Clinical efficacy of IV prostaglandin E₁and IV pentoxifylline in patients with arterial occlusive disease of fontaine stage IIb: A multicenter, randomized comparative study

PGE1 and Other Prostaglandins in the Treatment of Intermittent Claudication: A Meta-analysis

“…Three-month follow-up data were available for 3 PGE 1 trials [6][7][8] but for none of the other prostaglandins. In general, follow-up results were in agreement with those achieved by the end of treatment.…”

“…2 Prostaglandins are well established in the pharmacologic treatment of critical limb ischemia (PAD stage III/IV according to Fontaine), but they, especially prostaglandin E 1 (PGE 1 ), have also shown clinical benefit in reducing the symptoms of intermittent claudication. [3][4][5][6][7][8][9][10][11][12][13][14][15] However, the therapeutic benefit of different prostaglandins in intermittent claudication in relation to each other has until now not been well defined. Since most studies were performed with PGE 1 , the aim of the present meta-analysis, in contrast to that published by Reiter et al, 16 was to focus on the efficacy and tolerability of PGE 1 in comparison to other prostaglandins and placebo.…”