Clinical epidemiology and molecular analysis of hospitalized children with hand-foot and mouth disease during 2009 in Shanghai

Yu, Hui; Yan, FX

doi:10.1186/1753-6561-5-s6-p46

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“…10 A vesicular enanthem involving the hard and soft palates, tongue, gingiva, and buccal mucosa is present in nearly 100% of patients. 11,12 Typically, HFMD resolves spontaneously within one week without therapeutic intervention. 10 Most epidemics of HFMD have been caused by serotypes CV-A16 and EV-71.…”

Section: Discussionmentioning

confidence: 99%

Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection

Lott

Liu

Landry

et al. 2013

Journal of the American Academy of Dermatology

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Background Hand, foot, and mouth disease (HFMD) is an acute viral illness commonly caused by coxsackievirus A16 (CV-A16) and enterovirus 71 infections. Recently, atypical HFMD has been reported in association with CV-A6, an uncommon enterovirus strain. Objective To describe the clinical features of atypical HFMD associated with CV-A6 infection and its diagnostic laboratory evaluation. Methods Patients presenting to our institution with history and examination suggestive of atypical HFMD from January 2012 to July 2012 were identified. Morphology and distribution of mucocutaneous lesions were recorded. Enterovirus infection was assessed by reverse transcriptase polymerase chain reaction of biologic specimens. Enterovirus type was determined by viral capsid protein 1 gene sequencing. Results Two adults and 3 children with atypical HFMD were identified. Four of 5 patients exhibited widespread cutaneous lesions. In 2 patients with a prior history of atopic dermatitis, accentuation in areas of dermatitis was noted. Associated systemic symptoms prompted 4 of 5 patients to seek emergency care, and both adults were hospitalized for diagnostic evaluation. Infection with CV-A6 was confirmed in all patients. Limitations This study is a case series from a single institution. Conclusion Consideration of the expanded range of cutaneous findings in atypical HFMD caused by CV-A6 infection may assist clinicians in diagnosis and management.

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Section: Discussionmentioning

confidence: 99%