Clinical efficacy of heparin-bonded bypass circuits related to cytokine responses in children

Ozawa, Tsukasa; Yoshihara, Kazuhiro; Koyama, Nobuya; Watanabe, Yoshinori; Shiono, Noritsugu; Takanashi, Yoshinori

doi:10.1016/s0003-4975(99)01336-3

Cited by 46 publications

(20 citation statements)

References 27 publications

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“…It is thus unclear whether steroids provide an additional benefit when aprotinin and MUF are used in combination. Finally, our survey reveals the relatively limited use of heparin-coated circuits, despite a small study that suggested clinical benefit in infants (26). Additional variables that may have an important impact on the inflammatory response to CPB were not addressed in this study.…”

Section: Discussionmentioning

confidence: 92%

Steroid use before pediatric cardiac operations using cardiopulmonary bypass: An international survey of 36 centers*

Checchia

Bronicki

Costello

et al. 2005

Pediatric Critical Care Medicine

123

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Although nearly all centers surveyed administer steroids before cardiopulmonary bypass, the type, dosing, route, and timing of administration are highly variable. The inconsistencies in these data and the pediatric literature would support the undertaking of a large, multiple-center clinical trial to evaluate the risks and benefits of steroid administration before pediatric cardiopulmonary bypass.

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Section: Discussionmentioning

confidence: 92%

Steroid use before pediatric cardiac operations using cardiopulmonary bypass: An international survey of 36 centers*

Checchia

Bronicki

Costello

et al. 2005

Pediatric Critical Care Medicine

123

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“…Reports on the TNF‐α response after CPB are conflicting. A significant increase in TNF‐α was demonstrated after release of the aortic cross clamp and termination of CPB in some studies (23–25), while others report no detectable TNF‐α (26, 28). In a few studies, TNF‐α was detectable preoperatively (18, 28–30) but without further changes in TNF‐α plasma concentration during or after CPB (18, 29, 30).…”

Section: Cytokinesmentioning

confidence: 99%

The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children

Christensen¹

2001

Acta Anaesthesiol Scand

141

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Paediatric cardiac surgery often requires cardiopulmonary bypass (CPB) during the surgical intervention. CPB is known to elicit a systemic inflammatory response with activation of the complement and coagulation systems, stimulation of cytokine production, cellular entrapment in organs, neutrophil activation with degranulation, platelet activation, and endothelial dysfunction. These changes are associated with a risk of postoperative organ dysfunction and increased morbidity and mortality in the postoperative period. Clinical studies have concentrated on measurement of inflammatory markers and mediators in peripheral blood, where the systemic inflammatory response in the paediatric cardiac patient seems to be different from the adult case. Looking at the organ level, experimental studies have the advantage of providing information contributing to a better understanding of the pathological events that may lead to the deteriorated organ function. This review focuses on the systemic inflammatory response after cardiac surgery with CPB in children and experimental CPB models.

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“…A total of 12 studies met our inclusion criteria for this meta‐analysis . These 12 included studies were composed of 190 CHD patients treated with CPB surgery.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 12 studies met our inclusion criteria for this metaanalysis. 21,24,[32][33][34][35][36][37][38][39][40][41] These 12 included studies were composed of 190 CHD patients treated with CPB surgery. The heterogeneity was significantly observed (T1 vs T2: I 2 =92.4%, P h <.001; T2 vs T3:…”

Section: Associations Between the Changes Of Tnfα Serum Levels Andmentioning

confidence: 99%

Serum TNF‐α levels in children with congenital heart disease undergoing cardiopulmonary bypass: A cohort study in China and a meta‐analysis of the published literature

Song

Chuanming

Zhou

2016

Clinical Laboratory Analysis

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Clinical efficacy of heparin-bonded bypass circuits related to cytokine responses in children

Cited by 46 publications

References 27 publications

Steroid use before pediatric cardiac operations using cardiopulmonary bypass: An international survey of 36 centers*

Steroid use before pediatric cardiac operations using cardiopulmonary bypass: An international survey of 36 centers*

The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children

Serum TNF‐α levels in children with congenital heart disease undergoing cardiopulmonary bypass: A cohort study in China and a meta‐analysis of the published literature

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