Clinical efficacy of Vyaghriharitaki Avaleha in the management of chronic bronchitis

Ram, Jai Prakash; Baghel, Madhav Singh

doi:10.4103/0974-8520.169009

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…In traditional Indian system of medicine, it is broadly used to treat many respiratory disease conditions. Its extract is used to treat conditions like chronic bronchitis and tuberculosis 2 , 3 . A pilot study, on clinical efficacy of S. trilobatum and Solanum xanthocarpum , confirmed the usefulness of these herbs in bronchial asthma.…”

Section: Introductionmentioning

confidence: 99%

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

Lateef

Prabhudas

Natarajan

2018

Sci Rep

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Solanum trilobatum L. is an important medicinal plant in traditional Indian system of medicine belonging to Solanaceae family. However, non-availability of genomic resources hinders its research at the molecular level. We have analyzed the S. trilobatum leaf transcriptome using high throughput RNA sequencing. The de novo assembly of 136,220,612 reads produced 128,934 non-redundant unigenes with N50 value of 1347 bp. Annotation of unigenes was performed against databases such as NCBI nr database, Gene Ontology, KEGG, Uniprot, Pfam, and plnTFDB. A total of 60,097 unigenes were annotated including 48 Transcription Factor families and 14,490 unigenes were assigned to 138 pathways using KEGG database. The pathway analysis revealed the transcripts involved in the biosynthesis of important secondary metabolites contributing for its medicinal value such as Flavonoids. Further, the transcripts were quantified using RSEM to identify the highly regulated genes for secondary metabolism. Reverse-Transcription PCR was performed to validate the de novo assembled unigenes. The expression profile of selected unigenes from flavonoid biosynthesis pathway was analyzed using qRT-PCR. We have also identified 13,262 Simple Sequence Repeats, which could help in molecular breeding. This is the first report of comprehensive transcriptome analysis in S. trilobatum and this will be an invaluable resource to understand the molecular basis related to the medicinal attributes of S. trilobatum in further studies.

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Section: Introductionmentioning

confidence: 99%

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

Lateef

Prabhudas

Natarajan

2018

Sci Rep

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“…Finally, disease control, attracting heavy rain, effects on animals, pollution control, mental and physical fitness are gray areas where many more experiments and works have to be done. However, very innovative results as per Vedic scriptures could be established and verified (Ram et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Scientific Aspects of the Indian Vedic Sciences and Their Effect on Stress

Rastogi

Chaturvedi

Rajeshwari³

et al. 2022

International Journal of Reliable and Quality E-Healthcare

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Indian Ancient Vedic Science, which has fascinated the world researchers, has become more relevant in the 21st century because of other global crises and threats. It has shown a powerful impact in all the areas of life, especially in curing physical and mental ailments. The various violent incidents in European countries and the USA have forced the world political, religious and science leaders to find alternative remedies. Mental fitness has been a great challenge. Yajna Science has multiple advantages and affirmative responses in this direction. The author's team presents this study that measures Vedic Mantra and Yajna Sciences' effect on stress, anxiety, and checks its impact in a worldwide depression-like scenario. The data analysis and visualizations have been done in python to show the different mental fitness angles, taking various demographic parameters into account.

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“…As per Ayurvedic texts, one of the primary reasons for the occurrence of any kind of Shwasa Roga (respiratory disease) is Srotorodha (obstruction) of the Pranavaha Srotas (microchannel); this Srotorodha is mainly caused by the vitiation of the Kapha and Vata Doshas [17,[19][20][21][22]. The occurrence of breathlessness after exertion is called Shrama Shwasa, which is a predominant symptom of vitiated Pranavaha Srotas; the vitiation of Pranavaha Srotas causes morbidity in the heart leading to Hridrog (heart disease) [17,19,20,23].…”

Section: Discussionmentioning

confidence: 99%

Application of an Integrated Approach including Yagya Therapy for the Management of Acute Pulmonary Edema with Mild Cardiomegaly

Shrivastava¹,

Batham²,

Mishra³

et al. 2020

Preprint

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Background: A case report about a female patient has been presented here, who was suffering from multiple complaints including severe breathlessness, low grade fever, node in the chest, sleeplessness, etc., and whose diagnostic tests indicated acute pulmonary edema and mild cardiomegaly. Ever since the occurrence of low grade fever and breathlessness, the patient had been on allopathic medication. It was considered to be a possible case of Sarcoidosis. Since about four and a half months, the patient had been on a tapering dose of steroids, and these were recommended to be continued for another two months. The persisting symptoms of low grade fever, breathlessness, and other associated ailments had significantly degraded the quality of life of the patient. Methodology: The patient was prescribed an integrated approach including Yagya Therapy (using an appropriate herbal formulation - havan samagri), and some other Ayurvedic treatments like decoction of medicinal herbs, Ayurvedic medicines, dietary recommendations, etc., which had to be taken alongside the already continuing allopathic treatment (which continued for about 2.5 months). Results: According to a feedback collected from the patient about 2 years after starting the integrated approach including Yagya Therapy, the complaints of low grade fever, sleeplessness, body pain, loss of appetite, constipation and weakness were completely resolved; the complaint of breathlessness was almost completely resolved; the node in the chest had disappeared about seven months after starting the integrated approach (including Yagya Therapy); X-ray Chest (done about four months after starting the integrated approach, and also after about two years), and CT scan (CECT Chest and Abdomen) (done about seven months after starting the integrated approach) indicated normal condition. After starting the integrated approach (including Yagya Therapy), within about 2 to 3 months, the patient had started feeling improvement in her condition - now the patient was feeling completely normal, and expressed willingness to continue with the integrated approach (including Yagya Therapy). Conclusion: The integrated approach including Yagya Therapy showed encouraging results with regards to the treatment of the present disease condition.

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Clinical efficacy of Vyaghriharitaki Avaleha in the management of chronic bronchitis

Cited by 4 publications

References 2 publications

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

RNA sequencing and de novo assembly of Solanum trilobatum leaf transcriptome to identify putative transcripts for major metabolic pathways

Scientific Aspects of the Indian Vedic Sciences and Their Effect on Stress

Application of an Integrated Approach including Yagya Therapy for the Management of Acute Pulmonary Edema with Mild Cardiomegaly

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