Clinical estimation of the efficacy mesenchymal stem cells and bioplastic material Collost for treating gingival recession in the experiment in vivo

Рубникович, С.П.; Denisova, Yu. L.; Andreeva, V. A.; Kvacheva, Z. B.; Panasenkova, G. Yu.; Khomich, I.

doi:10.17116/rosstomat20181102135

Cited by 3 publications

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References 2 publications

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“…At present, investigations are conducted to identify the efficiency of application of cell technologies in various fields of medicine, including periodontology [11][12][13][14][15][16][17]. The scientific sources include evidence on the reduced propagation and intensity of the gingival recession [16,18,19] and on improvement of periodontium microcirculation processes when MSCs are used [17,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

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confidence: 99%

Morphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells

Рубникович¹,

Sirak²,

Денисова³

et al. 2020

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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The article presents the analysis of the morphological changes of the periodontal tissues of laboratory animals using mesenchymal stem cells (MSCs). The goal of the study is to create a model of experimental periodontitis and to identify the characteristics of morphological changes in the periodontal tissues using a biomedical cell product based on the allogeneic adipose tissue of MSCs (AT MSCs). The application of a mixture of AT MSCs and osteoinduced AT MSCs (in the ratio of 1:1) allows reducing the time of bone defect regeneration in comparison to that of bone tissue regeneration when AT MSCs and osteoinduced AT MSCs are used separately, which is expressed in the filling of the bone defect with a fibroreticular osteogenic tissue, as well as with a muscle tissue one month after surgery. In 2 months, in the defect area filled with a collagen membrane with a mixture of AT MSCs and osteoinduced AT MSCs, the initial signs of the formation of trabecula of bones were detected, which is evident of a more comprehensive osteosynthesis process compared to the blood clot use.

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mentioning

confidence: 99%

Morphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells

Рубникович¹,

Sirak²,

Денисова³

et al. 2020

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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“…Таким образом, проведение аргументированных исследований по применению в стоматологии мезенхимальных стволовых клеток, направленных на активацию процессов восстановления в тканях периодонта, позволит повысить эффективность лечения пациентов с рецессией десны [7][8][9][10][11][12][13][14][15].…”

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Clinical reasoning of application of stem cells in the treatment of gingival recession

et al. 2019

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The aim of the study is to improve the results of complex treatment of patients with gingival recession on the basis of validation of new, highly eﬀective methods using autologous mesenchymal stem cells. A complex treatment was conducted in 93 patients with an anatomical recession of the gum in combination with dentoalveolar anomalies at the age of 20 to 29 years. Patients were divided into 3 groups depending on the treatment used. All patients underwent periodontological treatment. In the 2nd group, patients underwent periodontological treatment including orthodontic equipment, in the 3rd group, they underwent orthodontic treatment, and a cell transplant based on a mixture of autologous mesenchymal stem cells and sterile bioplastic collagen material “Collost” was used. A comprehensive assessment of the periodontal tissue of the three groups showed that among the patients who received the standard treatment complex, a good condition of the periodontal tissues in 1 to 2 years after treatment was noted only in 16.7 % of the patients of the 1st group. Inclusion of orthodontic treatment made it possible to obtain good results in 25 % of patients in the 2nd group, which is 8 % more than in the 1st group. At the same time, good treatment results were revealed in 94 % of the 3rd group patients, who underwent periodontological and orthodontic treatment using autologous mesenchymal stem cells, which confirms the need for measures aimed to normalize the position of teeth, dentition and bite with the use of small orthodontic long-acting forces, to improve the microcirculation of periodontal tissues, and to restore the contour of marginal dreams. Inclusion of autologous mesenchymal stem cells in the complex treatment of patients with gingival recession is accompanied by a 1.6-fold decrease in the prevalence and gum recession (1.15 mm), and a 2.6-fold increase in the tissue volume, by the stimulation of periodontal microcirculation processes (the capillary periodontal pressure is increased by a factor of 1.1 time and the intensity of periodontic microcirculation is increased by a factor of 3.1 times), as well as by the normalization of the position of teeth, dentition and occlusion, which allowed one to obtain good long-term results in 94 % of patients.

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Clinical and roentgenological evaluation of the status of periodontal tissues of laboratory animals in the application of mesenchymal stem cells

Рубникович

Sirak²,

Денисова

et al. 2020

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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The article examines the clinical and roentgenological changes in the periodontal tissues of laboratory animals when mesenchymal stem cells (MSC) are used.The aim of the study is to create a model of experimental periodontitis and identify the characteristics of clinical and radiological changes in periodontal tissues when applying a biomedical cell product based on allogeneic mesenchymal adipose stem cells (AT MSCs).During the examination of the clinical and radiological changes in the periodontal tissues ofexperimental animals with formed bone defects filled with AT MSCs, it was found that the mucous membrane regeneration time in the surgical area was comparable in all main groups of animals. Postoperative gum recession was observed in the control group animals. The significant differences between the clinical pictures in groups I–IV during all observation periods after surgery were not revealed. However, the restoration process signs in the post-resection area found during the roentgenological examination in the groups using osteoinduced MSCs, as well as a mixture of MSC cultures and osteo-induced MSCs, were most pronounced, which is confirmed by the bone mineral density.The experimental periodontitis model, which could be used for assessing the bone tissue restoration processes of a labioratory animal, was developed. Thus, the use of collagen membranes with a suspension of allogeneic osteo-induced AT MSCs cultures, as well as membranes with a suspension of a mixture of allogeneic and allogeneic osteo-induced AT MSCs in the ratio of 1:1 allows achieving higher bone tissue recovery rates.

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Clinical estimation of the efficacy mesenchymal stem cells and bioplastic material Collost for treating gingival recession in the experiment in vivo

Cited by 3 publications

References 2 publications

Morphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells

Morphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells

Clinical reasoning of application of stem cells in the treatment of gingival recession

Clinical and roentgenological evaluation of the status of periodontal tissues of laboratory animals in the application of mesenchymal stem cells

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