Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot study

Grusovin, Maria Gabriella; Bossini, S.; Calza, Stefano; Cappa, Veronica; Garzetti, G. G.; Scotti, Eleonora; Gherlone, Enrico; Mensi, Magda

doi:10.1007/s00784-019-03065-x

Cited by 34 publications

(31 citation statements)

References 31 publications

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“…The impact of probiotics administration in the management of periodontitis has also been evaluated in a wider spectrum of different patients, like systemically inconspicious non-smokers (64,65,67,68,70), smokers (54,71), smokeless tobacco users (74), periodontal recall patients (73,78) or individuals with intellectual disabilities (79). They were also affected by diverging periodontal conditions like previously untreated periodontitis of varying severity, periodontitis aftercare (73,78) or residual deep periodontal pockets (75).…”

Section: Probiotics In the Management Of Periodontitis Evaluated Study Cohortsmentioning

confidence: 99%

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Probiotics in the Management of Gingivitis and Periodontitis. A Review

Schlagenhauf

Jockel‐Schneider

2021

Front. Dent. Med

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In the management of intestinal health problems, the targeted use of probiotic microorganisms is a common therapeutic measure with a long-standing tradition. In clinical dentistry however, probiotics-based therapy is still a rather new and developing field, whose usefulness for the control of gingivitis and periodontitis has been questioned by recent meta-analyses and systematic reviews. The purpose of the subsequent descriptive review is to provide an introduction to the concept of probiotic microorganisms and their multifaceted health-promoting interactions with the human host and microbial competitors, followed by a detailed comparison of the results of available controlled clinical trials assessing the use of probiotics in the control of gingival and periodontal inflammations. It aims at contributing to a deeper understanding of the unique capabilities of probiotics to resolve chronic plaque-induced inflammation even in the absence of mechanical plaque control and will discuss how possible misconceptions about the rationale for using probiotics may have led to the present controversies about their usefulness as a therapeutic option.

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Section: Probiotics In the Management Of Periodontitis Evaluated Study Cohortsmentioning

confidence: 99%

“…In 14 out of 20 RCTs assessed in this review the reduction of pocket depth was the primary study outcome (66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)82), followed by the gain of clinical attachment (64,80,81) and the reduction of markers of inflammation, like gingival bleeding or bleeding on probing (54,65,79).…”

Section: Evaluated Study Outcomesmentioning

confidence: 99%

Probiotics in the Management of Gingivitis and Periodontitis. A Review

Schlagenhauf

Jockel‐Schneider

2021

Front. Dent. Med

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“…Grusovin et al [8] evaluated for 12 months the effects of a Lactibacillus reuteri DSM 17938 and PTA 5389 probiotic combination in patients treated for a stage III-IV periodontitis, grade C. In the probiotic group, there was a higher reduction of mean PD throughout the study, higher clinical attachment level (CAL) gain at 6 months, and higher reduction of BOP at 6 and 9 months.…”

Section: Probiotics In Periodontitismentioning

confidence: 99%

“…Probiotics can outcompete pathogenic bacteria and increase the proportion of beneficial bacteria in the mouth thereby contributing for the prevention and therapy of oral diseases [4][5][6]. In order to be effective in the oral cavity, probiotics must support oral environmental conditions, adhere to and colonize oral surfaces, inhibit oral pathogens [7,8], and/or delay colonization by pathogenic strains [5]. Furthermore, they must not ferment the sugars in order to avoid the pH decrease and demineralization of the enamel, they should hamper the organization of the extracellular matrix responsible for biofilm formation, limit the production of cytotoxic products by pathogenic bacteria, and beneficially alter the biochemical parameters that influence the dental plaque (e.g., salivary components, buffer capacity) (Figure 1) [9].…”

Section: Introductionmentioning

confidence: 99%

Probiotics in Oral Health and Disease: A Systematic Review

Saïz¹,

Taveira²,

Alves³

2021

Applied Sciences

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Purpose: Probiotics may exclude or antagonize oral pathogens and be useful to prevent oral dysbiosis and treat oral diseases. The objective of this review was to assess the benefits of probiotics in oral health and disease, and in dental practice; Methods: Primary articles published between January 2012 and 30 December 2020 with full text available were searched in PubMed, ClinicalTrials.gov, ScienceDirect, Google Scholar, B-on, and SciELO; Results: The electronic search identified 361 references of which 91 (25.2%) met all the inclusion criteria. In total, data from 5374 participants with gingivitis, periodontitis, peri-implantitis, caries, orthodontic conditions, halitosis, or oral conditions associated with chemo-radiotherapy were included. Despite major inconsistencies between clinical trials, probiotics have been found to contribute to reduce S. mutans counts (L. paracasei SD1), reduce probing depth in chronic periodontitis (B. animalis subsp. lactis DN-173010 with L. reuteri), reduce levels of volatile sulfur compounds and halitosis (L. salivarius WB21), treat oral mucositis and improve the quality of life of patients undergoing cancer chemo-radiotherapy (L. brevis CD2). Combinations of probiotic bacteria tend to lead to higher clinical efficacy than any individual probiotic agent; Conclusion: Oral probiotics influence favorably the oral microbiota and provide benefits to the oral ecosystem in periodontal diseases, cariology, halitosis, orthodontics and management of oral mucositis resulting from cancer treatment. However, the use of probiotics in dental practice or in self-management preventive strategies requires additional well controlled clinical trials to determine the most effective probiotic combinations, the most appropriate probiotic vehicle, and the frequency of administration.

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“…Recently, some mechanisms of the beneficial effects of L. reuteri in promoting health and preventing infections and diverse diseases have been proposed: (1) producing antimicrobial molecules, such as organic acids, ethanol, and reuterin to inhibit the colonization of pathogenic microbes and reconstruction of the commensal microbiota composition in the host; (2) enhancing the immune system by promoting regulatory T cell development and function; and (3) enhancing mucosal barrier function [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Administration of Lactobacillus reuteri Combined with Clostridium butyricum Attenuates Cisplatin-Induced Renal Damage by Gut Microbiota Reconstitution, Increasing Butyric Acid Production, and Suppressing Renal Inflammation

et al. 2021

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Cisplatin-induced nephrotoxicity is associated with gut microbiota disturbance. The present study aimed to investigate whether supplementation of Lactobacillus reuteri and Clostridium butyricum (LCs) had a protective effect on cisplatin-induced nephrotoxicity through reconstruction of gut microbiota. Wistar rats were given different treatments: control, cisplatin (Cis), cisplatin + C. butyricum and L. reuteri (Cis+LCs), and C. butyricum and L. reuteri (LCs). We observed that cisplatin-treated rats supplemented with LCs exhibited significantly decreased renal inflammation (KIM-1, F4/80, and MPO), oxidative stress, fibrosis (collagen IV, fibronectin, and a-SMA), apoptosis, concentration of blood endotoxin and indoxyl sulfate, and increased fecal butyric acid production compared with those without supplementation. In addition, LCs improved the cisplatin-induced microbiome dysbiosis by maintaining a healthy gut microbiota structure and diversity; depleting Escherichia-Shigella and the Enterobacteriaceae family; and enriching probiotic Bifidobacterium, Ruminococcaceae, Ruminiclostridium_9, and Oscillibacter. Moreover, the LCs intervention alleviated the cisplatin-induced intestinal epithelial barrier impairment. This study indicated LCs probiotic serves as a mediator of the gut–kidney axis in cisplatin-induced nephrotoxicity to restore the intestinal microbiota composition, thereby suppressing uremic toxin production and enhancing butyrate production. Furthermore, the renoprotective effect of LCs is partially mediated by increasing the anti-inflammatory effects and maintaining the integrity of the intestinal barrier.

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Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot study

Cited by 34 publications

References 31 publications

Probiotics in the Management of Gingivitis and Periodontitis. A Review

Probiotics in the Management of Gingivitis and Periodontitis. A Review

Probiotics in Oral Health and Disease: A Systematic Review

Administration of Lactobacillus reuteri Combined with Clostridium butyricum Attenuates Cisplatin-Induced Renal Damage by Gut Microbiota Reconstitution, Increasing Butyric Acid Production, and Suppressing Renal Inflammation

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