Clinical efficacy of paiteling in the treatment of condyloma acuminatum infected with different subtypes of HPV

Hu, Yanqing; Lu, Yan; Qi, Xinyu; Chen, Xuyang; Liu, Kangxing; Zhou, Xianyi; Yang, Yonggang; Mao, Zuhao; Wu, Zhiyang; Hu, Yongxuan

doi:10.1111/dth.13065

Cited by 13 publications

(7 citation statements)

References 11 publications

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“…The level of CD8+ in the study group was lower than that in the control group (34.81 ± 2.34%). Related studies have shown that the levels of CD3+, CD4+, and CD8+ in peripheral hematoma of patients with condyloma acuminatum in the anal canal are significantly lower than those without recurrence, indicating that there is a significant correlation between the recurrence rate of patients with condyloma acuminatum in the anal canal and their own immune level [ 27 ]. The determination of the levels of CD3+, CD4+, and CD8+ in patients with CA in the anal canal is of great clinical significance to evaluate the prognosis and observe the curative effect.…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Wang

Hong

2022

Journal of Healthcare Engineering

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A case-control study is performed in this paper to explore various possible effects and clinical value of the photodynamic therapy combined with thymosin for the treatment process of the condyloma acuminatum (CA) in the anal canal. For this purpose, a hundred (100) patients specifically with CA in the anal canal who were regularly treated in the hospital from February 2019 to April 2021 were recruited. The first group, that is, the control group, was treated with thymosin, whereas photodynamic therapy combined with thymosin was used as a treatment for the study group. The curative effect, clinical index, LTN, SP, TGF-β 1, TNF-α, CD3+, CD4+, CD8+, and the adverse reactions of incidence were compared between these groups. Moreover, 27 cases were observed to be obviously effective, 22 were observed to be effective, and a single case was observed to be ineffective. Thus, 98% is the total effective rate where a single case relapses. Likewise, in the control group, 15 cases were observed to be obviously effective, 28 effective, and 13 ineffective. Thus, 86% is the total rate of effectiveness where thirteen (13) cases relapse. We have observed that the study group has a higher rate of effectiveness than the control group and the rate of recurrence of the former group was slightly lower than that of the latter group, that is, the control group ( P < 0.05). In addition, the time of symptom improvement, the amount of bleeding, the disappearance time of bloody stool, and the time of the first recurrence of the study group were observed to be lower than those of the control group ( P < 0.05). In levels of LTN and SP, we have observed no or zero significant differences between these groups before treatment. However, LTN’s levels of both groups increased after the treatment, and SP’s level decreased. LTN’s level of the study group was observed to be higher than that of the other group, and SP’s level in the former group was lower than that in the latter group. Zero significant differences were observed in the TGF-β 1 and TNF-α’s levels between these groups before treatment, but the level of TGF-β 1 and TNF-α has increased and decreased, respectively, in both groups specifically after treatment. The level of TGF-β 1 in the former group was observed to be slightly higher than that in the latter group, that is, the control group, while TNF-α’s level in the study group was lower than that in the control group. We have not observed any significant difference in CD4+, CD3+, and CD8+ levels between these groups before treatment. However, after treatment, CD3+ and CD4+ levels increased, and the levels of CD8+ decreased in both groups, while CD3+ and CD4+ levels in the former group were evident to be higher than those in the latter group and the level of the CD8+ in the study group was observed to be lower than that in the control group. Finally, we compared the adverse reactions of incidence between these groups. There were 4 cases of tingling sensation and 1 case of redness and swelling in the group study along with a total incidence of 10%. There were 5 cases of tingling sensation and 2 cases of redness and swelling in the control group along with a total incidence of 14%. The incidence of adverse reactions in the study group was observed to be slightly lower than that in the control group, but a significant difference was not observed between these groups (χ2 = 0.378; P > 0.05).

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Section: Discussionmentioning

confidence: 99%

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Wang

Hong

2022

Journal of Healthcare Engineering

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“…Screening for other sexually transmitted infections is essential. Due to its rarity, consensus on management and treatment is challenging and many treatment options are mentioned in literature, such as podophyllin, 5-fluorouracil, methotrexate, bleomycin, interferon, oral retinoid therapy and even paiteling 2 9 12–14. Minimally-invasive techniques (cryotherapy, photodynamic therapy, CO2 laser ablation, electrosurgery or curettage) and radiotherapy may also be used in some smaller lesions 2 9 14.…”

Section: Descriptionmentioning

confidence: 99%

Vulvar condyloma of Buschke and Löwenstein: an unusual tumour in developed countries

et al. 2022

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“…Recently, there has been interest in traditional Chinese medicine paiteling in the treatment of CCA and HPV infection; Hu et al described the efficacy of the traditional Chinese medicine paiteling in the treatment of CCA, in 100 patients with a standardized treatment scheme, without controls, and posttreatment follow-up, and a cure of 92% of the sample and recurrence was reported of 8% at 6 months of treatment [ 26 ]. Shu et al to implement it in a 67-year-old man with AGC on the penis who refused penectomy treatment show a total response without showing recurrence at 3 months of follow-up [ 27 ].…”

Section: Clinical Managementmentioning

confidence: 99%

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

Condoy

Acuña-Pinzón

Chavarría-Chavira

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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Giant condyloma acuminatum (GCA) or Buschke-Loewenstein tumor is a rare disease, with an estimated prevalence of 0.1%. It was initially described in 1896 by Buschke and later in 1925 by Buschke and Loewenstein. Classic condyloma acuminata (CCA) and squamous cell carcinoma (SCC) were initially described as different entities. These three entities are currently considered to correspond to the same spectrum of different but not exclusive malignant transformations, associated with multiple risk factors such infection by human papilloma virus (HPV), immunodeficiencies, poor hygiene, multiple sexual partners, and chronic genital infections. HPV subtypes 6 and 11 are associated with 90% of GCA. It presents as a cauliflower-like tumor in the genital region with bad odor, bleeding, and local infection, differential diagnosis with multiple conditions should be considered, and sexually transmitted diseases should always be investigated. GCA has a higher rate of malignant transformation than CCA and tends to infiltrate adjacent soft tissues. The therapeutic approach is controversial but is considered that the resection with free edges is the gold standard and can be combined with adjuncts. The recurrence rate is high. Overall mortality is 21% and is associated with morbidity caused by recurrences. Imiquimod cream 5% has recently shown good results as monotherapy and in combination with ablative and surgical treatments. The quality of life is diminished in patients with this condition. In this review, we address the different aspects of this rare entity including the therapeutic approach.

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Clinical efficacy of paiteling in the treatment of condyloma acuminatum infected with different subtypes of HPV

Cited by 13 publications

References 11 publications

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Vulvar condyloma of Buschke and Löwenstein: an unusual tumour in developed countries

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

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