Clinical Efficacy Trials With Natural Products and Herbal Medicines

Nance, Christina

doi:10.1002/9781119006039.ch4

Cited by 2 publications

(2 citation statements)

References 106 publications

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“…[10][11][12][13][14][15][16][17][18][19][20][21][22] Proper screening of biologically active natural products results in the identification of various bioactive molecules as well as drugs. [23][24][25][26][27][28][29][30] One such example is the discovery of the first analgesic, anti-inflammatory drug aspirin from the bark of willow tree by Greeks and Romans since 400 BC. In 1989 aspirin (acetylsalicylic acid) was approved as the first drug for the treatment of rheumatic disease.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Mir¹,

Godavari²,

Siddiqui³

et al. 2021

DDDT

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Introduction Oleanolic acid, a pentacyclic triterpenic acid, is widely distributed in medicinal plants and is the most commonly studied triterpene for various biological activities, including anti-allergic, anti-cancer, and anti-inflammatory. Methods The present study was carried out to synthesize arylidene derivatives of oleanolic acid at the C-2 position by Claisen Schmidt condensation to develop more effective anti-inflammatory agents. The derivatives were screened for anti-inflammatory activity by scrutinizing NO production inhibition in RAW 264.7 cells induced by LPS and their cytotoxicity. The potential candidates were further screened for inhibition of LPS-induced interleukin (IL-6) and tumour necrosis factor-alpha (TNF-α) production in RAW 264.7 cells. Results The results of in vitro studies revealed that derivatives 3d, 3e, 3L, and 3o are comparable to that of the oleanolic acid on the inhibition of TNF-α and IL-6 release. However, derivative 3L was identiﬁed as the most potent inhibitor of IL-6 (77.2%) and TNF-α (75.4%) when compared to parent compound, and compounds 3a (77.18%), 3d (71.5%), and 3e (68.8%) showed potent inhibition of NO than oleanolic acid (65.22%) at 10µM. Besides, from docking score and Cyscore analysis analogs (3e, 3L, 3n) showed greater affinity towards TNF-α and IL-1β than dexamethasone. Conclusion Herein, we report a series of 15 new arylidene derivatives of oleanolic acid by Claisen Schmidt condensation reaction. All the compounds synthesized were screened for their anti-inﬂammatory activity against NO, TNF-α and IL-6. From the data, it was evident that most of the compounds exhibited better anti-inﬂammatory activity.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Mir¹,

Godavari²,

Siddiqui³

et al. 2021

DDDT

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“…The well-defined make-up, standardization, and cheap cost make Polyphenon E a very interesting candidate for human clinical studies. Polyphenon E is currently in several trials as a chemopreventive and chemotherapeutic agent against chronic lymphocytic leukemia, bladder and lung cancers (phase II), and in breast cancer (phase I) [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells

Turrini

Calcabrini

Sestili

et al. 2016

Toxins

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Cancer chemotherapy is characterized by an elevated intrinsic toxicity and the development of drug resistance. Thus, there is a compelling need for new intervention strategies with an improved therapeutic profile. Immunogenic cell death (ICD) represents an innovative anticancer strategy where dying cancer cells release damage-associated molecular patterns promoting tumor-specific immune responses. The roots of Withania somnifera (W. somnifera) are used in the Indian traditional medicine for their anti-inflammatory, immunomodulating, neuroprotective, and anticancer activities. The present study is designed to explore the antileukemic activity of the dimethyl sulfoxide extract obtained from the roots of W. somnifera (WE). We studied its cytostatic and cytotoxic activity, its ability to induce ICD, and its genotoxic potential on a human T-lymphoblastoid cell line by using different flow cytometric assays. Our results show that WE has a significant cytotoxic and cytostatic potential, and induces ICD. Its proapoptotic mechanism involves intracellular Ca2+ accumulation and the generation of reactive oxygen species. In our experimental conditions, the extract possesses a genotoxic potential. Since the use of Withania is suggested in different contexts including anti-infertility and osteoarthritis care, its genotoxicity should be carefully considered for an accurate assessment of its risk–benefit profile.

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Clinical Efficacy Trials With Natural Products and Herbal Medicines

Cited by 2 publications

References 106 publications

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells

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