Clinical Efficacy of Bone Marrow Aspirate Concentrate Versus Stromal Vascular Fraction Injection in Patients With Knee Osteoarthritis: Letter to the Editor

Baria, Michael R.; McGee, Cally; Vasileff, W Kelton; Durgam, Sushmitha

doi:10.1177/03635465211055456

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…These results are similar to those in the study by Wang S et al, 22 and they suggest that the treatment of KOA with glucosamine hydrochloride combined with compound osteopeptide injection improves the treatment efficacy, reducing the inflammation. The study of Baria MR et al 23 showed that when glucosamine hydrochloride combined with compound osteopeptide injection is used to treat patients with KOA, it can effectively reduce the expression level of inflammatory factors, inhibiting inflammation and oxygen free radical damage, reducing the expression level of MMPs, inhibiting the cartilage damage, improving the immune function, and increasing the levels of CD4 + and CD8 + , a finding consistent with ours. In addition, we also found few adverse drug reactions and no serious adverse events during the treatment (without significant differences between the study groups) indicating that the treatment scheme of glucosamine hydrochloride combined with compound osteopeptide injection is relatively safe.…”

Section: Discussionsupporting

confidence: 89%

Clinical effect of glucosamine hydrochloride combined with compound osteopeptide injection for knee osteoarthritis

Liu,

He,

Liu

2023

Pak J Med Sci

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Objective: To investigate the clinical efficacy of glucosamine hydrochloride combined with compound osteopeptide injection for knee osteoarthritis (KOA). Methods: We retrospectively collected clinical data of 82 patients with KOA admitted to Shandong Weifang People’s Hospital from April 2019 to September 2022. According to the treatment records, 35 patients received an intramuscular injection of compound osteopeptide (control group), and 47 patients received an injection of glucosamine hydrochloride combined with compound osteopeptide (observation group). We compared clinical efficacy, WOMAC scores, inflammatory factor and CD4+ and CD8+ levels, and the incidence of adverse reactions between the two groups. Results: The observation group’s total efficacy (95.74%) was significantly higher than the control group’s (80.00%; P<0.05). Treatment led to a significant reduction in WOMAC scores in both groups. In addition, the levels of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the observation group were significantly lower than those in the control group (P<0.05); while the levels of CD4+ and CD8+ were significantly higher in the observation group (P<0.05). Conclusions: Compared with compound osteopeptide injection alone, glucosamine hydrochloride combined with compound osteopeptide injection is more effective for patients with KOA, with improved level of inflammatory factors and immune function. doi: https://doi.org/10.12669/pjms.39.6.8151 How to cite this: Liu MH, He K, Liu F. Clinical effect of glucosamine hydrochloride combined with compound osteopeptide injection for knee osteoarthritis. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.8151 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 89%