Clinical Epidemiology and Treatment of Febrile and Afebrile Convulsions With Mild Gastroenteritis: A Multicenter Study

Higuchi, Yasuhiro; Kubo, Toshio; Mitsuhashi, Toshiharu; Nakamura, Naoko; Yokota, Ichiro; Komiyama, Osamu; Kamimaki, Isamu; Yamamoto, Shozo; Uchida, Yasushi; Watanabe, Kyoko; Yamashita, Hironori; Tanaka, Shigeki; Iguchi, Kosei; Ichimi, Ryouji; Miyagawa, Shinichiro; Takayanagi, Tetsuya; Koga, Hiroshi; Shukuya, Akinori; Saito, Akiko; Horibe, Keizo

doi:10.1016/j.pediatrneurol.2016.05.011

Cited by 20 publications

(20 citation statements)

References 38 publications

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“…Rotavirus is the most common agent associated with CwG. The rotavirus antigen was found in the stool of 22.35% of our patients at the time of initial CwG diagnosis, which is similar to rates in previous reports [3,4,15]. Direct CNS viral invasion and viral enterotoxin NSP4-induced disruption of calcium homeostasis have been hypothesized as possibly underlying the genesis of seizures in CwG [12].…”

Section: Discussionsupporting

confidence: 88%

“…Only a minority showed focal discharges, which revealed a probable focal onset of the seizures and is consistent with the characteristics of benign convulsions in infants [10]. Therefore, we believed that the abnormal EEG findings seen with afebrile seizure recurrences were transient and not absolute indicators of subsequent epilepsy as in the initial CwG episodes [4,39].…”

Section: Discussionsupporting

confidence: 74%

“…Until now, although cases have been reported in Europe and America [2,6,8,14,28], more cases have been described in East Asian countries, mainly Japan, South Korea and China [3][4][5]7,15,[29][30][31][32], where CwG episodes occur in approximately 1% of all acute gastroenteritis cases [12]. The racial difference suggests that the genetic characteristics of the host play a role in the development of CwG.…”

Section: Discussionmentioning

confidence: 99%

“…Benign convulsions associated with mild gastroenteritis (CwG) were first described by Morooka et al in 1982 in Japan [1]. Since then, a number of articles involving hundreds of patients have been published [2][3][4][5][6][7][8]. All the previous studies have agreed on a favorable prognosis for CwG.…”

Section: Introductionmentioning

confidence: 99%

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Clinical outcome of recurrent afebrile seizures in children with benign convulsions associated with mild gastroenteritis

Boman

Chen

Hong

et al. 2018

Seizure

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical outcome of recurrent afebrile seizures in children with benign convulsions associated with mild gastroenteritis

Boman

Chen

Hong

et al. 2018

Seizure

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“…In clinical practice, the manifestations of convulsion associated with viral gastroenteritis can include a febrile status because viral gastroenteritis itself is often accompanied by fever. Few studies have reported the relationship between febrile seizure and CwG 10,11) .…”

Section: Introductionmentioning

confidence: 99%

Convulsions with Noroviral Gastroenteritis in Children at a Single Center in Korea

강수연¹,

이현주²,

김신혜³

2018

Child Neurol

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Viral gastroenteritis is a common disease in infants and children. Seizures can be associated with viral gastroenteritis as benign convulsions with mild gastroenteritis (CwG). After the development of the rotavirus vaccination, norovirus has become inreasingly significant in children. We retrospectively analyzed the clinical features in a pediatric population presenting with seizures and confirmed enteral viral infections, especially norovirus infections. Methods: We retrospectively reviewed the medical records of pediatric patients aged <15 years admitted due to convulsions and gastroenteritis to the Department of Pediatrics of Myongji Hospital between July 2014 and June 2016. Results: A total of 46 patients (24 male and 22 female) were included. Norovirus was detected in 21 (45.7%) patients, adenovirus in three (6.5%), rotavirus in two (4.3%), astrovirus in one (2.2%), and none of agents were detected in 19 (41.3%) patients. Patients in the norovirus gastroenteritis (NGE) group had a higher incidence of diarrhea than that among in the non-norovirus gastroenteritis (NNGE) group (61.9% vs 28.0%; P<0.05). Twelve patients experienced status epilepticus, including five (23.8%) in the NGE group and seven (33.0%) in the NNGE group (P=0.837). Seizures were effectively terminated by intravenous benzodiazepines in 8 (66.7%) of 12 patients. Additional long-acting antiepileptic drugs such as fosphenytoin or levetiracetam were required in three (25%) of 12 patients. Conclusion: Patients with CwG with and without noroviurs infection did not differ in terms of clinical features. However, status epilepticus was not uncommon among patients with CwG by definition.

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A trial of lacosamide for benign convulsions with gastroenteritis

Numoto

Kurahashi

Iwayama

et al. 2020

Brain and Development

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Clinical Epidemiology and Treatment of Febrile and Afebrile Convulsions With Mild Gastroenteritis: A Multicenter Study

Cited by 20 publications

References 38 publications

Clinical outcome of recurrent afebrile seizures in children with benign convulsions associated with mild gastroenteritis

Clinical outcome of recurrent afebrile seizures in children with benign convulsions associated with mild gastroenteritis

Convulsions with Noroviral Gastroenteritis in Children at a Single Center in Korea

A trial of lacosamide for benign convulsions with gastroenteritis

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