Clinical Evaluation

Beckman, Joshua A.; Creager, Mark A.

doi:10.1016/b978-0-7216-0284-4.50044-0

Cited by 6 publications

(2 citation statements)

References 86 publications

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“…Oral-motor assessments conducted by physicians or speech-language pathologists can help identify specific oral motor deficits or neuromotor problems as well as current level of chewing function. Basic areas that are assessed in an oral motor evaluation usually include lip and tongue strength and range of motion, swallow function, chewing, and airway protection (Beckman, 2006). There are several pediatric oral-motor assessments from the speech pathology field and, although they vary in the specific aspects of chewing measured, these assessments may provide useful information (Barton et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Teaching the Skill of Chewing From a Behavior Analytic Approach: A Systematic Review

2022

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Relatively few empirical studies of pediatric chewing interventions have been published in the psychology literature. The purpose of this paper was to systematically review chewing interventions within the applied behavior analysis literature. We identified a small, but growing, behavior analytic literature demonstrating the effectiveness of various multicomponent treatment packages to teach and improve chewing skills. Future researchers should consider a range of participant characteristics, including results of oral motor assessments, explore a more extensive definition of chewing to target the complex nature of chewing as well as component skills, and examine the necessary and sufficient components of chewing interventions along with the potential benefits of multidisciplinary interventions.

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Section: Discussionmentioning

confidence: 99%

Teaching the Skill of Chewing From a Behavior Analytic Approach: A Systematic Review

2022

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“…Abdominal aortic aneurysm (AAA) is a cardiovascular disease defined as permanent dilation of the abdominal aorta greater than 50% or 3 cm [1]. Most AAAs develop in the infrarenal region between the renal veins and the aortic bifurcation [2]. The prevalence of AAA is 4-8% in men older than 60 years and 0.5-1.5% in women, with the rupture of AAA being associated with a high mortality rate [3].…”

Section: Introductionmentioning

confidence: 99%

Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

Elster

Ommer-Bläsius

Lang

et al. 2022

Preprint

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Background: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease, and the pathogenesis is still poorly understood. Recent evidence suggests that AAA displays characteristics of an autoimmune disease and it gained increasing prominence that specific antigen-driven T cells in the aortic tissue may contribute to the initial immune response. Single-cell RNA T- and B cell receptor (TCR and BCR) sequencing is a powerful tool to investigate TCR and BCR clonality and thus to further test this hypothesis. However, difficulties such as very limited numbers of isolated cells must be considered during implementation and data analysis making biological interpretation of the data challenging. Here, we perform a representative analysis of scRNA TCR and BCR sequencing data of experimental murine AAA and show a reliable and streamlined bioinformatic processing pipeline highlighting opportunities and limitations of this approach. Methods: We performed single-cell RNA TCR and BCR sequencing of isolated lymphocytes from the infrarenal aortic segment of male C57BL/6J mice 3, 7, 14, and 28 days after AAA induction via elastase perfusion of the aorta. Sham operated mice at day 3 and 28 as well as non-operated mice served as controls. Results: Comparison of complementarity-determining region (CDR3) length distribution of 179 B cells and 796 T cells revealed no differences between AAA and control nor between the disease stages. We found no clonal expansion of B cells in AAA. For T cells, we identified multiple clones in 11 of 16 AAA samples and in 1 of 8 control samples. Comparison of the immune receptor repertoires indicated that only few clones were shared between the individual AAA samples. The most frequently used V-genes in the TCR beta chain in AAA were TRBV3, TRBV19, and TRBV12-2+TRBV13-2. Conclusion: In summary, we found no clonal expansion of TCRs or BCRs in elastase-induced AAA in mice. Our findings imply that a more precise characterization of TCR and BCR distribution requires a more extensive amount of T and B cells to prevent undersampling and to enable detection of potential rare clones. Using this current scSeq-based approach we did not identify clonal enrichment of T or B cells in experimental AAA.

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