Clinical Efficacy of Levothyroxine Sodium plus I 131 in the Treatment of Patients with Thyroidectomy and Its Effect on the Levels of Thyroglobulin and Thyrotropin

Abstract

Objective. This study was to evaluate the clinical efficacy of levothyroxine sodium tablets combined with I 131 in the treatment of patients after thyroidectomy and the effect on thyroglobulin (Tg) and thyroid stimulating hormone (TSH) levels. Methods. 80 patients with differentiated thyroid cancer who required thyroidectomy after surgery between July 2019 and January 2021 were recruited for prospective study, 40 patients in the control group received levothyroxine sodium tablets, and 40 patients in the experimental group received levothyroxine sodium treatment plus I 131 treatment. Treatment effect, serum Tg and TSH levels, and relapse were measured. Results. The removal rate of residual thyroid tissue in the experimental group (87.50%) was significantly higher than that in the control group (57.50%) ( P < 0.05 ). Levothyroxine sodium tablets plus I 131 was associated with a significantly higher efficacy versus levothyroxine sodium tablets ( P < 0.05 ). There were no significant differences in the serum Tg levels between the two groups before treatment ( P > 0.05 ). After treatment, the serum Tg levels in both groups were significantly decreased, and levothyroxine sodium tablets plus I 131 resulted in a significantly lower Tg level versus levothyroxine sodium tablets ( P < 0.05 ). Before treatment, the two groups showed similar TSH levels ( P > 0.05 ). After treatment, patients receiving levothyroxine sodium tablets plus I 131 had a significantly greater increase in the TSH levels versus levothyroxine sodium tablets ( P < 0.05 ). The recurrence rate of the experimental group was lower than that of the control group ( P < 0.05 ). Conclusion. Levothyroxine sodium tablets plus I 131 for post-operative patients with differentiated thyroid cancer enhance the removal rate of residual thyroid tissue, effectively reduce serum Tg level, and increase TSH level, with significant therapeutic effects, low recurrence rates, and a high safety profile.

Laparoscopic Radical Hysterectomy Combined with Neoadjuvant Chemotherapy for Cervical Cancer Patients Effectively Improves Immune Function

“…Traditional open surgery includes large surgical incisions and significant damage to the abdominal wall muscles, blood vessels, and related nerves, resulting in postoperative complications, compromised prognosis, and a high risk of reoperation. Laparoscopic radical cervical cancer surgery is a minimally invasive method that eliminates the stimulation and contamination of the abdominal cavity by airborne microorganisms, resulting in few postoperative problems, excellent safety, and a favorable patient prognosis [ 31 ]. In addition, the absence of significant differences in terms of postoperative conditions of the two groups of patients, including recatheterization, postoperative blood transfusion, and secondary anti-inflammation, may be attributed to the small sample size of the present study [ 32 ].…”

Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors

“… 19 The other seven studies evaluated the efficacy of levothyroxine tablets against combined therapies. Two included studies compared levothyroxine monotherapy with a combination of levothyroxine and iodine-131, 15 , 16 whereas five other studies evaluated levothyroxine monotherapy against LT4/LT3 combination therapy. 26-30 Of the seven studies, two were of China origin, 15 , 16 while the rest were from Australia, 29 Russia, 30 Brazil, 28 America, 26 and Spain.…”

“…Two included studies compared levothyroxine monotherapy with a combination of levothyroxine and iodine-131, 15 , 16 whereas five other studies evaluated levothyroxine monotherapy against LT4/LT3 combination therapy. 26-30 Of the seven studies, two were of China origin, 15 , 16 while the rest were from Australia, 29 Russia, 30 Brazil, 28 America, 26 and Spain. 27 Regarding patient age, most studies included adults between 18 and 78 years old, except for one study that included newborns aged between 3 to 5 days old.…”

“…Regarding the clinical safety and efficacy of levothyroxine sodium tablets in improving levels, two studies investigated the effect of sodium levothyroxine tablet monotherapy compared with the levothyroxine tablet combined iodine (131). 15 , 16 Based on their findings, the treatment regimen of sodium levothyroxine tablets combined with iodine 131 effectively reduced the serum Tg levels implying its effectiveness over levothyroxine tablet monotherapy. Pooled-meta-analysis results showed a statistically significant difference between LT4 tablet monotherapy and the combined regimen of L-T4 and iodine-131 (SMD= 3.61, 95% CI= [2.89, 4.33], p < 0.00001) ( Figure 9 ).…”

Retracted: Clinical Efficacy of Levothyroxine Sodium plus I 131 in the Treatment of Patients with Thyroidectomy and Its Effect on the Levels of Thyroglobulin and Thyrotropin

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”