Clinical Efficacy of Conservative Treatment with Micronized Purified Flavonoid Fraction in Female Patients with Pelvic Congestion Syndrome

Akhmetzyanov, R. V.; Бредихин, Р. А.

doi:10.1007/s40122-021-00312-6

Cited by 12 publications

(3 citation statements)

References 16 publications

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“…Additionally, 1000 mg of MPFF once daily has demonstrated benefits for treating PVI, significantly improving the clinical severity scores and quality of life and reducing thrombosis rates. 18 , 19 We observed favorable clinical outcomes with the implemented medical and surgical treatment.…”

Section: Discussionmentioning

confidence: 72%

Painful ejaculation in a patient with pelvic venous insufficiency

Cifuentes

Ulloa²,

Uden³

et al. 2022

Journal of Vascular Surgery Cases, Innovations and Techniques

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Section: Discussionmentioning

confidence: 72%

Painful ejaculation in a patient with pelvic venous insufficiency

Cifuentes

Ulloa²,

Uden³

et al. 2022

Journal of Vascular Surgery Cases, Innovations and Techniques

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“…The commonly used drugs are spooning, e.g. , horse chestnut seed extract, the micronized purified flavonoid fraction (MPFF), and flavonoids[ 12 - 14 ]. Pentoxifylline is reported to target inflammatory cytokine release, leukocyte activation, and platelet aggregation at the microcirculatory level.…”

Section: Medical Therapymentioning

confidence: 99%

Strategies and challenges in treatment of varicose veins and venous insufficiency

Gao¹,

Qian²,

Wang³

et al. 2022

WJCC

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Patients with varicose veins can be treated with conservative or surgical approaches based on the clinical conditions and patient preferences. In the recent decade, the recommendations for managing symptomatic varicose veins have changed dramatically due to the rise of minimally invasive endovascular techniques. The literature was systematically searched on Medline without language restrictions. All papers on the treatment of varicose veins and venous insufficiency with different procedures were included and reviewed. Endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) both are same safe and effective in terms of occlusion rate, and time to return to normal activity. In comparison with RFA or EVLT, Cure conservatrice et Hemodynamique de l'Insufficience Veineuse en Ambulatoire (CHIVA) may cause more bruising and make little or no difference to rates of limb infection, superficial vein thrombosis, nerve injury, or hematoma. In terms of recurrence of varicose veins, there is little or no difference between CHIVA and stripping, RFA, or EVLT. Great saphenous vein recanalization is highest in the ultrasound-guided foam sclerotherapy (FS) group (51%) during 1 year of follow-up. The 2013 National Institute for Health and Care Excellence clinical guidelines recommend surgery as a third-line therapeutic option after EVLA or RFA and sclerotherapy. Although the mechanochemical endovenous ablation (MOCA) is a non-thermal, non-tumescent option and appears to be of similar efficacy to stab avulsion with no potential risk of nerve damage, the overall success rate of MOCA is lower than those of other procedures such as EVLA, RFA, or high ligation and stripping. EVLA is the most cost-effective therapeutic option, with RFA being a close second for the treatment of patients with varicose veins. Endovenous thermal ablation (EVLA or RFA) is recommended as a first-line treatment for varicose veins and has substituted the high ligation of saphenofemoral junctional reflux and stripping of varicose veins. Ultrasound-guided FS is associated with a high recurrence rate and can be used in conjunction with other procedures. MOCA and cyanoacrylate embolization appear promising, but evidence of their effectiveness is required.

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“…The pathophysiology of PCS pain includes an array of visceral, somatic and neurological pain generators [ 6 ]. In chronic lower extremity venous insufficiency, the pain state is related to abnormal vessel function [ 7 ]; about four decades ago, Kaupilla et al demonstrated a higher rate of histological vascular anomalies (such as fibrosis, muscular hypertrophy and widened ovarian diameter) in a group of PCS patients affected by CPP [ 8 ]. However, more recent views of pain states emphasize both peripheral and central contributors to nociception.…”

Section: Introductionmentioning

confidence: 99%

Chronic Pelvic Pain in Congestion Pelvic Syndrome: Clinical Impact and Electromyography Pelvic Floor Activity Prior to and after Endovascular Treatment

Corvino,

Giurazza,

Coppola

et al. 2024

JPM

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Background: This study aims to characterize the clinical impact of endovascular treatment in Chronic Pelvic Pain (CPP) patients due to Pelvic Congestion Syndrome (PCS) and to assess the diagnostic value of surface electromyography (sEMG) studies of pelvic floor musculature (PFM) in PCS patients pre- and post-endovascular treatment. Between January 2019 and July 2023, we studied consecutive patients who were referred for interventional radiology assessment and treatment to a tertiary trauma care hospital, had evidence of non-obstructive PCS from Magnetic Resonance Imaging (MRI), had sEMG of PFM and who had undergone endovascular treatment. The primary outcome was clinical, defined as a change in symptom severity after endovascular treatment. The secondary outcome was a difference in the sEMG values pre- and post-endovascular therapy. Results: We included 32 women (mean age 38 years). CPP was the leading symptom in 100% patients, followed by dysmenorrhea (75%) and post-coital pain (68.7%). Endovascular therapy included ovarian vein embolization in 28 patients (87.5%) and internal iliac vein embolization in only 2 patients (6.2%). After a median of 8 (range 6–10) months from endovascular treatment, 29 (90%) of patients reported an improvement of the main symptoms, and 15 (46%) were symptom-free. The sEMG values did not show a statistical difference pre- and post-PCS endovascular treatment. Conclusions: Endovascular treatment appeared to be highly effective in CPP due to PCS and was associated with a low rate of complication. sEMG study could be useful in revealing alterations of PFM electrophysiology, but a difference pre- and post-embolization in PCS patients was not demonstrated.

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Clinical Efficacy of Conservative Treatment with Micronized Purified Flavonoid Fraction in Female Patients with Pelvic Congestion Syndrome

Cited by 12 publications

References 16 publications

Painful ejaculation in a patient with pelvic venous insufficiency

Painful ejaculation in a patient with pelvic venous insufficiency

Strategies and challenges in treatment of varicose veins and venous insufficiency

Chronic Pelvic Pain in Congestion Pelvic Syndrome: Clinical Impact and Electromyography Pelvic Floor Activity Prior to and after Endovascular Treatment

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