Abstract:The diagnosis for American cutaneous leishmaniasis is based on an association of clinical, epidemiological and laboratory characteristics. The present study identified the circulating species of Leishmania in the State of Pernambuco, described its clinical-epidemiological characteristics and diagnosed the disease. Nineteen patients presenting active lesions who had been diagnosed through clinical evaluation and laboratory tests were selected. The tests included direct investigation, in vitro culturing, Montene… Show more
“…This result was also found in other studies [11][12][13] . However, from 2001 to 2006, the number of reported cases in the City of Governador Valadares was similar for both genders, as 127 cases of ATL were male patients (52.7%) and 114 (47.3%) cases were female patients 14 .…”
Introduction: Governador Valadares is an endemic area of American tegumentary leishmaniasis (ATL). The detection rate was 15.36 per 100,000 habitants from to 2006(Miranda, 2008. This study aimed to analyze the effects of age on the frequency of adverse reactions caused by antimony in the treatment of ATL in the City of Governador Valadares, State of Minas Gerais, Brazil, during 2009. Methods: Data were collected from the forms of the Information System for Notifiable Diseases, and from charts, questionnaires, and home visits to patients. Results: The study included 40 patients, 26 (65%) of whom were males. Individuals over the age of 50 had a 66% higher rate of adverse effects than subjects who were 50 years old or less (CI 95%, 1.14-2.41). The average age of individuals who reported some type of adverse effect was 44.11 years (SD = 20.14), while the average age of the group that did not report any adverse effect was of 25.46 years (SD = 18.37; p < 0.01). Clinical healing was 67.5%, and 10% of patients discontinued the treatment. Conclusions: In the treatment of ATL, the age of patients should be considered, because most adverse reactions occur in individuals over 50 years of age. For this reason, the drug should be used with restriction in these cases.
“…This result was also found in other studies [11][12][13] . However, from 2001 to 2006, the number of reported cases in the City of Governador Valadares was similar for both genders, as 127 cases of ATL were male patients (52.7%) and 114 (47.3%) cases were female patients 14 .…”
Introduction: Governador Valadares is an endemic area of American tegumentary leishmaniasis (ATL). The detection rate was 15.36 per 100,000 habitants from to 2006(Miranda, 2008. This study aimed to analyze the effects of age on the frequency of adverse reactions caused by antimony in the treatment of ATL in the City of Governador Valadares, State of Minas Gerais, Brazil, during 2009. Methods: Data were collected from the forms of the Information System for Notifiable Diseases, and from charts, questionnaires, and home visits to patients. Results: The study included 40 patients, 26 (65%) of whom were males. Individuals over the age of 50 had a 66% higher rate of adverse effects than subjects who were 50 years old or less (CI 95%, 1.14-2.41). The average age of individuals who reported some type of adverse effect was 44.11 years (SD = 20.14), while the average age of the group that did not report any adverse effect was of 25.46 years (SD = 18.37; p < 0.01). Clinical healing was 67.5%, and 10% of patients discontinued the treatment. Conclusions: In the treatment of ATL, the age of patients should be considered, because most adverse reactions occur in individuals over 50 years of age. For this reason, the drug should be used with restriction in these cases.
“…The combination of different molecular approaches allows appropriate parasite identification in areas where sympatric circulation of several Leishmania species is a problem (Bensoussan et al 2006, Tojal da Silva et al 2006. Our study demonstrated a PCR positivity of 89%, which is lower than has been described in other areas (Pirmez et al 1999, Gomes et al 2008, Reis et al 2008). However, our results are consistent with a previous study in the same area that reported a positivity of 88.3% for PCR performed with DNA obtained from fresh-frozen lesion biopsies and positivities of 87% and 85.7% for PCR performed with DNA obtained from biopsy imprints on filter paper in two independent laboratories (Romero et al 2009).…”
“…These rates are higher than those obtained by Silveira et al (7) for cutaneous form ATL (59.4%) and by Curti et al (14) for cutaneous form ATL (65.1%) in the same area. Murback et al (27) observed a rate of 58.8% for positive direct examination in Mato Grosso do Sul State, whereas Reis et al (29) observed a rate of 58% for positive direct examination in Pernambuco State. These variations may be due to several factors such as Leishmania species, parasite load, quality of the material collected, site of the lesion where the parasite is investigated, the number of microscopic fields and slides examined, and experience of the technician (30) .…”
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