Clinical efficacy of new α-bisabolol mouthwashes in postoperative complications of maxillofacial surgeries: a randomized, controlled, triple-blind clinical trial

Amora-Silva, Bruno Frota; Ribeiro, Saulo C. M.; Vieira, Catarina; Mendes, Francisco Rogênio da Silva; Vieira‐Neto, Antônio Eufrásio; Abdon, Ana Paula Vasconcellos; Costa, Francisco Hiran Farias; Campos, Adriana Rolim

doi:10.1007/s00784-018-2464-4

Cited by 8 publications

(18 citation statements)

References 36 publications

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“…Bu yüzden, yara iyileşmesinin hızlanmasına yardımcı olan ve hasta konforunu artıran çalışmaların sayısı artmaktadır. Düşük seviyeli lazer tedavisi, lazer fototerapi, ozon uygulaması, α-bisabolol gargaralar, plateletten zengin plazma uygulaması, topikal antosiyanin kompleks uygulaması vs. yara iyileşmesini geliştirmek için son dönemde tercih edilen tedavilerdir [17][18][19][20][21][22] .…”

Section: Discussionunclassified

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

Taşdemir¹,

Köy²,

Oskaybaş³

et al. 2019

EÜ Dişhek Fak Derg

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Section: Discussionunclassified

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

Taşdemir¹,

Köy²,

Oskaybaş³

et al. 2019

EÜ Dişhek Fak Derg

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“…Notably, the efficacy of the oral or topical administration of BISA suggests its clinical importance as a promising adjuvant for orofacial pain treatment. Interestingly, a clinical research already verified that BISA mouthwash contributes to pain relief and healing in postoperative maxillofacial surgeries (Amora-Silva et al, 2019). Similarly, eucalyptol, a natural monoterpenoid used as the main active component of several essential oils, including that extracted from Tasmanian bluegum, has antinociceptive effects via its antagonism to TRPA1 (Melo Júnior et al, 2017).…”

Section: Terpenementioning

confidence: 99%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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“…Clinically, α-Bisabolol containing mouthwash was evaluated on thirty patients undergoing maxillofacial surgery in a randomized controlled trial. The study found similar efficiency of α-Bisabolol based mouthwash to that of chlorhexidine in reducing pain during brushing and the urge of rubbing or wiping sutures and lesions [ 88 ]. Collectively, this data (briefly summarized in Table 6 ) suggests that α-Bisabolol possess an anti-nociceptive effect that may led development of α-Bisabolol as a future analgesic agent to relieve pain of various origins.…”

Section: α-Bisabolol and Antinociceptionmentioning

confidence: 99%

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

et al. 2022

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α-Bisabolol is one of the important monocyclic sesquiterpenes, derived naturally from essential oils of many edible and ornamental plants. It was first obtained from Matricaria chamomilla, commonly known as chamomile or German chamomile. The available literature indicates that this plant along with other α-Bisabolol containing plants is popularly used in traditional medicine for potential health benefits and general wellbeing. Nutritional studies are indicative of the health benefits of α-Bisabolol. Numerous experimental studies demonstrated pharmacological properties of α-Bisabolol including anticancer, antinociceptive, neuroprotective, cardioprotective, and antimicrobial. This review aims to collectively present different pharmacological activities based on both in vitro and in vivo studies. In the present review using synoptic tables and figures, we comprehensively present that α-Bisabolol possesses therapeutic and protective activities, therefore, it can be used for potential health benefits based on pharmacological effects, underlying molecular mechanism, and favorable pharmaceutical properties. Based on the studies mostly performed in cell lines or animal models, it is evident that α-Bisabolol may be a promising nutraceutical and phytomedicine to target aberrant biological mechanisms which result in altered physiological processes and various ailments. Given the polypharmacological effects and pleiotropic properties, along with favorable pharmacokinetics, and dietary availability and safety, α-Bisabolol can be used as a dietary agent, nutraceutical or phytopharmaceutical agent or as an adjuvant with currently available modern medicines. The regulatory approval of this molecule for use as food additives, and in cosmetics and fragrance industry is also supportive of its human usage. Moreover, further studies are necessary to address pharmaceutical, pharmacological, and toxicological aspects before clinical or nutritional usage in humans. The pharmacological effects and biological actions opens up opportunities on the pharmacological basis of its use in future therapeutics.

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Clinical efficacy of new α-bisabolol mouthwashes in postoperative complications of maxillofacial surgeries: a randomized, controlled, triple-blind clinical trial

Abstract: Considering that BISA has analgesic, antimicrobial, and anti-inflammatory properties, it is relevant to evaluate the efficacy of BISA-based mouthwashes in the oral hygiene of patients undergoing oral and maxillofacial surgery, seeking a better postoperative recovery.

Cited by 8 publications

References 36 publications

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

The effects of ozone therapy on wound healing after gingivectomy operations: a controlled clinical study

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

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