Clinical Efficacy of Apple Polyphenol for Treating Cedar Pollinosis

Kishi, Kazumasa; Saito, Masahiro; Saito, Takao; Kumemura, Megumi; Okamatsu, Hiroshi; Okita, Misa; Takazawa, Kenji

doi:10.1271/bbb.69.829

Cited by 30 publications

(26 citation statements)

References 11 publications

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“…Also, using of the fruits and vegetables containing polyphenols reduce damages of allergic disorders. Kishi et al (2005) reported that a red perilla extract (luteolin being the main ingredient) and rubus suavissinmus extract (ellagitannin being the main ingredient) alleviated the symptoms of cedar pollinosis through antiallergic action (Kishi et al, 2005). Apple major polyphenol (Ap) is condensed tannin (ACT) and it is also contains such monomeric polyphenols as catechin, epicatechin, phlorizin, and chlorogenic acid.…”

Section: Resultsmentioning

confidence: 99%

“…It has been reported from a clinical study that Ap alleviated the itching in atopic dermatitis patients. This phenomenon was attributed to the suppression of histamine release by ACT, the major component of apple (Kishi et al, 2005). Through analysis of the clinical evaluation of one kind of traditional remedy in patients with atopic dermatitis, flavonoids were shown to possess significant anti-allergic activity.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Effects of Air Pollution on Cellular Material Release, Allergenicity and Allergens Proteins of Three Ornamental Plants

Rezanejad¹,

Majd²

2011

Advanced Topics in Environmental Health and Air Pollution Case Studies

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Effects of Air Pollution on Cellular Material Release, Allergenicity and Allergens Proteins of Three Ornamental Plants

Rezanejad¹,

Majd²

2011

Advanced Topics in Environmental Health and Air Pollution Case Studies

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“…During the recent few years, other antiallergic dietary substances have been shown to alleviate symptoms of pollinosis [41,42,43]. In these studies, the clinical trials started 2–4 weeks prior to the onset of Japanese cedar pollen release, so that they were designed to determine their preventative effect.…”

Section: Discussionmentioning

confidence: 99%

Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled Trial

Kawai

Hirano

Arimitsu

et al. 2009

Int Arch Allergy Immunol

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Background: Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. Methods: In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two capsules daily of 100 mg EMIQ or a placebo for 8 weeks during the pollen season. Subjective symptoms and activities of daily living (ADL) scores were recorded every day, and the quality of life (QOL) score was obtained every 4 weeks. Blood sampling was performed before and after the study to measure serum cytokines, chemokines, IgE, quercetin and oxidized biomarkers. Results: During the entire study period, total ocular score and ocular itching score for the EMIQ group were significantly lower (p < 0.05) than for the placebo group. When limited to the individual periods, total symptom score for the EMIQ group was significantly lower (p < 0.05, week 4–5) than that for the placebo group while other scores for the EMIQ group, such as total nasal score (p = 0.06, week 4–5), nasal obstruction score (p = 0.08, week 4–5), lacrimation score (p = 0.06, week 5–6), ocular congestion score (p = 0.08, week 4–7) and ADL score (p = 0.08, week 4–7), all tended to be lower. The levels of serum cytokines such as interleukin (IL)-4, IL-5, IL-12, IL-13, interferon-γ, and eotaxin and IgE were not significantly downregulated by the intake of EMIQ but the serum concentrations of oxidized low-density lipoprotein and thymus and activation-regulated chemokine were reduced. Conclusion: Intake of the quercetin glycoside EMIQ was safe and influenced ocular symptoms caused by pollinosis.

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“…12,13 Polyphenols which are abundant in apple are proven effective for allergic rhinitis treatment by preventing degranulation of granulocytes in mast cells. 14,15,16 Procyanidins are polymeric form of catechins. In apple, almost 50% to 60% polyphenols are oligomers and polymers of catechins.Dimeric catechins are procyanidin B1, B2, C1 present in apple extract shows antiallergic activity on rhinitis treatment.…”

Section: Introductionmentioning

confidence: 99%

Immunoinformatics Study of Procyanidins as Mast Cell Stabilizers

Basu¹,

Sarkar

Basak

2018

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Background:Allergens are foreign proteins that stimulate the production of immunoglobulin E (IgE), when they come in contact with human body. These allergens after binding with IgE through FcεRI receptor, triggers the signal transduction reaction in mast cell and basophil cells, leading to allergic reactions by releasing some mediators. Mast cell stabilizer block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine 8 and related mediators e.g. leukotrienes (for basophils) and prostaglandin D2 and IL-5 (for mast cells) during hypersensitivity reaction. Though innumerable synthetic mast cell stabilizers are present 9 in our medicinal science, but the search for suitable natural product as mast cell stabilizer is still going on. 10 Comparative study shows that higher efficiency for natural product quercetin than synthetic compound cromolyn for inhibiting allergic reactions.11 Several inhibitors of IgE:FcεRI binding have been identified e.g. an anti-IgE therapeutic antibody (omalizumab) , an engineered protein inhibitor, DARPin E2_799-11, which are used to treat severe allergic asthma. 12,13 Polyphenols which are abundant in apple are proven effective for allergic rhinitis treatment by preventing degranulation of granulocytes in mast cells. 14,15,16 Procyanidins are polymeric form of catechins. In apple, almost 50% to 60% polyphenols are oligomers and polymers of catechins.Dimeric catechins are procyanidin B1, B2, C1 present in apple extract shows antiallergic activity on rhinitis treatment. Among them, procyanidin C1 extracted from unripe apples (Rosaceae mal- 815 lus) shows anti-allergic effect by various mechanisms e.g. FcεRI induced degranulation and cytokine production of mast cells. Procyanidin C1 which is related with intra-cellular signalling pathway,prevents FcεRI-mediated mast cell activation. 17 The flow cytometric study is confirmed that polymeric procyanidins supress the binding of IgE antibody to FcεRI.17 But the molecular mechanism for inhibitory effect on antibody IgE with FcεRI binding is unknown to all. A compound must have an anti-allergic activity if it inhibits the binding between Ig E antibody and FcεRI receptor during type I hypersensitivity reaction. Comparative studies on different procyanidins structures and physicochemical properties using computational methods will help us to identify apple extract, as herbal medicine in allergic reactions. Computational docking studies are used to elaborate the mechanism of action of various natural products e.g. quercetin glycosides as inhibitor of angiotensinconverting enzyme for the treatment of myocardial infarction 18 and fatty acids of black cumin oil as inhibitors of P-glycoprotein to improve pharmaceutics of many lifesaving drugs. 19 MATERIALS AND METHODS X-ray crystallographic structures for human IgE, FcεRIreceptorThe three-dimensional structure of IgE (PDBID 4J4P) and FcεRI receptor (PDBID 1F2Q) are downloaded from the RCSB protein Data Bank. 20 2D and 3D structures of procyanidin B1, B2, C1 an...

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Clinical Efficacy of Apple Polyphenol for Treating Cedar Pollinosis

Cited by 30 publications

References 11 publications

The Effects of Air Pollution on Cellular Material Release, Allergenicity and Allergens Proteins of Three Ornamental Plants

The Effects of Air Pollution on Cellular Material Release, Allergenicity and Allergens Proteins of Three Ornamental Plants

Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled Trial

Immunoinformatics Study of Procyanidins as Mast Cell Stabilizers

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