Clinical efficacy of hyaluronic acid in the treatment of periodontal intrabony defect: a systematic review and meta-analysis

Ostos-Aguilar, Bertha Inés; Furquim, Camila Pinheiro; Muniz, Francisco Wilker Mustafa Gomes; Faveri, Marcelo; Meza‐Mauricio, Jonathan

doi:10.1007/s00784-022-04855-6

Cited by 6 publications

(6 citation statements)

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“…Recent advances in comprehending the interplay between inflammatory pathways and osteogenic mechanisms in periodontitis have prompted researchers to investigate the potential of extracellular matrix components related to inflammation in facilitating periodontal tissue regeneration. 53 Hence, the Shed-Cu-HA hydrogel was proposed in the present study. It exhibits favorable injectability and fluidity, enabling it to reach deep and narrow periodontal pockets with minimal invasiveness.…”

Section: ■ Results and Discussionmentioning

confidence: 94%

“…To avoid the risks of traditional periodontal surgery, researchers are exploring novel biomaterials that possess both anti-inflammatory and antibacterial properties, while also promoting periodontal bone regeneration. Recent advances in comprehending the interplay between inflammatory pathways and osteogenic mechanisms in periodontitis have prompted researchers to investigate the potential of extracellular matrix components related to inflammation in facilitating periodontal tissue regeneration . Hence, the Shed-Cu-HA hydrogel was proposed in the present study.…”

Section: Results and Discussionmentioning

confidence: 99%

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Synergistic Effects of Shed-Derived Exosomes, Cu²⁺, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

Yu,

Li,

Ying

et al. 2024

ACS Appl. Mater. Interfaces

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The primary pathology of periodontitis involves the gradual deterioration of periodontal tissues resulting from the inflammatory reaction triggered by bacterial infection. In this study, a novel drug for periodontal pocket injection, known as the Shed-Cu-HA hydrogel, was developed by incorporating copper ions (Cu 2+ ) and Shed-derived exosomes (Shed-exo) inside the hyaluronic acid (HA) hydrogel. Suitable concentrations of Cu 2+ and Shed-exo released from Shed-Cu-HA enhanced cell viability and cell proliferation of human periodontal ligament stem cells. Additionally, the Shed-Cu-HA demonstrated remarkable antibacterial effects against the key periodontal pathogen (Aa) owing to the synergistic effect of Cu 2+ and HA. Furthermore, the material effectively suppressed macrophage inflammatory response via the IL-6/JAK2/STAT3 pathway. Moreover, the Shed-Cu-HA, combining the inflammation-regulating properties of HA with the synergistic osteogenic activity of Shed-exo and Cu 2+ , effectively upregulated the expression of genes and proteins associated with osteogenic differentiation. The experimental findings from a mouse periodontitis model demonstrated that the administration of Shed-Cu-HA effectively reduced the extent of inflammatory cell infiltration and bacterial infections in gingival tissues and facilitated the regeneration of periodontal bone tissues and collagen after 2 and 4 weeks of injection. Consequently, it holds significant prospects for future applications in periodontitis treatment.

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Section: ■ Results and Discussionmentioning

confidence: 94%

Section: Results and Discussionmentioning

confidence: 99%

Synergistic Effects of Shed-Derived Exosomes, Cu²⁺, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

Yu,

Li,

Ying

et al. 2024

ACS Appl. Mater. Interfaces

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“…[ 216 ] Scientific evidence supports the topical application of these gels for treating gingivitis, and for non‐surgical and surgical periodontitis treatment. [ 207 , 210 , 217 , 218 , 219 ]…”

Section: Review Of Regenerative Products In Periodontal Regenerationmentioning

confidence: 99%

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

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Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach is employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra‐bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

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“…A most recent systematic review and meta-analysis concluded that HA + open flap debridement in the treatment of periodontal intrabony defects was significantly better compared with open flap debridement alone in CAL and PD outcomes at 6 months and that HA in combination with bone substitutes did not show significant differences. 58 …”

Section: Biological Effectsmentioning

confidence: 99%

“… 74 , 75 But the variety of varied methodologies, heterogeneous data, and conclusions makes it challenging to establish HA as a convincing regenerative material. Based on the highest level of evidence 58 in this review, HA is valuable in the treatment of periodontal bone defects. However, further research is essential to endorse HA as a bone regenerative material in different periodontal and oral implant-related settings.…”

Section: Biological Effectsmentioning

confidence: 99%

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

Mansour,

Acharya,

Alliot

et al. 2024

Journal of Oral Biology and Craniofacial Research

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Clinical efficacy of hyaluronic acid in the treatment of periodontal intrabony defect: a systematic review and meta-analysis

Cited by 6 publications

References 50 publications

Synergistic Effects of Shed-Derived Exosomes, Cu²⁺, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

Synergistic Effects of Shed-Derived Exosomes, Cu²⁺, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

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Clinical efficacy of hyaluronic acid in the treatment of periodontal intrabony defect: a systematic review and meta-analysis

Cited by 6 publications

References 50 publications

Synergistic Effects of Shed-Derived Exosomes, Cu2+, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

Synergistic Effects of Shed-Derived Exosomes, Cu2+, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Hyaluronic acid in Dentoalveolar regeneration: Biological rationale and clinical applications

Contact Info

Product

Resources

About

Synergistic Effects of Shed-Derived Exosomes, Cu²⁺, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration

Synergistic Effects of Shed-Derived Exosomes, Cu²⁺, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration