Clinical Efficacy of Narrow-Band UVB (311 nm) Combined with Dithranol in Psoriasis

Carrozza, P.; Häusermann, Peter; Nestle, Frank O.; Burg, Günter; Boni, Roberto

doi:10.1159/000018312

Cited by 28 publications

(16 citation statements)

References 13 publications

(6 reference statements)

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“…In the present study, we found that the efficacy of NB‐UVB therapy in psoriasis varies with different types of the disease. The morphologic type of psoriasis had no influence on the reduction of the PASI, as reported in previous studies (7, 9). However, Picot et al reported that the degree of infiltration of the lesions and their location on the lower limbs could be a factor in the therapeutic results (9).…”

Section: Discussionsupporting

confidence: 84%

“…Animal studies suggest the TL‐01 lamp is two to three times more carcinogenic than broad‐band sources (4). Therefore, additional therapies such as retinoids, calcipotriol, and dithranol with NB‐UVB therapy can be used in order to increase the effectiveness over monotherapy and to allow possible reductions in the cumulative dose of UVB, thus diminishing the potential risk of long‐term treatment (2, 7).…”

Section: Discussionmentioning

confidence: 99%

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Narrow-Band Ultraviolet B Phototherapy in Patients with Psoriasis: For Which Types of Psoriasis Is It More Effective?

Gökdemir

Kıvanç‐Altunay

Köşlü

2005

The Journal of Dermatology

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Narrow-band ultraviolet B phototherapy with Philips TL-01 lamps is being used increasingly in the treatment of psoriasis. However, the effectiveness of phototherapy with narrow-band ultraviolet B in different clinical types of psoriasis vulgaris has not yet been evaluated in the literature. In the present study, we aimed to determine the efficacy and safety of narrow-band ultraviolet B therapy for different clinical forms of psoriasis vulgaris in our patient population. In this open study, 53 patients with psoriasis vulgaris, skin types II--IV, were enrolled. The patients were classified as guttate, nummular, plaque, or mixed according to their predominant morphological lesions. Evaluation of therapeutic efficacy was performed by comparing their Psoriasis Area and Severity Index (PASI) scores before and after treatment. The cumulative dose and the number of treatments were also calculated. Side effects were noted during the therapy. With respect to the different types of psoriasis, reductions of the PASI were not significantly different (p>0.05). The mean cumulative dose and total sessions in the plaque-type group were greater than those in the guttate and nummular groups (p<0.01, p<0.05). Complete clearing was observed in all patients in the guttate-type group, but the result was not statistically significant (p=0.064). Side effects were reported in five (11%) patients. During the 12 months follow-up period, there were no statistically significant differences in the relapse of the disease among the psoriasis groups (p=0.317). In conclusion, we found that the efficacy of narrow-band ultraviolet B therapy in patients with psoriasis decreased as the predominant lesion size enlarged. Before considering narrow-band ultraviolet B therapy for psoriasis, assessment of lesion size may be useful. Combination therapies may be more effective than phototherapy alone if the patient has predominantly large plaques.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Narrow-Band Ultraviolet B Phototherapy in Patients with Psoriasis: For Which Types of Psoriasis Is It More Effective?

Gökdemir

Kıvanç‐Altunay

Köşlü

2005

The Journal of Dermatology

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“…[13] Topical therapies, such as calcipotriene, tazarotene and anthralin, combined with NB-UVB will enhance the efficacy of both modalities and decrease the overall exposure to UV radiation. [14–16] The combination of acitretin with NB-UVB (Re-NB-UVB) appears to have synergistic effects and may decrease the time to clearance and the overall exposure to both modalities. [1718] The acute dose-dependent side effects of NB-UVB are erythema, burning, pigmentation and rare transient lesional blistering.…”

Section: Resultsmentioning

confidence: 99%

Comparative therapeutic evaluation of different topicals and narrow band ultraviolet B therapy combined with systemic methotrexate in the treatment of palmoplantar psoriasis

Gupta¹,

Singh²,

Mohan³

2011

Indian J Dermatol

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Background:The incidence of uncomplicated psoriasis is 1–3% in the general population. The involvement of palm and sole is seen in 7–14.5% of cases. There are different topicals and systemic therapies available for treating the case of psoriasis but none is satisfactory for longer duration.Aim:The study involved the comparative therapeutic evaluation of the different topical regimens and narrow band ultraviolet B (NB-UVB) therapy in combination with systemic methotrexate.Materials and Methods:The study was held in out-patient department of Skin, VD and Leprosy of B.R.D. Medical College, Gorakhpur, from July 2007 to December 2008. The group included 98 new cases of palmoplantar psoriasis. These cases were divided into eight groups according to the eight regimens involved in the study. The severity of psoriasis was assessed by the ESIF (erythema, scaling, induration and fissuring) score.Results:The study showed that all the regimens had significant response rates. The combination of NB-UVB with systemic methotrexate had maximum response rate (64.85±4.52%) that was statistically significant (paired “t” at 16d.f. = 33.329, P<0.001) with minimum number of recurrences after stopping the treatment. The combination of halobetasol ointment with systemic methotrexate also had significant response rate (paired “t” at 19d.f. = 13.5183, P<0.001) but had maximum number of cases with recurrence (70%) after stopping the treatment.Conclusion:These results suggest that the combination of every regimen with systemic methotrexate resulted in an early and a good improvement in the quality of life of patients suffering from psoriasis. It also shows that NB-UVB in combination with systemic methotrexate is more efficacious and has minimum recurrence rate and side effects in the treatment of palmoplantar psoriasis.

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“…In order to reduce cumulative UV doses and to enhance clearance of psoriasis lesions, combination therapies with topical as well as systemic agents have been established: nUVB plus dithranol (Ingram): In many studies the efficacy of dithranol combined with UVB (broadband or narrowband) could be shown (7,52,53). As dithranol is difficult to handle, this therapy is mainly reserved for hospital settings.…”

Section: Psoriasismentioning

confidence: 99%

Phototherapy with Narrowband vs Broadband UVB

Berneburg¹,

Röcken²,

Benedix³

2005

Acta Dermato-Venereologica

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Phototherapy with ultraviolet (UV) radiation of wavelengths between 280 and 320 nm (UVB) is a safe and effective treatment for a variety of diseases. In addition to standard broadband UVB (bUVB), narrowband phototherapy with fluorescent bulbs emitting near monochromatic UV around 311 nm (nUVB) has become an important treatment for diseases such as psoriasis, atopic dermatitis and vitiligo. In addition to these indications, the number of diseases for which nUVB phototherapy is reported to be effective is continuously growing. The differential effects of nUVB phototherapy in comparison to other UV wavelengths as well as established and new indications for this treatment modality are reviewed.

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Clinical Efficacy of Narrow-Band UVB (311 nm) Combined with Dithranol in Psoriasis

Cited by 28 publications

References 13 publications

Narrow-Band Ultraviolet B Phototherapy in Patients with Psoriasis: For Which Types of Psoriasis Is It More Effective?

Narrow-Band Ultraviolet B Phototherapy in Patients with Psoriasis: For Which Types of Psoriasis Is It More Effective?

Comparative therapeutic evaluation of different topicals and narrow band ultraviolet B therapy combined with systemic methotrexate in the treatment of palmoplantar psoriasis

Phototherapy with Narrowband vs Broadband UVB

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