeit Der Ait Bei Erwachsenen Patienten Mit Asthmaunclassified

Aktuelle Fortschritte in der allergenspezifischen Immuntherapie bei allergischem Asthma. Ein praxisorientierter Überblick

et al. 2021

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In ihrem 2019 aktualisierten Bericht schreibt die Global Initiative for Asthma, die möglichen Vorteile der Allergen-Immuntherapie (AIT) gegenüber medikamentösen und Karenzmaßnahmen müssten gegen das Nebenwirkungsrisiko sowie den Aufwand und die Kosten dieser langfristigen Form der Asthmatherapie abgewogen werden. Mit dem Ziel, diesbezüglich bei einigen Aspekten des möglichen Einsatzes der AIT als Teil des therapeutischen Arsenals bei allergischem Asthma mehr Klarheit zu schaffen, hat ein allergologisches Expertengremium aus der Mitgliedschaft der spanischen Fachgesellschaft für Allergologie und klinische Immunologie (SEAIC), genauer gesagt aus deren Arbeitsgruppen für Immuntherapie und Asthma, eine Aufstellung häufiger Fragen für die klinische Praxis zusammengetragen. Dieses Dokument soll den aktuellen Stand wichtiger Aspekte der Anwendung der AIT bei Asthma darstellen, Ärztinnen und Ärzten als klinische Entscheidungshilfe dienen und zu besseren Behandlungsergebnissen für die Patienten beitragen.

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Clinical evaluation for sublingual immunotherapy with Dermatophagoides farinae drops in adult patients with allergic asthma

Abstract: SLIT with D. farinae drops plus pharmacotherapy is more effective than routine drug treatment in adult patients with AA.

Cited by 11 publications

References 32 publications

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Recent Advances in Allergen-Specific Immunotherapy as Treatment for Allergic Asthma: A Practical Overview

Aktuelle Fortschritte in der allergenspezifischen Immuntherapie bei allergischem Asthma. Ein praxisorientierter Überblick

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