Clinical–Epidemiological Characteristics of the First Patients Diagnosed with COVID-19 in Cuba

Molina-Águila, Niurka; Cruz-Rodríguez, Elba; Ferrán-Torres, Rita M.; Galindo-Santana, Belkys M.; López-Almaguer, Yanaris; Romero-Placeres, Manuel

doi:10.37757/mr2021.v23.n2.3

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…The observation of an excess of hospitalized cases of COVID-19 among older adults, has been corroborated in other studies. One large retrospective USA analysis revealed a mean age of 61.2 (±17.9) years with younger ages of 41.7 (± 16.3) and 50.6 (range 16-94) years recorded among hospitalized patients in Bangladesh and Cuba (13–15). The disproportionate severity of COVID-19 among older age groups may be due in part to the increased number of comorbidities among the aged, and biological factors such as lower numbers of functional cilia, immunosenescence, inflamm-aging and lower levels of angiotensin converting enzyme 2 (ACE-2) (16,17).…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of COVID-19 at a Teaching Hospital in Kingston, Jamaica

Thompson

Dawkins

Rowe-Gardener

et al. 2022

Preprint

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ObjectiveWe examined the demographic, clinical characteristics and indicators of poor outcomes among hospitalized adults with COVID-19 at the University Hospital of the West Indies, Jamaica.MethodsA retrospective medical record review between March 10 and December 31, 2020 analyzed data for 362 participants.ResultsThere were 218 males (mean age 59.5 years) and 144 females (mean age 55.7 years). Hypertension, diabetes mellitus, cardiovascular disease, obesity and chronic kidney disease were the most common comorbidities. Cough, shortness of breath, fever and malaise were the most common presenting complaints. Fifty-one percent of patients were moderately to severely ill on admission; 11% were critically ill; 18% were admitted to the Intensive Care Unit (ICU). Death occurred in 62 (17%) patients (95% CI 13.6-21.4%). Among obese participants, there were increased odds of developing respiratory failure (OR 5.2, p < 0.001), acute kidney injury (OR 4.7, p < 0.001), sepsis (OR 2.9, p =0.013) and the need for ICU care (OR 3.7, p < 0.001). Factors independently associated with increased odds of death were age (OR 1.03 per year, p = 0.013) and obesity (OR 2.26, p = 0.017). Mortality also correlated significantly with D-dimer > 1000 ng/ml (OR 2.78; p = 0.03), serum albumin < 40 g/L (OR 3.54; p = 0.03) and serum LDH > 485 U/L OR 1.92, p = 0.11).ConclusionsTargeted interventions among these high-risk patient subgroups may reduce in-patient morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of COVID-19 at a Teaching Hospital in Kingston, Jamaica

Thompson

Dawkins

Rowe-Gardener

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Although there are numerous scientific epidemiologic studies of COVID-19 risk factors and disease outcomes in high-income countries, publications from the Caribbean region have been limited. Those available include situation reports (4,14), case series of hospitalized patients (15)(16)(17), surveillance of COVID-19 deaths (18), and oral presentations (19). In Latin America, pre-existing economic and social disparities produced poor outcomes for the most vulnerable persons (20).…”

mentioning

confidence: 99%

Risk factors associated with severe COVID-19 outcomes in Jamaica: a cross-sectional study of national surveillance data

Webster-Kerr,

Grant,

Harris

et al. 2024

Revista Panamericana De Salud Pública

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Objectives. To describe the characteristics and outcomes of COVID-19 cases in Jamaica and to explore the risk factors associated with severe COVID-19 from 9 March to 31 December 2020. Methods. A cross-sectional analysis of national surveillance data was conducted using confirmed COVID-19 cases in Jamaica. Definitions of a confirmed case, disease severity, and death were based on World Health Organization guidelines. Chi-square and Fisher exact tests were used to determine association with outcomes. Logistic regression models were used to determine predictors of severe COVID-19. Results. This analysis included 12 169 cases of COVID-19 (median age, 36 years; 6 744 females [ 55.4%]) of which 512 cases (4.2%) presented with severe disease, and of those, 318 patients (62.1%) died (median age at death, 71.5 years). Severe disease was associated with being male (OR 1.4; 95% CI, 1.2-1.7) and 40 years or older (OR, 6.5; 95% CI, 5.1-8.2). COVID-19 death was also associated with being male (OR, 1.4; 95% CI, 1.1-1.7), age 40 years or older (OR, 17.9; 95% CI, 11.6-27.7), and in the Western versus South East Health Region (OR 1.7; 95% CI, 1.2-2.3). Conclusions. The findings of this cross-sectional analysis indicate that confirmed cases of COVID-19 in Jamaica were more likely to be female and younger individuals, whereas COVID-19 deaths occurred more frequently in males and older individuals. There is increased risk of poor COVID-19 outcomes beginning at age 40, with males disproportionately affected. COVID-19 death also varied by geographic region. This evidence could be useful to other countries with similar settings and to policymakers charged with managing outbreaks and health.

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Clinical–Epidemiological Characteristics of the First Patients Diagnosed with COVID-19 in Cuba

Cited by 2 publications

References 10 publications

Clinical Features and Outcomes of COVID-19 at a Teaching Hospital in Kingston, Jamaica

Clinical Features and Outcomes of COVID-19 at a Teaching Hospital in Kingston, Jamaica

Risk factors associated with severe COVID-19 outcomes in Jamaica: a cross-sectional study of national surveillance data

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