Clinical Epidemiological Study of 553 Patients with Chronic Rhinosinusitis in Japan

Yoshimura, Katsuhiro; Kawata, Ryo; Haruna, Shinichi; Moriyama, Hiroshi; Hirakawa, Katsuhiro; Fujieda, Shigeharu; Masuyama, Keisuke; Takenaka, Hiroshi

doi:10.2332/allergolint.10-oa-0234

Cited by 38 publications

(33 citation statements)

References 22 publications

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“…For example, a recent study showed that 23.1% of patients with CRS in Japan suffered from asthma. 65 Conversely, higher incidence of radiological abnormalities in paranasal sinuses was also seen in asthmatic patients. 66e68 An early study showed that patients with mild-to-moderate asthma had an 88% incidence of abnormal sinus computed tomography (CT) findings, while patients with severe steroiddependent asthma showed 100% abnormal sinus findings on CTscans.…”

Section: Presence and Characterization Of Comorbidity Of Chronic Rhinmentioning

confidence: 91%

Association and management of eosinophilic inflammation in upper and lower airways

Okano

Kariya

Ohta

et al. 2015

Allergology International

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This review discussed the contribution of eosinophilic upper airway inflammation includes allergic rhinitis (AR) and chronic rhinosinusitis (CRS) to the pathophysiology and course of asthma, the representative counterpart in the lower airway. The presence of concomitant AR can affect the severity of asthma in patients who have both diseases; however, it is still debatable whether the presence of asthma affects the severity of AR. Hypersensitivity, obstruction and/or inflammation in the lower airway can be detected in patients with AR without awareness or diagnosis of asthma, and AR is known as a risk factor for the new onset of wheeze and asthma both in children and adults. Allergen immunotherapy, pharmacotherapy and surgery for AR can contribute to asthma control; however, a clear preventive effect on the new onset of asthma has been demonstrated only for immunotherapy. Pathological similarities such as epithelial shedding are also seen between asthma and CRS, especially eosinophilic CRS. Abnormal sinus findings on computed tomography are seen in the majority of asthmatic patients, and asthmatic patients with CRS show a significant impairment in Quality of Life (QOL) and pulmonary function as compared to those without CRS. Conversely, lower airway inflammation and dysfunction are seen in non-asthmatic patients with CRS. Treatments for CRS that include pharmacotherapy such as anti-leukotrienes, surgery, and aspirin desensitization show a beneficial effect on concomitant asthma. Acting as a gatekeeper of the united airways, the control of inflammation in the nose is crucial for improvement of the QOL of patients with co-existing AR/CRS and asthma.

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Section: Presence and Characterization Of Comorbidity Of Chronic Rhinmentioning

confidence: 91%

Association and management of eosinophilic inflammation in upper and lower airways

Okano

Kariya

Ohta

et al. 2015

Allergology International

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“…It is undeniable that this may also reflect a lack of international consensus for defining tissue eosinophilia. While some groups define eosinophilia as an absolute number of eosinophils (five to eight) per random high powered field,3 5 6 others use a cut-off percentage of eosinophils (5–15%) for a number of high power fields counted in areas of greatest cellularity 7 8…”

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confidence: 99%

Role of interleukin 33 in chronic rhinosinusitis

Sehmi

2017

Thorax

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“…К 4 годам окончательно формируются гайморовы пазухи, поэтому увеличивается удельный вес верхнечелюстных синуси-тов. В связи с более поздним формированием фронталь-ных и сфеноидальных синусов их воспаление наблю-дается преимущественно у детей 7-12 лет, нередко встречается комбинированное поражение слизистой оболочки верхнечелюстных пазух и решетчатого лаби-ринта [7,[30][31][32].…”

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“…Для острых риносинуситов более характерна монофло-ра, микробные ассоциации встречаются, по разным дан-ным, в 10-30% всех случаев [19,29,31,32]. Основную роль в возникновении острого воспалительного процесса полости носа и околоносовых пазух в детском возрасте отводят S. pneumoniae (20-35%) и Н. influenzae (6-26%).…”

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The Usage of Topical Antibacterial Drugs in Treatment of Inflammatory Diseases of the Nose, the Nasopharynx and the Paranasal Sinuses in Children

Васильева¹

2012

Vopr. sovr. pediatr.

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Особенности применения топических антибактериальных препаратов в терапии воспалительных заболеваний полости носа, носоглотки и околоносовых пазух у детей The usage of topical antibacterial drugs in treatment of inflammatory diseases of the nose, the nasopharynx and the paranasal sinuses in children

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Clinical Epidemiological Study of 553 Patients with Chronic Rhinosinusitis in Japan

Abstract: Similar to the relationship between nasal allergy and asthma, CRSwNP may be applicable to the concept of "one airway, one disease".

Cited by 38 publications

References 22 publications

Association and management of eosinophilic inflammation in upper and lower airways

Association and management of eosinophilic inflammation in upper and lower airways

Role of interleukin 33 in chronic rhinosinusitis

The Usage of Topical Antibacterial Drugs in Treatment of Inflammatory Diseases of the Nose, the Nasopharynx and the Paranasal Sinuses in Children

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