Clinical Enhancement of Post‐Periodontal Surgical Therapy by a 0.12% Chlorhexidine Gluconate Mouthrinse

Abstract

Previous studies have demonstrated the potential beneficial effects of post-surgical rinsing with 0.2% chlorhexidine. In the present investigation a new chlorhexidine formulation (Peridex) (CHx) and concentration (0.12%) was evaluated clinically to determine if similar effects could be detected from the use of the new product and treatment regimen. A double blind, randomized, placebo-controlled study was carried out in 40 patients during a 6 week period. Patients who had moderate periodontitis (AAP Class III) received osseous periodontal surgery in one quadrant. Each surgical site received periodontal dressing and patients were given a placebo or CHx mouthrinse to be used twice each day. Compared to placebo, CHx significantly reduced plaque at all examinations (54.4% reduction over placebo at 6 weeks, P less than 0.05). Visible plaque (PlI greater than 2) in the CHx group was reduced by 99% over the placebo group at 6 weeks and at 4 weeks post-surgical, gingival inflammation scores were significantly lower in the CHx group (17% reduction over the placebo at 4 weeks, P less than 0.05). Gingival bleeding scores (GI greater than 2) were significantly lower in the CHx group at 4 and 6 weeks (41% and 40% reduction over the placebo group, P less than 0.05). Probing pocket depth and attachment level changes were not significantly different between both groups. Epithelialization rates and pain assessment demonstrated consistently better results in the CHx group, although differences were not statistically significant. Use of 0.12% chlorhexidine immediately following periodontal surgery, for 6 weeks, has been shown to be a clinically effective adjunct providing enhancement of the post-surgical management of periodontal surgical patients.

The Anti-microbial Effect Against Enterococcus faecalis and the Compressive Strength of Two Types of Mineral Trioxide Aggregate Mixed With Sterile Water or 2% Chlorhexidine Liquid

“…Various reports have concluded differing results. Some researchers have reported a cytotoxic effect of CHX on various types of human cells in vitro (16). In contrast, Gabler et al (17) concluded that serum present during the initial healing period seems to provide significant protection against these cytotoxic effects.…”

Comparison of an essential-oil-based oral rinse and chlorhexidine as adjuncts to scaling and root planing in the treatment of periodontal inflammation

“…However, it is pertinent to mention that these oral rinses have not been proven to enhance the healing of gingival tissues after periodontal surgery. In the study by Sanz et al [20]. CHX displayed no statistically significant difference in the healing rate of gingival tissues following periodontal surgery compared with placebo, as measured by epithelialization of the surgical area for up to 1.5 months.…”

Antiplaque and Antigingivitis Toothpastes

“…Several adverse events have been reported with the use of this molecule, including: hypersensitivity reaction after oral use [133], neurosensory deafness when the product is placed in the middle ear [134], taste alterations and presence of a bitter taste [135,136], uni-or bilateral parotid tumefaction [137,138], staining, either of teeth, mucosa, tongue dorsum or restorations [137], mucosal erosion [139], or even alterations in the wound healing process (suggested from in vitro studies). In vivo studies, however, have not found interference with the healing process, but on the contrary, a better resolution of the inflammation was reported [140]. Heating during long periods of time can induce the formation of 4-chloroanilinine, which has been shown to be cancerogenic and mutagenic.…”