Clinical, Epidemiological, and Epizootic Features of Sporothrix brasiliensis in Espírito Santo, Brazil

Rediguieri, Bruno Carneiro; Bahiense, Isabela da Cruz; Carvalho, Jamile Ambrósio de; Leite, Gustavo Rocha; Falqueto, Aloísio; Rodrigues, Alessandro; Gonçalves, Sarah Santos

doi:10.1007/s10393-022-01578-8

Cited by 9 publications

(18 citation statements)

References 47 publications

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“…The diagnosis of sporotrichosis is based on the isolation and identification of Sporothrix in culture, cytopathology, histopathology, sporotrichosis skin test, serology, immunohistochemistry, and molecular techniques [ 10 , 15 , 78 , 116 , 178 ]. Moreover, complementary laboratory tests such as blood count and biochemical profile should be requested in systemic forms.…”

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

“…Conversely, Gram, quick Panoptic, Wright, Giemsa, or Rosenfeld cytopathological staining techniques are more sensitive in animals, particularly felines ( Figure 5 A) [ 116 ]. The cytopathological examination from exudates and skin lesions shows a high fungal burden, making it possible to observe Sporothrix yeast cells that range from being rounded, oval, or cigar-shaped, surrounded by a transparent, capsule-like halo, as seen in Cryptococcus spp.…”

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

“…The quick Panoptic method, a Romanowsky-type staining technique like Diff-Quik, has become relatively common in veterinary clinics due to its practicality, low cost, and great return ( Figure 5 B,C). A staining kit profits around 1000 slides [ 116 , 205 ]. This diagnosis has a sensitivity of 52.6% to 95% in cats compared to culture, the reference method [ 116 , 120 , 206 ].…”

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

“…A staining kit profits around 1000 slides [ 116 , 205 ]. This diagnosis has a sensitivity of 52.6% to 95% in cats compared to culture, the reference method [ 116 , 120 , 206 ]. However, for non-ulcerated or low exudative lesions, treatment with antifungals in high doses seems to interfere negatively with this method’s sensitivity [ 116 , 120 ].…”

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

“…This diagnosis has a sensitivity of 52.6% to 95% in cats compared to culture, the reference method [ 116 , 120 , 206 ]. However, for non-ulcerated or low exudative lesions, treatment with antifungals in high doses seems to interfere negatively with this method’s sensitivity [ 116 , 120 ]. In the last years, the feline sporotrichosis laboratory diagnosis starts with cytology by imprinting the lesions in glass slides and isolating the fungus in culture [ 207 ].…”

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

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Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Rodrigues

Gonçalves

Carvalho

et al. 2022

JoF

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Sporotrichosis, a human and animal disease caused by Sporothrix species, is the most important implantation mycosis worldwide. Sporothrix taxonomy has improved in recent years, allowing important advances in diagnosis, epidemiology, and treatment. Molecular epidemiology reveals that S. brasiliensis remains highly prevalent during the cat-transmitted sporotrichosis outbreaks in South America and that the spread of S. brasiliensis occurs through founder effects. Sporothrix globosa and S. schenckii are cosmopolitan on the move, causing major sapronoses in Asia and the Americas, respectively. In this emerging scenario, one-health approaches are required to develop a creative, effective, and sustainable response to tackle the spread of sporotrichosis. In the 21st century, it has become vital to speciate Sporothrix, and PCR is the main pillar of molecular diagnosis, aiming at the detection of the pathogen DNA from clinical samples through multiplex assays, whose sensitivity reaches remarkably three copies of the target. The treatment of sporotrichosis can be challenging, especially after the emergence of resistance to azoles and polyenes. Alternative drugs arising from discoveries or repositioning have entered the radar of basic research over the last decade and point to several molecules with antifungal potential, especially the hydrazone derivatives with great in vitro and in vivo activities. There are many promising developments for the near future, and in this review, we discuss how these trends can be applied to the Sporothrix-sporotrichosis system to mitigate the advance of an emerging and re-emerging disease.

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Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

Section: Trends In the Diagnosis Of Sporotrichosismentioning

confidence: 99%

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Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Rodrigues

Gonçalves

Carvalho

et al. 2022

JoF

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Sporothrix pathogenic clade: Molecular analysis of animal and human clinical isolates

et al. 2022

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Sporotrichosis is a subcutaneous mycosis that affects animals and humans. Varying in severity, occurrences range from local lesions to systemic involvement. It is caused by thermodimorphic and saprobic fungi from the Sporothrix pathogenic clade. This study aimed to identify the species and the sexual idiomorph distribution patterns responsible for diagnosed cases of sporotrichosis in São José do Rio Preto, Brazil. We included 188 isolates of Sporothrix sp. from feline lesions and 27 of human origin, which underwent molecular identification and genotyping for mating-type MAT1-1 and MAT1-2. The results showed that Sporothrix brasiliensis is the prevalent species in feline sporotrichosis outbreaks with the overwhelming presence of a single mating-type, MAT1-2 (P < 0.0001), suggesting a prevalently clonal form of spread. Morphological analyses did not discriminate among cryptic species in the genus Sporothrix, and molecular identification was essential for the correct identification of the species responsible for the observed cases of sporotrichosis. Distribution analyses of MAT1-2 isolates support the hypothesis of unidirectional migration from the current epidemics in São Paulo and Rio de Janeiro to the municipality of São José do Rio Preto.

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Genotyping and antifungal susceptibility testing of Sporothrix brasiliensis isolates from Southern Brazil

Bombassaro

Spruijtenburg

Medeiros

et al. 2023

Mycoses

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Clinical, Epidemiological, and Epizootic Features of Sporothrix brasiliensis in Espírito Santo, Brazil

Cited by 9 publications

References 47 publications

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Sporothrix pathogenic clade: Molecular analysis of animal and human clinical isolates

Genotyping and antifungal susceptibility testing of Sporothrix brasiliensis isolates from Southern Brazil

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